Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway

CONCLUSION: ARP could alleviate IBD-induced colon damage and associated depressive-like behaviors mainly via suppressing inflammatory cytokines activity, serum LPS concentration, and affecting the NF-κB/kynurenine pathway.PMID:38691917 | DOI:10.1016/j.intimp.2024.112158

Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Afrooz Mohammadgholi-Beiki Mohammad Sheibani Majid Jafari-Sabet Manijeh Motevalian Parvaneh Rahimi-Moghaddam Source Type: research