Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis
CONCLUSIONS: A low concentration of either D123 or E3456, but not of E456, prolonged clot lysis time, and delayed the accumulation of fluorescence-labeled plasminogen at the activated platelets/dense fibrin area due to effective TAFI activation. Conversely, only the highest concentrations of all three TM variants delayed the clotting time, though fibrin network formation in the vicinity of activated platelets was almost intact. TAFI activation might be affected by attenuation in thrombin activity after the clot formation phase. These findings suggest that the spatiotemporal balance between the anticoagulant and antifibrin...
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Liina Mochizuki Hideto Sano Naoki Honkura Kazuma Masumoto Tetsumei Urano Yuko Suzuki Source Type: research

Current Concepts: Comprehensive "Cardiovascular Health" Rehabilitation-An Integrated Approach to Improve Secondary Prevention and Rehabilitation of Cardiovascular Diseases
Thromb Haemost. 2022 Oct 28. doi: 10.1055/s-0042-1757403. Online ahead of print.NO ABSTRACTPMID:36307101 | DOI:10.1055/s-0042-1757403 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Benjamin J R Buckley Gregory Y H Lip Source Type: research

Does Fibrinolytic Strategy of Pulmonary Embolism International ThrOmbolysis (PEITHO)-3 Trial Need More Strong Evidence?
Thromb Haemost. 2022 Oct 28. doi: 10.1055/s-0042-1756356. Online ahead of print.NO ABSTRACTPMID:36307102 | DOI:10.1055/s-0042-1756356 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Olivier Sanchez Stavros V Konstantinides Source Type: research

Epitope of antiphospholipid antibodies retrieved from peptide microarray based on R39-R43 of β2-glycoprotein I
CONCLUSIONS: We identified a peptide that selectively bound immunoglobulin G (IgG) derived from APS patients with 100 times more affinity than β2GP1, Domain I, or epitope R39-R43. This peptide is able to inhibit the activity of IgG derived from APS patients in vitro. We have also generated a monoclonal IgG antibody against this peptide. Using both peptide and monoclonal antibody, we have been able to develop a fully standardized indirect colorimetric immunoassay with highly sensitivity. The identification of the optimized peptide offers a new standardized and accurate tool for diagnostics of APS. Furthermore, having incre...
Source: Thrombosis and Haemostasis - October 28, 2022 Category: Hematology Authors: Marc Moghbel Aline Roth Daniela Baptista Kapka Miteva Fabienne Burger Fabrizio Montecucco Nicolas Vuilleumier Fran çois Mach Karim J Brandt Source Type: research

Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease
DISCUSSION: The risk of an acute episode triggered by COVID-19 seems higher than following vaccination in hTTP patients, who can be safely vaccinated against SARS-CoV-2.PMID:36284639 | PMC:PMC9585384 | DOI:10.1002/rth2.12814 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 26, 2022 Category: Hematology Authors: Erika Tarasco Anne Sophie von Krogh Radomira Hrdlickova Thomas R Braschler Teresa Iwaniec Paul N Kn öbl Eriko Hamada Oleg Pikovsky Stefan Farese Odit Gutwein Petr Kessler Nina H Schultz Charis von Auer Jerzy Windyga Kenneth Friedman Ingrid Hrachovinova J Source Type: research

Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease
DISCUSSION: The risk of an acute episode triggered by COVID-19 seems higher than following vaccination in hTTP patients, who can be safely vaccinated against SARS-CoV-2.PMID:36284639 | PMC:PMC9585384 | DOI:10.1002/rth2.12814 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 26, 2022 Category: Hematology Authors: Erika Tarasco Anne Sophie von Krogh Radomira Hrdlickova Thomas R Braschler Teresa Iwaniec Paul N Kn öbl Eriko Hamada Oleg Pikovsky Stefan Farese Odit Gutwein Petr Kessler Nina H Schultz Charis von Auer Jerzy Windyga Kenneth Friedman Ingrid Hrachovinova J Source Type: research

"ISTH guidelines for antithrombotic treatment in COVID-19": Comment from Huisman et al
J Thromb Haemost. 2022 Nov;20(11):2708-2709. doi: 10.1111/jth.15855.NO ABSTRACTPMID:36271456 | DOI:10.1111/jth.15855 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Menno V Huisman Frederikus A Klok Pieter W Kamphuisen Source Type: research

"ISTH guidelines for antithrombotic treatment in COVID-19": Reply
J Thromb Haemost. 2022 Nov;20(11):2710-2711. doi: 10.1111/jth.15854.NO ABSTRACTPMID:36271457 | DOI:10.1111/jth.15854 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Sam Schulman Michelle Sholzberg Alex C Spyropoulos Ryan Zarychanski Source Type: research

"Vaccine-induced immune thrombotic thrombocytopenia (VITT)-Update on diagnosis and management considering different resources": Comment
J Thromb Haemost. 2022 Nov;20(11):2707-2708. doi: 10.1111/jth.15853.NO ABSTRACTPMID:36271458 | DOI:10.1111/jth.15853 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Maria Elena Paez Alacron Andreas Greinacher Source Type: research

"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: Guidance from the SSC of the ISTH": Reply
J Thromb Haemost. 2022 Nov;20(11):2713-2714. doi: 10.1111/jth.15859.NO ABSTRACTPMID:36271459 | DOI:10.1111/jth.15859 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Lara N Roberts Ton Lisman Simon Stanworth Virginia Hernandez-Gea Maria Magnusson Armando Tripodi Jecko Thachil Source Type: research

"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: Guidance from the SSC of the ISTH": Comment from Hartmann et al
J Thromb Haemost. 2022 Nov;20(11):2711-2712. doi: 10.1111/jth.15861.NO ABSTRACTPMID:36271460 | DOI:10.1111/jth.15861 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Jan Hartmann Joao D Dias Guadalupe Garcia-Tsao Evan G Pivalizza Source Type: research

What the neighbors say
J Thromb Haemost. 2022 Nov;20(11):2456. doi: 10.1111/jth.15900.NO ABSTRACTPMID:36271461 | DOI:10.1111/jth.15900 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Source Type: research

"Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Reply
J Thromb Haemost. 2022 Nov;20(11):2717-2718. doi: 10.1111/jth.15869.NO ABSTRACTPMID:36271462 | DOI:10.1111/jth.15869 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Zachary A Matthay Alexander T Fields Lucy Z Kornblith Source Type: research

"Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Comment
J Thromb Haemost. 2022 Nov;20(11):2715-2716. doi: 10.1111/jth.15868.NO ABSTRACTPMID:36271463 | DOI:10.1111/jth.15868 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Gordon Oluoch Ogweno Source Type: research

Can KCa3.1 channel activators serve as novel inhibitors of platelet aggregation?
J Thromb Haemost. 2022 Nov;20(11):2488-2490. doi: 10.1111/jth.15863.NO ABSTRACTPMID:36271464 | DOI:10.1111/jth.15863 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2022 Category: Hematology Authors: Heike Wulff Andrew P Braun Seth L Alper Source Type: research