Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation

CONCLUSION: Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.PMID:38653482 | DOI:10.1055/a-2311-0117

Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Pengyu Zhang Saskia von Ungern-Sternberg Luisa Hastenplug Fiorella Solari Albert Sickmann Marijke Kuijpers Johan Wm Heemskerk Ulrich Walter Kerstin Jurk Source Type: research