Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
In this study, we established Golli-myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli-myelin basic protein knockout through the generation of conditional knockout mice (Golli-myelin basic proteinsfl/fl; E3CreN), in which Golli-myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli-myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli-myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degenerat...
Source: Transgenic Research - April 29, 2024 Category: Genetics & Stem Cells Authors: Haruko Miyazaki Saki Nishioka Tomoyuki Yamanaka Manabu Abe Yukio Imamura Tomohiro Miyasaka Nobuto Kakuda Toshitaka Oohashi Tomomi Shimogori Kazuhiro Yamakawa Masahito Ikawa Nobuyuki Nukina Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
Regulatory landscape and public perception for gene-edited bananas in the Southeast Asian region
Transgenic Res. 2024 Apr 10. doi: 10.1007/s11248-024-00379-9. Online ahead of print.ABSTRACTBanana is a premier fruit crop in many parts of the world especially Southeast Asia. The demand for banana has contributed to significant national income to primary banana producers in the SEA region such as the Philippines, Indonesia, Thailand, Vietnam, and Malaysia. However, the widely traded banana industry is plagued by numerous threats including pests and diseases, post-harvest issues and extreme climate vulnerability. To address these challenges, new breeding techniques such as gene editing have been explored for breeding prog...
Source: Transgenic Research - April 10, 2024 Category: Genetics & Stem Cells Authors: Nurzatil Sharleeza Mat Jalaluddin Abdulah Al-Hadi Ahmad Fuaad Rofina Yasmin Othman Source Type: research
