Multicenter evaluation of the haemostatic activity of emicizumab in patients with severe haemophilia A
CONCLUSION: Using a modified TGA, this study showed that patients who experienced breakthrough bleeds while on emicizumab had a lower thrombin generating capacity compared to others with good clinical response to emicizumab.PMID:38583717 | DOI:10.1016/j.jtha.2024.03.022 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2024 Category: Hematology Authors: Laurie Josset Alexandre Leuci Maissaa Janbain Ana ëlle De-Wreede Stephanie Desage Anne Lienhart Val érie Bin Doroth ée Lambert Xavier Delavenne Yesim Dargaud Source Type: research
Multicenter evaluation of the haemostatic activity of emicizumab in patients with severe haemophilia A
CONCLUSION: Using a modified TGA, this study showed that patients who experienced breakthrough bleeds while on emicizumab had a lower thrombin generating capacity compared to others with good clinical response to emicizumab.PMID:38583717 | DOI:10.1016/j.jtha.2024.03.022 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 7, 2024 Category: Hematology Authors: Laurie Josset Alexandre Leuci Maissaa Janbain Ana ëlle De-Wreede Stephanie Desage Anne Lienhart Val érie Bin Doroth ée Lambert Xavier Delavenne Yesim Dargaud Source Type: research
Unmet needs and barriers in venous thromboembolism education and awareness among people living with cancer: A global survey
CONCLUSIONS: This study involving a large and diverse population of individuals living with cancer identifies important unmet needs in VTE-related education, awareness, and support across healthcare systems globally. These findings unveil multilevel opportunities to expedite patient-centered care in cancer-associated VTE prevention and management.PMID:38582384 | DOI:10.1016/j.jtha.2024.03.019 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 6, 2024 Category: Hematology Authors: Nicola Potere Isabelle Mah é Pantep Angchaisuksiri Gabriela Cesarman-Maus Chee Wee Tan Anila Rashid Farjah H AlGahtani Egidio Imbalzano Nick van Es Avi Leader Edeghonghon Olayemi Ettore Porreca Fionnuala N í Áinle Helen C Okoye Matteo Candeloro Didier Source Type: research
The effect of administering preprocedural VITamin K on the international normalized ratio in patients anticoagulated with ACEnocoumarol (VITKACE-study)
CONCLUSIONS: Using oral vitamin K while patients continue acenocoumarol intake is an effective way to adequately lower INR before an invasive procedure. Low amount of bleeding complications and absence of thromboembolic complications suggest that this is a safe strategy. The INR-values returned gradually to therapeutic range after the procedure, probably contributing to the observed low bleeding rate.PMID:38580096 | DOI:10.1016/j.jtha.2024.03.016 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 5, 2024 Category: Hematology Authors: Stella Bijkerk Harm J Lourens Wout G N Mares Corine A van Kampen Maurits J van der Veen Henk J Adriaansen Erik D Ponfoort Barbara Festen G Wouter Westendorp J örgen M P Rovers Gerie M C Groot Hans-Peter R Bootsma Linde M Amelung Sander Bins Gerjo Velders Source Type: research
The effect of administering preprocedural VITamin K on the international normalized ratio in patients anticoagulated with ACEnocoumarol (VITKACE-study)
CONCLUSIONS: Using oral vitamin K while patients continue acenocoumarol intake is an effective way to adequately lower INR before an invasive procedure. Low amount of bleeding complications and absence of thromboembolic complications suggest that this is a safe strategy. The INR-values returned gradually to therapeutic range after the procedure, probably contributing to the observed low bleeding rate.PMID:38580096 | DOI:10.1016/j.jtha.2024.03.016 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 5, 2024 Category: Hematology Authors: Stella Bijkerk Harm J Lourens Wout G N Mares Corine A van Kampen Maurits J van der Veen Henk J Adriaansen Erik D Ponfoort Barbara Festen G Wouter Westendorp J örgen M P Rovers Gerie M C Groot Hans-Peter R Bootsma Linde M Amelung Sander Bins Gerjo Velders Source Type: research
Noninterventional study assessing joint health in persons with hemophilia A after switching to turoctocog alfa pegol: design of pathfinderReal
CONCLUSION: The pathfinderReal study will provide insights regarding the impact of N8-GP on joint health in persons with hemophilia A in a real-world setting.PMID:38572481 | PMC:PMC10987329 | DOI:10.1016/j.rpth.2024.102363 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Cihan Ay Olga Benitez-Hidalgo Gillian Gidley Maria Elisa Mancuso Davide Matino Azusa Nagao Laszlo Nemes John Waller Johannes Oldenburg Source Type: research
Machine learning-based predictive models for patients with venous thromboembolism: A Systematic Review
CONCLUSION: ML-CPMs show promise in improving risk assessment and individualized treatment recommendations in VTE. Apparently, there is an urgent need for standardized reporting and methodology for ML models, external validation, prospective and real-world data studies, as well as interventional studies to evaluate the impact of AI in VTE.PMID:38574756 | DOI:10.1055/a-2299-4758 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Vasiliki Danilatou Dimitris Dimopoulos Theodoros Kostoulas James Douketis Source Type: research
Clinical impact of dyspnoea after ticagrelor treatment and the effect of switching to clopidogrel in patients with myocardial infarction
