Anticoagulation in atrial fibrillation and end-stage kidney disease on hemodialysis: a meta-analysis of randomized trials comparing direct oral anticoagulants with vitamin K antagonists
CONCLUSION: Orally administered activated factor X inhibitors carried a similar risk of bleeding and death when compared with VKAs in patients with NVAF undergoing chronic hemodialysis. Moreover, there was a trend towards a reduction of thromboembolic events or stroke in patients receiving DOACs.PMID:38404942 | PMC:PMC10885786 | DOI:10.1016/j.rpth.2024.102332 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Maximilian Tscharre Daniel Steiner David Mutschlechner Cihan Ay Thomas Gremmel Source Type: research
Primary prevention of venous thromboembolism for cancer patients in randomized controlled trials: a bibliographical analysis of funding and trial characteristics
CONCLUSION: There were few significant differences between trial characteristics, suggesting that the evidence from commercially sponsored trials investigating VTE prophylaxis in patients with cancer is unlikely to be subject to bias attributable to commercial sponsorship.PMID:38404943 | PMC:PMC10884502 | DOI:10.1016/j.rpth.2024.102315 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Lucy Zhao Jayhan Kherani Pei Ye Li Kevin Zhang Angelina Horta Christine Lin Allen Li Ali Eshaghpour Mark Andrew Crowther Source Type: research
Comparison of different algorithms for lupus anticoagulant detection: a single-center experience
CONCLUSION: All laboratory algorithms showed equivalent diagnostic performance. Establishing the best method of interpretation for each assay is recommended to improve LA detection performance.PMID:38404944 | PMC:PMC10885790 | DOI:10.1016/j.rpth.2024.102333 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Dollapak Apipongrat Rattapan Lamool Pasra Arnutti Chetana Ruangpratheep Wittawat Chantkran Source Type: research
Impact of adverse pregnancy outcomes on brain vascular health and cognition
Res Pract Thromb Haemost. 2024 Jan 30;8(1):102331. doi: 10.1016/j.rpth.2024.102331. eCollection 2024 Jan.ABSTRACTA State of the Art lecture titled "Impact of Adverse Pregnancy Outcomes on Brain Vascular Health and Cognition" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Adverse pregnancy outcomes, encompassing conditions such as gestational hypertension, eclampsia, preeclampsia, preterm birth, fetal growth restriction, stillbirth, and gestational diabetes, may form part of an underrecognized pathway from early adulthood reproductive health factors to later-life vascular cognitiv...
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Katrin Wolfova Eliza C Miller Source Type: research
Is glycoprotein VI involved in contractual negotiations?
Res Pract Thromb Haemost. 2024 Jan 26;8(1):102329. doi: 10.1016/j.rpth.2024.102329. eCollection 2024 Jan.NO ABSTRACTPMID:38404946 | PMC:PMC10883811 | DOI:10.1016/j.rpth.2024.102329 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Simone A Brysland James I Hearn Elizabeth E Gardiner Source Type: research
A novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum
CONCLUSIONS: The resulting clot contraction dynamics based on the expulsion of FITC-albumin can be quantified using a number of kinetic parameters as well as a phase kinetics analysis. The advantages and drawbacks of the new technique are discussed.PMID:38401713 | DOI:10.1016/j.jtha.2024.02.012 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 24, 2024 Category: Hematology Authors: Alina D Peshkova John W Weisel Rustem I Litvinov Source Type: research
A novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum
CONCLUSIONS: The resulting clot contraction dynamics based on the expulsion of FITC-albumin can be quantified using a number of kinetic parameters as well as a phase kinetics analysis. The advantages and drawbacks of the new technique are discussed.PMID:38401713 | DOI:10.1016/j.jtha.2024.02.012 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 24, 2024 Category: Hematology Authors: Alina D Peshkova John W Weisel Rustem I Litvinov Source Type: research
Comparison of thrombotic adverse events in patients treated with factor VIII products and emicizumab using the 2018-2022 FAERS data
CONCLUSION: Thrombotic AEs in the FAERS data were about three times more frequently reported for emicizumab than for FVIII products. More research and efforts in the future are warranted for monitoring, elucidating, and preventing the potential risk of thrombotic AEs of hemophilia therapy, including emicizumab.PMID:38395359 | DOI:10.1016/j.jtha.2024.02.009 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 23, 2024 Category: Hematology Authors: Hyunjeong Cho Ki Young Yoo Ju-Young Shin Eun-Kyoung Lee BongKyoo Choi Source Type: research
Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi
CONCLUSIONS: As in NETosis, PAD4 can catalyze the formation of EETs. Inhibition of PAD4 decreases EET formation, supporting the future utility of PAD4 inhibitors as possible antithrombotic agents.PMID:38395360 | DOI:10.1016/j.jtha.2024.02.010 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 23, 2024 Category: Hematology Authors: Kimberly Martinod Frederik Denorme Severien Meyers Marilena Crescente Stijn Van Bruggen Mathias Stroobants Patrick M Siegel Ramesh Grandhi Katharina Glatz Thilo Witsch Source Type: research
Bleeding events in thrombotic antiphospholipid syndrome: prevalence, severity, and associated damage accrual
CONCLUSION: Approximately 40% of patients experienced at least 1 bleeding, and almost 8% of patients were left with organ damage not recognized by the current version of the Damage Index for Antiphospholipid Syndrome.PMID:38384985 | PMC:PMC10879794 | DOI:10.1016/j.rpth.2024.102327 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 22, 2024 Category: Hematology Authors: Pedro Gaspar Prabal Mittal Hannah Cohen David A Isenberg Source Type: research
No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study
CONCLUSION: Evidence from both univariate and multivariable MR analyses demonstrated no significant causal relationships between current and past tobacco smoking and VTE, DVT, and PE. This contradicts positive correlations reported in some previous observational studies, which may be explained by other confounding factors. This provided genetic evidence for the conclusion reported in other observational studies that smoking did not affect VTE risk.PMID:38387601 | DOI:10.1055/s-0044-1781425 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 22, 2024 Category: Hematology Authors: Hong-Cheng Du Yun-Fei Zheng Meng-Qi Shen Bai-Yang Deng Source Type: research
Bleeding events in thrombotic antiphospholipid syndrome: prevalence, severity, and associated damage accrual
CONCLUSION: Approximately 40% of patients experienced at least 1 bleeding, and almost 8% of patients were left with organ damage not recognized by the current version of the Damage Index for Antiphospholipid Syndrome.PMID:38384985 | PMC:PMC10879794 | DOI:10.1016/j.rpth.2024.102327 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 22, 2024 Category: Hematology Authors: Pedro Gaspar Prabal Mittal Hannah Cohen David A Isenberg Source Type: research
No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study
CONCLUSION: Evidence from both univariate and multivariable MR analyses demonstrated no significant causal relationships between current and past tobacco smoking and VTE, DVT, and PE. This contradicts positive correlations reported in some previous observational studies, which may be explained by other confounding factors. This provided genetic evidence for the conclusion reported in other observational studies that smoking did not affect VTE risk.PMID:38387601 | DOI:10.1055/s-0044-1781425 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 22, 2024 Category: Hematology Authors: Hong-Cheng Du Yun-Fei Zheng Meng-Qi Shen Bai-Yang Deng Source Type: research
Bleeding events in thrombotic antiphospholipid syndrome: prevalence, severity, and associated damage accrual
CONCLUSION: Approximately 40% of patients experienced at least 1 bleeding, and almost 8% of patients were left with organ damage not recognized by the current version of the Damage Index for Antiphospholipid Syndrome.PMID:38384985 | PMC:PMC10879794 | DOI:10.1016/j.rpth.2024.102327 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 22, 2024 Category: Hematology Authors: Pedro Gaspar Prabal Mittal Hannah Cohen David A Isenberg Source Type: research
Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction
CONCLUSION: Our findings highlight the importance of both active contractile and passive crosslinking roles of myosin IIA in the platelet cytoskeleton. They support the hypothesis that highly contractile platelets are needed for hemostasis and further suggest a supportive role for myosin IIA in GPVI signaling.PMID:38379711 | PMC:PMC10877441 | DOI:10.1016/j.rpth.2024.102322 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 21, 2024 Category: Hematology Authors: Martin Kenny Alice Y Pollitt Smita Patil Dishon W Hiebner Albert Smolenski Natalija Lakic Robert Fisher Reema Alsufyani Sebastian Lickert Viola Vogel Ingmar Schoen Source Type: research
