Mathematical models of coagulation - Are we there yet?
CONCLUSIONS: This systematic assessment of models of coagulation, using large dataset inputs, points to ways in which these models can be improved. A model that accurately reflects the effects of the multiple, subtle variations in an individual's haemostatic profile could be used for assessing antithrombotics or as a tool for precision medicine.PMID:38521192 | DOI:10.1016/j.jtha.2024.03.009 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 23, 2024 Category: Hematology Authors: Matt J Owen Joy R Wright Edward G D Tuddenham John R King Alison H Goodall Joanne L Dunster Source Type: research
Education
J Thromb Haemost. 2024 Apr;22(4):895. doi: 10.1016/j.jtha.2024.02.002.NO ABSTRACTPMID:38521576 | DOI:10.1016/j.jtha.2024.02.002 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 23, 2024 Category: Hematology Authors: Ton Lisman Suzanne C Cannegieter Source Type: research
Hemorrhagic transformation after acute ischemic stroke thrombolysis treatment: navigating the landscape of hemostasis genetic risk factors
J Thromb Haemost. 2024 Apr;22(4):919-921. doi: 10.1016/j.jtha.2024.01.002.NO ABSTRACTPMID:38521577 | DOI:10.1016/j.jtha.2024.01.002 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 23, 2024 Category: Hematology Authors: Zsuzsa Bagoly Source Type: research
Lower-dose emicizumab prophylaxis: can less be more?
J Thromb Haemost. 2024 Apr;22(4):922-925. doi: 10.1016/j.jtha.2024.01.018.NO ABSTRACTPMID:38521578 | DOI:10.1016/j.jtha.2024.01.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 23, 2024 Category: Hematology Authors: Alok Srivastava Alfonso Iorio Source Type: research
Will the real authors please stand up
J Thromb Haemost. 2024 Mar 18:S1538-7836(24)00165-X. doi: 10.1016/j.jtha.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38521666 | DOI:10.1016/j.jtha.2024.03.007 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 23, 2024 Category: Hematology Authors: Ton Lisman Suzanne C Cannegieter Source Type: research
Nonacog beta pegol prophylaxis in children with hemophilia B: safety, efficacy, and neurodevelopmental outcomes for up to 8 years
CONCLUSION: These data provide the longest follow-up for an extended half-life FIX and confirm the long-term efficacy of N9-GP prophylaxis in children with HB with no observed neurocognitive or neurologic safety concerns.PMID:38516633 | PMC:PMC10955654 | DOI:10.1016/j.rpth.2024.102341 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Karin S Walsh Christine Mrakotsky Manuel Carcao Anthony K C Chan Pernille H øjlund Nielsen Helle Holst Kevin Shapiro Source Type: research
L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the COX-2 inhibitor parecoxib
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00164-8. doi: 10.1016/j.jtha.2024.03.006. Online ahead of print.NO ABSTRACTPMID:38518895 | DOI:10.1016/j.jtha.2024.03.006 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Ricky Vaja Maria Lopes-Pires Fisnik Shala Neringa Cypaite Maria Vinokurova Plinio Ferreira Jane A Mitchell Nicholas S Kirkby Source Type: research
Standardisation of Definition and Management for Bleeding Disorder of Unknown Cause: Communication from the SSC of the ISTH
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00163-6. doi: 10.1016/j.jtha.2024.03.005. Online ahead of print.ABSTRACTIn many patients referred with significant bleeding phenotype, laboratory testing fails to define any hemostatic abnormalities. Clinical practise with respect to diagnosis and management of this patient cohort poses significant clinical challenges. We recommend that bleeding history in these patients should be objectively assessed using the ISTH bleeding assessment tool (BAT). Patients with increased BAT scores should progress to hemostasis laboratory testing. To diagnose BDUC, normal complete blood count, pr...
