Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Int Immunopharmacol. 2024 May 2;134:112171. doi: 10.1016/j.intimp.2024.112171. Online ahead of print.ABSTRACTProstate cancer represents the second most prevalent form of cancer found in males, and stands as the fifth primary contributor to cancer-induced mortality on a global scale. Research has shown that transplanted mesenchymal stem cells (MSCs) can migrate by homing to tumor sites in the body. In prostate cancer, researchers have explored the fact that MSC-based therapies (including genetically modified delivery vehicles or vectors) and MSC-derived exosomes are emerging as attractive options to improve the efficacy and...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Fahimeh Lavi Arab Akram Hoseinzadeh Fatemeh Hafizi Fatemeh Sadat Mohammadi Farid Zeynali Melika Hadad Tehran Amirreza Rostami Source Type: research
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice
In this study, we initially confirmed that chronic ethanol exposure (CEE) induces anxiety-like behaviors in mice through open field test and elevated plus maze test. The cGAS/STING signaling pathway has been confirmed to exhibits a significant association with inflammatory signaling responses in both peripheral and central systems. Western blot analysis confirmed alterations in the cGAS/STING signaling pathway during CEE, including the upregulation of p-TBK1 and p-IRF3 proteins. Moreover, we observed microglial activation in the prefrontal cortex (PFC) of CEE mice, characterized by significant alterations in branching morp...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Wei Zhao Shuang Zhao Ran Wei Ziqi Wang Fang Zhang Fangjiao Zong Han-Ting Zhang Source Type: research
Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis
CONCLUSION: These findings provide new strategies and potential targets for preventing and treating NAFLD. NOS2, PTGS2, ALB, and IL6 may serve as biomarkers for ADAR1 deletion-related NAFLD, which could help for developing its new diagnostic and therapeutic strategies.PMID:38696908 | DOI:10.1016/j.intimp.2024.112177 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 2, 2024 Category: Allergy & Immunology Authors: Xuecui Yin Yang Mi Xiaohan Wang Ya Li Xiaohui Zhu Ihtisham Bukhari Qingde Wang Pengyuan Zheng Xia Xue Youcai Tang Source Type: research
A comprehensive review of miR-21 in liver disease: Big impact of little things
Int Immunopharmacol. 2024 May 1;134:112116. doi: 10.1016/j.intimp.2024.112116. Online ahead of print.ABSTRACTmicroRNAs (miRNAs), a class of non-coding RNA with 20-24 nucleotides, are defined as the powerful regulators for gene expression. miR-21 is a multifunctional miRNA enriched in the circulatory system and multiple organs, which not only serves as a non-invasive biomarker in disease diagnosis, but also participates in many cellular activities. In various chronic liver diseases, the increase of miR-21 affects glycolipid metabolism, viral infection, inflammatory and immune cell activation, hepatic stellate cells activati...
