Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: a prospective analysis of 302 procedures
CONCLUSIONS: An extensive hemostasis workup, including global hemostasis assays, does not improve prediction of liver biopsy-related bleeding. Pain 2 hours after liver biopsy should alert the clinician to the possibility of procedure-related bleeding.PMID:36128757 | DOI:10.1111/jth.15888 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 21, 2022 Category: Hematology Authors: Julien Bissonnette Alix Riescher-Tuczkiewicz Elia Gigante Carole Bourdin Boudaoud Larbi Heithem Soliman Fran çois Durand Maxime Ronot Dominique Valla Val érie Vilgrain Emmanuelle de Raucourt Pierre-Emmanuel Rautou Source Type: research

ADAMTS13 inhibition to treat acquired von Willebrand syndrome during mechanical circulatory support device implantation
CONCLUSION: Hence, inhibition of ADAMTS13 could become a novel therapeutic strategy to manage aVWS in MCS device patients.PMID:36128768 | DOI:10.1111/jth.15889 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 21, 2022 Category: Hematology Authors: Shannen J Deconinck Christoph Nix Svenja Barth Eveline Bennek-Sch öpping Antoine Rauch An-Sofie Schelpe Elien Roose Hendrik B Feys Inge Pareyn Aline Vandenbulcke Joshua Muia Christophe Vandenbriele Sophie Susen Bart Meyns Claudia Tersteeg Steven Jacobs S Source Type: research

Achieving higher efficacy without compromising safety with Factor XI inhibitors versus low-molecular-weight heparin for the prevention of venous thromboembolism in major orthopedic surgery - Systematic Review and Meta-Analysis
CONCLUSION: Factor XI inhibitors showed a significant reduction in the incidence of VTE and bleeding events among patients submitted to major orthopedic surgery.PMID:36128769 | DOI:10.1111/jth.15890 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 21, 2022 Category: Hematology Authors: Jo ão Presume Jorge Ferreira Regina Ribeiras Miguel Mendes Source Type: research

Bifunctional effect of the inflammatory cytokine TNF α on megakaryopoiesis and platelet production
CONCLUSIONS: Our study revealed distinct roles for TNFα in megakaryopoiesis and thrombopoiesis and may provide new insights regarding the treatment for platelet disorders.PMID:36128771 | DOI:10.1111/jth.15891 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 21, 2022 Category: Hematology Authors: Tiantian Chu Shuhong Hu Jiaqian Qi Xueqian Li Xiang Zhang Yaqiong Tang Meng Yang Yang Xu Changgeng Ruan Yue Han Depei Wu Source Type: research

How often are parenteral anticoagulants administered by parents?
J Thromb Haemost. 2022 Sep 21. doi: 10.1111/jth.15887. Online ahead of print.ABSTRACTParenteral anticoagulants are a class of anticoagulants that need to be administered non-orally, usually by injection or infusion. There are a variety of such agents, but heparin reflects the most frequently used. Being alerted to an error in a prior publication in which the word 'parenteral' was inadvertently replaced by the word 'parental', it became clear that even experienced authors make such errors, which could then remain undetected by reviewers and editors, thus leading to failure in correction of same before publication. Given thi...
Source: Thrombosis and Haemostasis - September 21, 2022 Category: Hematology Authors: Emmanuel J Favaloro Leonardo Pasalic Giuseppe Lippi Source Type: research

Uric Acid induces a pro-atherothrombotic phenotype in human endothelial cells by imbalancing TF/TFPI pathway
CONCLUSIONS: The present in vitro study, shows that one of the mechanisms by which high levels of UA contributes to ED might be the imbalance between TF/TFPI levels in endothelial cells, shifting them to a non-physiological, pro-thrombotic phenotype. These UA effects might hypothetically explain, at least in part, the relationship observed between elevated plasma levels of UA and cardiovascular events.PMID:36126947 | DOI:10.1055/a-1947-7716 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 20, 2022 Category: Hematology Authors: Giovanni Cimmino Stefano Conte Laura Marra Andrea Morello Mariarosaria Morello Gennaro De Rosa Martino Pepe Akmetzhan Sugralyev Paolo Golino Plinio Cirillo Source Type: research