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Ross I Baker Philip Choi Nicola Curry Johanna Gebhart Keith Gomez Yvonne Henskens Floor Heubel-Moenen Paula James Rezan Abdul Kadir Peter Kouides Michelle Lavin Marie Lordkipanidze Gillian Lowe Andrew Mumford Nicola Mutch Michael Nagler Maha Othman Ingrid Source Type: research
Recent Advances in Vascular Thiol Isomerases and Redox Systems in Platelet Function and Thrombosis
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00166-1. doi: 10.1016/j.jtha.2024.03.008. Online ahead of print.ABSTRACTThere have been substantial advances in vascular protein disulfide isomerases (PDIs) in platelet function and thrombosis in recent years. There are four known prothrombotic thiol isomerases, PDI, ERp57, ERp72, ERp46 and one antithrombotic PDI, transmembrane protein 1 (TMX1). A sixth PDI, ERp5, may exhibit either pro- or anti-thrombotic properties in platelets. Studies on ERp46 in platelet function and thrombosis provide insight into the mechanisms by which these enzymes function. ERp46-catalyzed disulfide cle...
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: David W Essex Lu Wang Source Type: research
Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo
CONCLUSION: This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.PMID:38519039 | DOI:10.1055/s-0044-1782182 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Hongmei Zhu Richard L Auten Augustus Richard Whorton Stanley Nicholas Mason Cheryl B Bock Gary T Kucera Zachary T Kelleher Aaron T Vose Tim J McMahon Source Type: research
Nonacog beta pegol prophylaxis in children with hemophilia B: safety, efficacy, and neurodevelopmental outcomes for up to 8 years
CONCLUSION: These data provide the longest follow-up for an extended half-life FIX and confirm the long-term efficacy of N9-GP prophylaxis in children with HB with no observed neurocognitive or neurologic safety concerns.PMID:38516633 | PMC:PMC10955654 | DOI:10.1016/j.rpth.2024.102341 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Karin S Walsh Christine Mrakotsky Manuel Carcao Anthony K C Chan Pernille H øjlund Nielsen Helle Holst Kevin Shapiro Source Type: research
L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the COX-2 inhibitor parecoxib
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00164-8. doi: 10.1016/j.jtha.2024.03.006. Online ahead of print.NO ABSTRACTPMID:38518895 | DOI:10.1016/j.jtha.2024.03.006 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Ricky Vaja Maria Lopes-Pires Fisnik Shala Neringa Cypaite Maria Vinokurova Plinio Ferreira Jane A Mitchell Nicholas S Kirkby Source Type: research
Standardisation of Definition and Management for Bleeding Disorder of Unknown Cause: Communication from the SSC of the ISTH
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00163-6. doi: 10.1016/j.jtha.2024.03.005. Online ahead of print.ABSTRACTIn many patients referred with significant bleeding phenotype, laboratory testing fails to define any hemostatic abnormalities. Clinical practise with respect to diagnosis and management of this patient cohort poses significant clinical challenges. We recommend that bleeding history in these patients should be objectively assessed using the ISTH bleeding assessment tool (BAT). Patients with increased BAT scores should progress to hemostasis laboratory testing. To diagnose BDUC, normal complete blood count, pr...
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Ross I Baker Philip Choi Nicola Curry Johanna Gebhart Keith Gomez Yvonne Henskens Floor Heubel-Moenen Paula James Rezan Abdul Kadir Peter Kouides Michelle Lavin Marie Lordkipanidze Gillian Lowe Andrew Mumford Nicola Mutch Michael Nagler Maha Othman Ingrid Source Type: research
Recent Advances in Vascular Thiol Isomerases and Redox Systems in Platelet Function and Thrombosis
J Thromb Haemost. 2024 Mar 20:S1538-7836(24)00166-1. doi: 10.1016/j.jtha.2024.03.008. Online ahead of print.ABSTRACTThere have been substantial advances in vascular protein disulfide isomerases (PDIs) in platelet function and thrombosis in recent years. There are four known prothrombotic thiol isomerases, PDI, ERp57, ERp72, ERp46 and one antithrombotic PDI, transmembrane protein 1 (TMX1). A sixth PDI, ERp5, may exhibit either pro- or anti-thrombotic properties in platelets. Studies on ERp46 in platelet function and thrombosis provide insight into the mechanisms by which these enzymes function. ERp46-catalyzed disulfide cle...
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: David W Essex Lu Wang Source Type: research
Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo
CONCLUSION: This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.PMID:38519039 | DOI:10.1055/s-0044-1782182 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Hongmei Zhu Richard L Auten Augustus Richard Whorton Stanley Nicholas Mason Cheryl B Bock Gary T Kucera Zachary T Kelleher Aaron T Vose Tim J McMahon Source Type: research