Source: International Immunopharmacology - May 2, 2024 Category: Allergy & Immunology Authors: Xinyan Xue Yanzhi Li Yuxin Yao Shenglin Zhang Cheng Peng Yunxia Li Source Type: research
Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway
CONCLUSION: ARP could alleviate IBD-induced colon damage and associated depressive-like behaviors mainly via suppressing inflammatory cytokines activity, serum LPS concentration, and affecting the NF-κB/kynurenine pathway.PMID:38691917 | DOI:10.1016/j.intimp.2024.112158 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Afrooz Mohammadgholi-Beiki Mohammad Sheibani Majid Jafari-Sabet Manijeh Motevalian Parvaneh Rahimi-Moghaddam Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
Comprehensive quantifications of tumour microenvironment to predict the responsiveness to immunotherapy and prognosis for paediatric neuroblastomas
In this study, the TMEs of neuroblastoma were grouped by their genetic signatures into four distinct subtypes: immune enriched, immune desert, non-proliferative and fibrotic. An Immune Score and a Proliferation Score were constructed based on the molecular features of the subtypes to quantify the immune microenvironment or malignancy degree of cancer cells in neuroblastoma, respectively. The Immune Score correlated with a patient's response to immunotherapy; the Proliferation Score was an independent prognostic biomarker for neuroblastoma and proved to be more accurate than the existing clinical predictors. This double sco...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Mingkun Song Yiming Sun Yikai Hu Chong Wang Yan Jin Yun Liu Yurong Da Qiang Zhao Rongxiu Zheng Long Li Source Type: research
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation
Int Immunopharmacol. 2024 Apr 30;134:112143. doi: 10.1016/j.intimp.2024.112143. Online ahead of print.ABSTRACTChronic inflammation is a significant contributor to hypertensive heart failure. Carnosol (Car), primarily derived from the sage plant (Salvia carnosa), exhibits anti-inflammatory properties in a range of systems. Nevertheless, the influence of angiotensin II (Ang II) on cardiac remodeling remains uncharted. Car was shown to protect mice's hearts against Ang II-induced heart damage at dosages of 20 and 40 mg/kg/d. This protection was evident in a concentration-related decrease in the remodeling of the heart and dys...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Diyun Xu Bozhi Ye Liming Lin Yanhong Jin Yuchen Jiang Zhaozheng Zheng Yanghao Chen Xue Han Wei Wang Gaojun Wu Zaishou Zhuang Peiren Shan Guang Liang Source Type: research
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling
Int Immunopharmacol. 2024 Apr 30;134:112165. doi: 10.1016/j.intimp.2024.112165. Online ahead of print.ABSTRACTParticulate matter (PM) is considered the fundamental component of atmospheric pollutants and is associated with the pathogenesis of many respiratory diseases. Fibroblast growth factor 10 (FGF10) mediates mesenchymal-epithelial signaling and has been linked with the repair process of PM-induced lung injury (PMLI). However, the pathogenic mechanism of PMLI and the specific FGF10 protective mechanism against this injury are still undetermined. PM was administered in vivo into murine airways or in vitro to human bronc...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yao Qian Qiangqiang Shi Wanting Zhou Baiqi He Haibo Xu Bin Liu Wanqi Miao Saverio Bellusci Chengshui Chen Nian Dong Source Type: research
Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis
CONCLUSION: The present study revealed copper ionophores as a potential class of drugs for PitNET treatment. DSF induced PitNET cell death via cuproptosis and might be a promising option for PitNET therapy.PMID:38692018 | DOI:10.1016/j.intimp.2024.112159 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Ning Huang Yao Feng Yanting Liu Yong Zhang Li Liu Bo Zhang Tao Zhang Zhipeng Su Li Xue Zhe Bao Wu Source Type: research
Abnormal energy metabolism in the pathogenesis of systemic lupus erythematosus
Int Immunopharmacol. 2024 Apr 30;134:112149. doi: 10.1016/j.intimp.2024.112149. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a severe autoimmune disease with significant socioeconomic impact worldwide. Orderly energy metabolism is essential for normal immune function, and disordered energy metabolism is increasingly recognized as an important contributor to the pathogenesis of SLE. Disorders of energy metabolism are characterized by increased reactive oxygen species, ATP deficiency, and abnormal metabolic pathways. Oxygen and mitochondria are critical for the production of ATP, and both mitochondrial...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Shumei Cao Jiao Jiang Haoyuan Yin Lai Wang Qianjin Lu Source Type: research
Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway
CONCLUSION: ARP could alleviate IBD-induced colon damage and associated depressive-like behaviors mainly via suppressing inflammatory cytokines activity, serum LPS concentration, and affecting the NF-κB/kynurenine pathway.PMID:38691917 | DOI:10.1016/j.intimp.2024.112158 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Afrooz Mohammadgholi-Beiki Mohammad Sheibani Majid Jafari-Sabet Manijeh Motevalian Parvaneh Rahimi-Moghaddam Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
