Incidence and clinical progression of asymptomatic peripherally inserted central catheter < em > - < /em > related thrombosis in solid neoplasm patients: ultrasound insights from a prospective cohort study
CONCLUSION: The majority of CRT present asymptomatically within the first 30 days of venous catheter insertion in patients with solid neoplasms. Ultrasound follow-up is valuable for detecting asymptomatic CRT. The risk of CRT was lower with PICC-PORT than with PICC. Additionally, the risk of CRT was found to be higher in patients with high-risk thromboembolic neoplasms. It is crucial for larger studies to confirm the utility of treating asymptomatic thromboses and isolated superficial thrombosis.PMID:38660454 | PMC:PMC11039392 | DOI:10.1016/j.rpth.2024.102391 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 25, 2024 Category: Hematology Authors: Mattia Cominacini Sergio De Marchi Federica Tosi Elia Piccinno Alessandro Dal Corso Elisa Dalla Grana Francesca Stefani Luca Dalle Carbonare Source Type: research
Tachyphylaxis and reproducibility of desmopressin response in perioperative persons with nonsevere hemophilia A: implications for clinical practice
CONCLUSION: Tachyphylaxis in the surgical setting was considerably more pronounced than previously reported, with FVIII:C at D1 and D2 of 36% to 43% of the initial response. Our results may have important implications for monitoring repeated desmopressin treatment when used perioperatively.PMID:38660455 | PMC:PMC11039391 | DOI:10.1016/j.rpth.2024.102367 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 25, 2024 Category: Hematology Authors: L G R Romano L M Sch ütte R M van Hest K Meijer B A P Laros-van Gorkom L Nieuwenhuizen J Eikenboom F C J I Heubel-Moenen N Uitslager M Coppens K Fijnvandraat M H E Driessens S Polinder M H Cnossen F W G Leebeek R A A Math ôt M J H A Kruip DAVID and SYMP Source Type: research
Cancer and arterial thrombosis: therapeutic options
Res Pract Thromb Haemost. 2024 Mar 27;8(3):102393. doi: 10.1016/j.rpth.2024.102393. eCollection 2024 Mar.ABSTRACTA State of the Art lecture titled "Cancer and Arterial Thrombosis: Therapeutic Options" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. This State of the Art review delves into the complex relationship between cancer and arterial thromboembolism (ATE), encompassing acute coronary syndrome, ischemic strokes, and peripheral arterial disease. The burden of cancer-associated ATE is not well defined, but studies indicate elevated risks, particularly in the 6 months after a c...
Source: Thrombosis and Haemostasis - April 25, 2024 Category: Hematology Authors: May Anne Cheong Avi Leader Source Type: research
Exploring the Two-Way Link Between Migraines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
CONCLUSION: The findings of this Mendelian Randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population.PMID:38657649 | DOI:10.1055/a-2313-0311 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 24, 2024 Category: Hematology Authors: Yang Wang Xiaofang Hu Xiaoqing Wang Lili Li Peng Lou Zhaoxuan Liu Source Type: research
A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura
CONCLUSION: The USTMA Mortality Index was acceptable for predicting mortality due to acute iTTP in the USTMA registry, but not sensitive enough to rule out death. Identifying patients at high risk of iTTP-related mortality may help individualize care and ultimately improve iTTP survival outcomes. Further studies are needed to provide external validation. Our model is one of many recent examples where machine learning models may show promise in clinical prediction tools in healthcare.PMID:38651093 | PMC:PMC11033197 | DOI:10.1016/j.rpth.2024.102388 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Chong Zhang Angela P Presson Shruti Chaturvedi Ana G Antun Andrew M Farland Ryan Woods Ara Metjian Yara A Park Gustaaf de Ridder Briana Gibson Raj S Kasthuri Darla K Liles Frank Akwaa Todd Clover Lisa Baumann Kreuziger Meera Sri Source Type: research
Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation
CONCLUSION: Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.PMID:38653482 | DOI:10.1055/a-2311-0117 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Pengyu Zhang Saskia von Ungern-Sternberg Luisa Hastenplug Fiorella Solari Albert Sickmann Marijke Kuijpers Johan Wm Heemskerk Ulrich Walter Kerstin Jurk Source Type: research
A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura
CONCLUSION: The USTMA Mortality Index was acceptable for predicting mortality due to acute iTTP in the USTMA registry, but not sensitive enough to rule out death. Identifying patients at high risk of iTTP-related mortality may help individualize care and ultimately improve iTTP survival outcomes. Further studies are needed to provide external validation. Our model is one of many recent examples where machine learning models may show promise in clinical prediction tools in healthcare.PMID:38651093 | PMC:PMC11033197 | DOI:10.1016/j.rpth.2024.102388 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Chong Zhang Angela P Presson Shruti Chaturvedi Ana G Antun Andrew M Farland Ryan Woods Ara Metjian Yara A Park Gustaaf de Ridder Briana Gibson Raj S Kasthuri Darla K Liles Frank Akwaa Todd Clover Lisa Baumann Kreuziger Meera Sri Source Type: research
Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation
CONCLUSION: Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.PMID:38653482 | DOI:10.1055/a-2311-0117 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Pengyu Zhang Saskia von Ungern-Sternberg Luisa Hastenplug Fiorella Solari Albert Sickmann Marijke Kuijpers Johan Wm Heemskerk Ulrich Walter Kerstin Jurk Source Type: research
A Deep Learning Approach to Predict Bleeding Risk Over Time in Patients on Extended Anticoagulation Therapy
CONCLUSION: Time series follow-up data can improve major bleeding prediction in patients on extended anticoagulation therapy.PMID:38642704 | DOI:10.1016/j.jtha.2024.04.005 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Soroush Shahryari Fard Theodore J Perkins Philip S Wells Source Type: research
Management of Abnormal Uterine Bleeding on Anticoagulation: The Patient-Clinician Perspective
J Thromb Haemost. 2024 Apr 18:S1538-7836(24)00216-2. doi: 10.1016/j.jtha.2024.04.002. Online ahead of print.ABSTRACTBleeding is a well-recognized side effect of anticoagulant therapy, which is used to treat venous thromboembolism (VTE) in individuals of all ages, including those of female sex, who commonly experience VTE as a complication of hormonal therapies and/or pregnancy. Heavy menstrual bleeding (HMB) is also extremely common in reproductive aged individuals of female sex. Despite these overlapping situations, relatively little attention has been paid to the impact of anticoagulant-associated HMB on treatment strate...
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Bethany T Samuelson Bannow Source Type: research
Evaluation, analysis, and reporting of medication adherence for clinical trials of anticoagulants in children: Guidance from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
J Thromb Haemost. 2024 Apr 18:S1538-7836(24)00217-4. doi: 10.1016/j.jtha.2024.04.003. Online ahead of print.ABSTRACTIn response to growing recognition that non-adherence prevents children, adolescents, and young adults from achieving the therapeutic benefits of anticoagulant medication, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis convened a working party on medication adherence. The primary aim of this manuscript was to synthesize recommendations from the larger adherence science literature to provide guidance regarding the classification, collection, and interpretation of anticoagulation ...
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Meghan E McGrady Vera Ignjatovic Sophie Jones Aisha Bruce Neil A Goldenberg Mattia Rizzi Courtney D Thornburg Kevin E Todd Lori Luchtman-Jones Source Type: research
Next Generation Sequencing strategies in venous thromboembolism: in whom and for what purpose ?
J Thromb Haemost. 2024 Apr 17:S1538-7836(24)00218-6. doi: 10.1016/j.jtha.2024.04.004. Online ahead of print.ABSTRACTThis invited review follows the oral presentation "To Sequence or Not to Sequence, That Is Not the Question; But "When, Who, Which and What For?" Is " given during the State Of the Art session Translational Genomics in Thrombosis: From OMICs to Clinics" of the ISTH 2023 congress. Emphasizing the power of next-generation sequencing technologies and the diverse strategies associated with DNA variant analysis, this review highlights the unresolved questions and challenges in their implementation both for the cli...
Source: Thrombosis and Haemostasis - April 19, 2024 Category: Hematology Authors: David-Alexandre Tr égouët Morange Pierre-Emmanuel Source Type: research
Pharmacokinetics of Edoxaban 15 mg in Very Elderly Patients with Nonvalvular Atrial Fibrillation: A Subanalysis of the ELDERCARE-AF Study
CONCLUSION: PK data support edoxaban 15 mg once daily for very elderly NVAF patients with high bleeding risk, with caution for patients with SRI and/or low body weight.PMID:38641335 | DOI:10.1055/s-0044-1785511 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 19, 2024 Category: Hematology Authors: Takeshi Yamashita Yoshiyuki Igawa Masayuki Fukuzawa Takuya Hayashi Stefanie Hennig Ken Okumura Source Type: research
The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Conclusion Our bidirectional two-sample MR analysis did not find genetic evidence supporting a significant association between OSA and VTE in either direction.PMID:38631385 | DOI:10.1055/a-2308-2290 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 17, 2024 Category: Hematology Authors: Zhihai Huang Zhenzhen Zheng Lingpin Pang Kaili Fu Junfen Cheng Ming Zhong Lingyue Song Dingyu Guo Qiaoyun Chen Yanxi Li Yongting Lv Riken Chen Xishi Sun Source Type: research
The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Conclusion Our bidirectional two-sample MR analysis did not find genetic evidence supporting a significant association between OSA and VTE in either direction.PMID:38631385 | DOI:10.1055/a-2308-2290 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 17, 2024 Category: Hematology Authors: Zhihai Huang Zhenzhen Zheng Lingpin Pang Kaili Fu Junfen Cheng Ming Zhong Lingyue Song Dingyu Guo Qiaoyun Chen Yanxi Li Yongting Lv Riken Chen Xishi Sun Source Type: research
