What To Do About the Aging of the Glymphatic System?

It is becoming increasingly clear that issues in the drainage of cerebrospinal fluid from the brain play an important role in the onset of neurodegenerative conditions in late life. Neurodegenerative conditions are associated with a build up of various forms of molecular waste, such as toxic misfolded and otherwise altered proteins, in and around brain cells. It is likely that other stress signaling that provokes chronic inflammation in brain tissue is effectively amplified in effect as the drainage channels that normally carry metabolic products from the brain are reduced in capacity with age. Leucadia Therapeutics has focused on the drainage path for the olfactory bulb, through the cribriform plate, in the development of Alzheimer's disease, which begins in this area of the brain specifically. The rest of the research community, meanwhile, is largely interested in the glymphatic system (including meningeal lymphatic vessels) in the context of cerebrospinal fluid drainage. Like the broader lymphatic system, the glymphatic system that drains the brain suffers a range of issues with age that reduce its capacity. Unlike the cribriform plate, there really isn't an obvious starting point for the development of ways to restore this drainage capacity. It seems likely that this is needed, however, and if achieved would significantly slow the degenerative aging of the brain. Overview of the meningeal lymphatic vessels in aging and central nervous system disorders ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs