Tachyphylaxis and reproducibility of desmopressin response in perioperative persons with nonsevere hemophilia A: implications for clinical practice

CONCLUSION: Tachyphylaxis in the surgical setting was considerably more pronounced than previously reported, with FVIII:C at D1 and D2 of 36% to 43% of the initial response. Our results may have important implications for monitoring repeated desmopressin treatment when used perioperatively.PMID:38660455 | PMC:PMC11039391 | DOI:10.1016/j.rpth.2024.102367

Source: Thrombosis and Haemostasis - April 25, 2024 Category: Hematology Authors: L G R Romano L M Sch ütte R M van Hest K Meijer B A P Laros-van Gorkom L Nieuwenhuizen J Eikenboom F C J I Heubel-Moenen N Uitslager M Coppens K Fijnvandraat M H E Driessens S Polinder M H Cnossen F W G Leebeek R A A Math ôt M J H A Kruip DAVID and SYMP Source Type: research