Corrigendum
Res Pract Thromb Haemost. 2022 Oct 28;6(7):e12836. doi: 10.1002/rth2.12836. eCollection 2022 Oct.ABSTRACT[This corrects the article DOI: 10.1002/rth2.12809.].PMID:36320426 | PMC:PMC9615264 | DOI:10.1002/rth2.12836 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - November 2, 2022 Category: Hematology Source Type: research

Antithrombotic treatment switching in elderly patients with atrial fibrillation and the risk of thromboembolism, bleeding, and cardiac death
CONCLUSIONS: Antithrombotic treatment switching is common in the elderly AF population. Importantly, switching to guideline-recommended treatment has a favorable impact on both effectiveness and safety.PMID:36313983 | PMC:PMC9596606 | DOI:10.1002/rth2.12823 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Hanne Ehrlinder Nicola Orsini Karin Modig H åkan Wallén Bruna Gigante Source Type: research

Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes
CONCLUSIONS: Types of F8 mutation were a key predictor of outcomes for low-dose ITI in children with SHA with high-titer inhibitors. It can help to stratify the prognosis and guide clinical decisions.PMID:36313984 | PMC:PMC9606347 | DOI:10.1002/rth2.12824 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Jie Sun Zekun Li Gang Li Kun Huang Di Ai Guoqing Liu Wanru Yao Xingjuan Xie Hao Gu Yingzi Zhen Zhenping Chen Runhui Wu Source Type: research

Standardizing definitions for bleeding events in studies including pregnant women: A call to action
Res Pract Thromb Haemost. 2022 Oct 25;6(7):e12822. doi: 10.1002/rth2.12822. eCollection 2022 Oct.NO ABSTRACTPMID:36313985 | PMC:PMC9596607 | DOI:10.1002/rth2.12822 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Khalid Saeed Fionnuala N í Áinle Source Type: research

Antithrombotic treatment switching in elderly patients with atrial fibrillation and the risk of thromboembolism, bleeding, and cardiac death
CONCLUSIONS: Antithrombotic treatment switching is common in the elderly AF population. Importantly, switching to guideline-recommended treatment has a favorable impact on both effectiveness and safety.PMID:36313983 | PMC:PMC9596606 | DOI:10.1002/rth2.12823 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Hanne Ehrlinder Nicola Orsini Karin Modig H åkan Wallén Bruna Gigante Source Type: research

Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes
CONCLUSIONS: Types of F8 mutation were a key predictor of outcomes for low-dose ITI in children with SHA with high-titer inhibitors. It can help to stratify the prognosis and guide clinical decisions.PMID:36313984 | PMC:PMC9606347 | DOI:10.1002/rth2.12824 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Jie Sun Zekun Li Gang Li Kun Huang Di Ai Guoqing Liu Wanru Yao Xingjuan Xie Hao Gu Yingzi Zhen Zhenping Chen Runhui Wu Source Type: research

Standardizing definitions for bleeding events in studies including pregnant women: A call to action
Res Pract Thromb Haemost. 2022 Oct 25;6(7):e12822. doi: 10.1002/rth2.12822. eCollection 2022 Oct.NO ABSTRACTPMID:36313985 | PMC:PMC9596607 | DOI:10.1002/rth2.12822 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Khalid Saeed Fionnuala N í Áinle Source Type: research

Antithrombotic treatment switching in elderly patients with atrial fibrillation and the risk of thromboembolism, bleeding, and cardiac death
CONCLUSIONS: Antithrombotic treatment switching is common in the elderly AF population. Importantly, switching to guideline-recommended treatment has a favorable impact on both effectiveness and safety.PMID:36313983 | PMC:PMC9596606 | DOI:10.1002/rth2.12823 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Hanne Ehrlinder Nicola Orsini Karin Modig H åkan Wallén Bruna Gigante Source Type: research

Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes
CONCLUSIONS: Types of F8 mutation were a key predictor of outcomes for low-dose ITI in children with SHA with high-titer inhibitors. It can help to stratify the prognosis and guide clinical decisions.PMID:36313984 | PMC:PMC9606347 | DOI:10.1002/rth2.12824 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Jie Sun Zekun Li Gang Li Kun Huang Di Ai Guoqing Liu Wanru Yao Xingjuan Xie Hao Gu Yingzi Zhen Zhenping Chen Runhui Wu Source Type: research

Standardizing definitions for bleeding events in studies including pregnant women: A call to action
Res Pract Thromb Haemost. 2022 Oct 25;6(7):e12822. doi: 10.1002/rth2.12822. eCollection 2022 Oct.NO ABSTRACTPMID:36313985 | PMC:PMC9596607 | DOI:10.1002/rth2.12822 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 31, 2022 Category: Hematology Authors: Khalid Saeed Fionnuala N í Áinle Source Type: research

Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39-R43 of β2-glycoprotein I
CONCLUSIONS: We identified a peptide that selectively bound immunoglobulin G (IgG) derived from APS patients with 100 times more affinity than β2GP1, Domain I, or epitope R39-R43. This peptide is able to inhibit the activity of IgG derived from APS patients in vitro. We have also generated a monoclonal IgG antibody against this peptide. Using both peptide and monoclonal antibody, we have been able to develop a fully standardized indirect colorimetric immunoassay with highly sensitivity. The identification of the optimized peptide offers a new standardized and accurate tool for diagnostics of APS. Furthermore, having incre...
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Marc Moghbel Aline Roth Daniela Baptista Kapka Miteva Fabienne Burger Fabrizio Montecucco Nicolas Vuilleumier Fran çois Mach Karim J Brandt Source Type: research

Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis
CONCLUSIONS: A low concentration of either D123 or E3456, but not of E456, prolonged clot lysis time, and delayed the accumulation of fluorescence-labeled plasminogen at the activated platelets/dense fibrin area due to effective TAFI activation. Conversely, only the highest concentrations of all three TM variants delayed the clotting time, though fibrin network formation in the vicinity of activated platelets was almost intact. TAFI activation might be affected by attenuation in thrombin activity after the clot formation phase. These findings suggest that the spatiotemporal balance between the anticoagulant and antifibrin...
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Liina Mochizuki Hideto Sano Naoki Honkura Kazuma Masumoto Tetsumei Urano Yuko Suzuki Source Type: research

Current Concepts: Comprehensive "Cardiovascular Health" Rehabilitation-An Integrated Approach to Improve Secondary Prevention and Rehabilitation of Cardiovascular Diseases
Thromb Haemost. 2022 Oct 28. doi: 10.1055/s-0042-1757403. Online ahead of print.NO ABSTRACTPMID:36307101 | DOI:10.1055/s-0042-1757403 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Benjamin J R Buckley Gregory Y H Lip Source Type: research

Does Fibrinolytic Strategy of Pulmonary Embolism International ThrOmbolysis (PEITHO)-3 Trial Need More Strong Evidence?
Thromb Haemost. 2022 Oct 28. doi: 10.1055/s-0042-1756356. Online ahead of print.NO ABSTRACTPMID:36307102 | DOI:10.1055/s-0042-1756356 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Olivier Sanchez Stavros V Konstantinides Source Type: research

Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39-R43 of β2-glycoprotein I
CONCLUSIONS: We identified a peptide that selectively bound immunoglobulin G (IgG) derived from APS patients with 100 times more affinity than β2GP1, Domain I, or epitope R39-R43. This peptide is able to inhibit the activity of IgG derived from APS patients in vitro. We have also generated a monoclonal IgG antibody against this peptide. Using both peptide and monoclonal antibody, we have been able to develop a fully standardized indirect colorimetric immunoassay with highly sensitivity. The identification of the optimized peptide offers a new standardized and accurate tool for diagnostics of APS. Furthermore, having incre...
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Marc Moghbel Aline Roth Daniela Baptista Kapka Miteva Fabienne Burger Fabrizio Montecucco Nicolas Vuilleumier Fran çois Mach Karim J Brandt Source Type: research