Density-based lipoprotein depletion improves extracellular vesicle isolation and functional analysis
CONCLUSION: Combination of G-UC+SEC significantly reduced EV lipoprotein contamination without interfering in EV cellular source, gene ontology and ultrastructure, allowing the obtention of highly pure EVs with potential implications for functional assays, proteomic and lipidomic analysis.PMID:38278418 | DOI:10.1016/j.jtha.2024.01.010 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 26, 2024 Category: Hematology Authors: Laura Botelho Merij Luana Rocha da Silva Lohanna Palhinha Milena Tavares Gomes Paula Ribeiro Braga Dib Remy Martins-Gon çalves Kemily Toledo-Quiroga Marcus Ant ônio Raposo-Nunes Fernanda Brandi Andrade Sharon de Toledo Martins Ana L úcia Rosa Nasciment Source Type: research
< em > In vitro < /em > characterization of rare anti- α < sub > IIb < /sub > β < sub > 3 < /sub > isoantibodies produced by patients with Glanzmann thrombasthenia that severely block fibrinogen binding and generate procoagulant platelets via complement activation
CONCLUSION: Our data suggest that complement activation induced by rare blocking anti-αIIbβ3 isoantibodies may lead to the formation of a MAC with subsequent pore formation, resulting in calcium influx and procoagulant platelet phenotype.PMID:38268518 | PMC:PMC10805943 | DOI:10.1016/j.rpth.2023.102253 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 25, 2024 Category: Hematology Authors: Christine S M Lee Yoann Huguenin Xavier Pillois Mikeldi Moulieras Ella Marcy Shane Whittaker Vivien M Y Chen Mathieu Fiore Source Type: research
Venous thromboembolism, chronic liver disease and anticoagulant choice: effectiveness and safety of direct oral anticoagulants versus warfarin
CONCLUSION: While the magnitude of clinical benefit varied across individual DOACs, in adults with acute VTE and chronic liver disease, oral factor Xa inhibitors (as a class or individually) were associated with lower risk of recurrent VTE and major bleeding.PMID:38268519 | PMC:PMC10805675 | DOI:10.1016/j.rpth.2023.102293 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 25, 2024 Category: Hematology Authors: Oluwadolapo D Lawal Herbert D Aronow Anne L Hume Fisayomi Shobayo Kelly L Matson Marilyn Barbour Yichi Zhang Xuerong Wen Source Type: research
Effects of antiplatelet therapy on menstrual blood loss in reproductive-aged women: a systematic review
CONCLUSION: There is lack of high-quality data on the effects of antiplatelet therapy on menstrual bleeding. Aspirin may increase menstrual blood loss, at least in a minority of women, whereas the effects of P2Y12 inhibitors are unknown.PMID:38268520 | PMC:PMC10805676 | DOI:10.1016/j.rpth.2023.102295 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 25, 2024 Category: Hematology Authors: Eva K Kempers Johanna A van der Zande Paula M Janssen J érôme M J Cornette Jolien W Roos-Hesselink Marieke J H A Kruip Source Type: research
von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis
CONCLUSION: VWF:RCo/VWF:Ag ratios of <0.7 may indicate loss of VWF large multimers with high specificity, but low sensitivity. VWF:RCo/VWF:Ag ratios in patients with AS having a ratio of <0.7 may be useful for monitoring the loss of VWF large multimers during their clinical courses.PMID:38268521 | PMC:PMC10805667 | DOI:10.1016/j.rpth.2023.102284 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 25, 2024 Category: Hematology Authors: Noriyuki Okubo Shingo Sugawara Tohru Fujiwara Ko Sakatsume Tsuyoshi Doman Mihoko Yamashita Kota Goto Masaki Tateishi Misako Suzuki Ryutaro Shirakawa Yuka Eura Koichi Kokame Masaki Hayakawa Masanori Matsumoto Yasunori Kawate Mizuki Miura Hiroshi Takiguchi Source Type: research
