Lyfspn Working on Clinical Trials of Plasmapheresis

Parabiosis studies involve connecting the circulatory systems of two genetically identical mice, resulting in modest rejuvenation in the older mouse of the pair. The path from those animal studies to age-modifying therapies in humans has been one of twists and turns. At first, the research community focused on potentially beneficial factors in young blood. Elevian's work on GDF11 is still ongoing as an outcome of that research. Over the same period of time, plasma transfusions from young to old humans have produced a lack of convincing data. Later experiments strongly suggested that the real benefit was dilution of harmful factors in old blood, and it remains to be seen as to where that leaves Elevian. Of late, further evidence has arisen to point to the quality of albumin in blood as an important factor, with the hypothesis that dilution works because it usually involves delivery of albumin along with saline or plasma, and thus reduces the amount of harmfully modified albumin already in circulation, rather than for any other reason. Dilution is fairly easy to carry out, and physicians are already doing this for self-experimenters. It still needs a reasonably sized human trial, however, to confirm the beneficial results observed in animal studies. Lfyspn is a new company set up to run exactly this sort of clinical trial, to establish plasma dilution, or albumin replacement, or both, as simple means to improve late life health. Their view is that this is an appro...
Source: Fight Aging! - Category: Research Authors: Tags: Longevity Industry Source Type: blogs