CONCLUSIONS: Dyspnoea is a common side effect among ticagrelor-based DAPT in AMI patients. Switching from ticagrelor to clopidogrel after 1 month in AMI patients may provide a reasonable option to alleviate subsequent dyspnoea in ticagrelor-relevant dyspnoeic patients, without increasing the risk of ischaemic events (NCT02018055).PMID:38574757 | DOI:10.1055/a-2299-4537 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sang Hyun Kim Sanghoon Shin Eun Ho Choo Ik Jun Choi Sungmin Lim Donggyu Moon Chan Joon Kim Mahn-Won Park Min Chul Kim Byung-Hee Hwang Kwan Yong Lee Yun-Seok Choi Hee-Yeol Kim Ki-Dong Yoo Doo Soo Jeon Youngkeun Ahn Kiyuk Chang Source Type: research
Transcriptional and functional profiling identifies inflammation and endothelial to mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of Endothelial Colony Forming Cells
CONCLUSION: We observed a range of different RNA expression patterns between ECFC clones mostly associated with inflammation and clear differences in WPB count and structure. We developed a qPCR panel which can be used for the characterization of ECFC clones which is essential for the correct analysis of pathogenic mechanisms in vascular disorders.PMID:38574861 | DOI:10.1016/j.jtha.2024.03.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sebastiaan N J Laan Suzan de Boer Richard J Dirven Iris van Moort Thomas B Kuipers Hailiang Mei Ruben Bierings Jeroen Eikenboom SYMPHONY consortium Source Type: research
Biomarkers of bleeding and venous thromboembolism in patients with acute leukemia
CONCLUSIONS: Our study shows alterations in several biomarkers in acute leukemia and identifies biomarkers associated with risk of bleeding and DVT.PMID:38574862 | DOI:10.1016/j.jtha.2024.03.020 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Yohei Hisada Sierra J Archibald Karan Bansal Yanjun Chen Chen Dai Sindhu Dwarampudi Nora Balas Lindsey Hageman Nigel S Key Smita Bhatia Ravi Bhatia Nigel Mackman Radhika Gangaraju Source Type: research
Communication from the ISTH SSC Subcommittee on Hemostasis and Malignancy: A meta-analysis to assess the risk of bleeding and thrombosis following CAR T-cell therapy
CONCLUSION: The risk of both thrombosis and bleeding following CAR T-cell therapy appears to be highest in the initial months following infusion.PMID:38574863 | DOI:10.1016/j.jtha.2024.03.021 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Poorva Bindal Rushad Patell Thita Chiasakul Mandy N Lauw Amica Ko Tzu-Fei Wang Jeffrey I Zwicker Source Type: research
Noninterventional study assessing joint health in persons with hemophilia A after switching to turoctocog alfa pegol: design of pathfinderReal
CONCLUSION: The pathfinderReal study will provide insights regarding the impact of N8-GP on joint health in persons with hemophilia A in a real-world setting.PMID:38572481 | PMC:PMC10987329 | DOI:10.1016/j.rpth.2024.102363 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Cihan Ay Olga Benitez-Hidalgo Gillian Gidley Maria Elisa Mancuso Davide Matino Azusa Nagao Laszlo Nemes John Waller Johannes Oldenburg Source Type: research
Machine learning-based predictive models for patients with venous thromboembolism: A Systematic Review
CONCLUSION: ML-CPMs show promise in improving risk assessment and individualized treatment recommendations in VTE. Apparently, there is an urgent need for standardized reporting and methodology for ML models, external validation, prospective and real-world data studies, as well as interventional studies to evaluate the impact of AI in VTE.PMID:38574756 | DOI:10.1055/a-2299-4758 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Vasiliki Danilatou Dimitris Dimopoulos Theodoros Kostoulas James Douketis Source Type: research
Clinical impact of dyspnoea after ticagrelor treatment and the effect of switching to clopidogrel in patients with myocardial infarction
CONCLUSIONS: Dyspnoea is a common side effect among ticagrelor-based DAPT in AMI patients. Switching from ticagrelor to clopidogrel after 1 month in AMI patients may provide a reasonable option to alleviate subsequent dyspnoea in ticagrelor-relevant dyspnoeic patients, without increasing the risk of ischaemic events (NCT02018055).PMID:38574757 | DOI:10.1055/a-2299-4537 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sang Hyun Kim Sanghoon Shin Eun Ho Choo Ik Jun Choi Sungmin Lim Donggyu Moon Chan Joon Kim Mahn-Won Park Min Chul Kim Byung-Hee Hwang Kwan Yong Lee Yun-Seok Choi Hee-Yeol Kim Ki-Dong Yoo Doo Soo Jeon Youngkeun Ahn Kiyuk Chang Source Type: research
Transcriptional and functional profiling identifies inflammation and endothelial to mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of Endothelial Colony Forming Cells
CONCLUSION: We observed a range of different RNA expression patterns between ECFC clones mostly associated with inflammation and clear differences in WPB count and structure. We developed a qPCR panel which can be used for the characterization of ECFC clones which is essential for the correct analysis of pathogenic mechanisms in vascular disorders.PMID:38574861 | DOI:10.1016/j.jtha.2024.03.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sebastiaan N J Laan Suzan de Boer Richard J Dirven Iris van Moort Thomas B Kuipers Hailiang Mei Ruben Bierings Jeroen Eikenboom SYMPHONY consortium Source Type: research