Dual specificity tyrosine phosphorylation regulated kinase 1B inhibition promotes megakaryocyte polyploidization and platelet production
The objective of this study was to determine DYRK1B function in megakaryocyte maturation and platelet production. A DYRK1B knock out mouse (DYKO) was generated with increased peripheral platelet count compared to the wild type (WT) mouse without affecting megakaryocyte numbers in bone marrow. Polyploidy and proplatelet formation were significantly enhanced when DYRK1B was depleted in vitro. DYRK1B inhibition promoted megakaryocyte maturation by simultaneously upregulating cyclin D1 and downregulating P27. Furthermore, there was platelet restoration in two mice disease models of transient thrombocytopenia. In summary, DYRK1...
Source: Thrombosis and Haemostasis - September 20, 2022 Category: Hematology Authors: Jiaxin Zhao Yanyan Xu Jiqiu Wang Junling Liu Ruiyan Zhang Xiaoxiang Yan Source Type: research

Development and internal validation of a clinical prediction model for the diagnosis of immune thrombocytopenia
CONCLUSIONS: The Predict-ITP Tool can estimate the likelihood of ITP for a given patient with thrombocytopenia at the time of the initial hematology consultation. The tool had high predictive accuracy for the diagnosis of ITP.PMID:36121734 | DOI:10.1111/jth.15885 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: Na Li Syed Mahamad Sameer Parpia Alfonso Iorio Farid Foroutan Nancy M Heddle Cyrus C Hsia Michelle Sholzberg Emily Rimmer Sudeep Shivakumar Haowei Linda Sun Mohammad Refaei Caroline Hamm Donald M Arnold Source Type: research

A Trp11Arg Substitution in the β3 Signal Peptide Prevents Expression of αIIbβ3 in Patients with Glanzmann Thrombasthenia
Thromb Haemost. 2022 Sep 19. doi: 10.1055/s-0042-1756450. Online ahead of print.NO ABSTRACTPMID:36122578 | DOI:10.1055/s-0042-1756450 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: Yannick Waxmann Miriam Arians Gregor Bein Ulrich J Sachs Behnaz Bayat Source Type: research

"A personalized limited sampling approach to better estimate terminal half-life of FVIII concentrates": Comment from Huang et al
J Thromb Haemost. 2022 Oct;20(10):2444-2445. doi: 10.1111/jth.15833.NO ABSTRACTPMID:36123571 | DOI:10.1111/jth.15833 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: Kun Huang Zhenping Chen Runhui Wu Source Type: research

What the neighbors say
J Thromb Haemost. 2022 Oct;20(10):2170. doi: 10.1111/jth.15857.NO ABSTRACTPMID:36123572 | DOI:10.1111/jth.15857 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Source Type: research

The future of basic science research into a leading cause of disability and death
J Thromb Haemost. 2022 Oct;20(10):2167-2169. doi: 10.1111/jth.15851.NO ABSTRACTPMID:36123573 | DOI:10.1111/jth.15851 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: James H Morrissey David Lillicrap Source Type: research

Commentary on "The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1"
J Thromb Haemost. 2022 Oct;20(10):2211-2213. doi: 10.1111/jth.15839.NO ABSTRACTPMID:36123574 | DOI:10.1111/jth.15839 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: Fien A von Meijenfeldt Source Type: research

Identification of outcomes in clinical studies of interventions for venous thromboembolism in non-pregnant adults
J Thromb Haemost. 2022 Oct;20(10):2204-2206. doi: 10.1111/jth.15849.NO ABSTRACTPMID:36123575 | DOI:10.1111/jth.15849 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Authors: Francis Couturaud Christophe Leroyer C écile Tromeur Source Type: research

Corrigendum
J Thromb Haemost. 2022 Oct;20(10):2446-2447. doi: 10.1111/jth.15838.NO ABSTRACTPMID:36123576 | DOI:10.1111/jth.15838 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - September 19, 2022 Category: Hematology Source Type: research