European Journal of Pharmaceutics and Biopharmaceutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Dual targeting total saponins of Pulsatilla of natural polymer crosslinked gel beads with multiple therapeutic effects for ulcerative colitis treatment
In conclusion, our gel bead is a promising approach for the treatment of UC and significant for the researches on the pathogenesis and treatment mechanism of UC.PMID:38704102 | DOI:10.1016/j.ejpb.2024.114309 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 4, 2024 Category: Drugs & Pharmacology Authors: Min-Quan Zhang Liang-Hui Huang Min-Cheng Gong Wei-Man Hong Rong Xie Jin Wang Liang-Liang Zhou Zhen-Hua Chen Source Type: research
Priming with oncolytic adenovirus followed by anti-PD-1 and paclitaxel treatment leads to improved anti-cancer efficacy in the 3D TNBC model
Eur J Pharm Biopharm. 2024 Apr 30:114300. doi: 10.1016/j.ejpb.2024.114300. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is considered one of the most incurable malignancies due to its clinical characteristics, including high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Therefore, it remains a critical unmet medical need. On the other hand, poor delivery efficiency continues to reduce the efficacy of anti-cancer therapeutics developed against solid tumours using various strategies, such as genetically engineered oncolytic vectors used as nanocarriers. The study was...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 2, 2024 Category: Drugs & Pharmacology Authors: Lukasz Kuryk Sara Mathlouthi Magdalena Wieczorek Beata Gad Beate Rinner Alessio Malfanti Francesca Mastrotto Stefano Salmaso Paolo Caliceti Mariangela Garofalo Source Type: research
Priming with oncolytic adenovirus followed by anti-PD-1 and paclitaxel treatment leads to improved anti-cancer efficacy in the 3D TNBC model
Eur J Pharm Biopharm. 2024 Apr 30:114300. doi: 10.1016/j.ejpb.2024.114300. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is considered one of the most incurable malignancies due to its clinical characteristics, including high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Therefore, it remains a critical unmet medical need. On the other hand, poor delivery efficiency continues to reduce the efficacy of anti-cancer therapeutics developed against solid tumours using various strategies, such as genetically engineered oncolytic vectors used as nanocarriers. The study was...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 2, 2024 Category: Drugs & Pharmacology Authors: Lukasz Kuryk Sara Mathlouthi Magdalena Wieczorek Beata Gad Beate Rinner Alessio Malfanti Francesca Mastrotto Stefano Salmaso Paolo Caliceti Mariangela Garofalo Source Type: research
Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs
Eur J Pharm Biopharm. 2024 Apr 27:114305. doi: 10.1016/j.ejpb.2024.114305. Online ahead of print.ABSTRACTThe influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the ex vivo porcine ear model, which allowed to assess time and space resolved dermal penetration profiles of the AI. Fifteen different vehicles, including classical vehicles (hydrogel, oleogel, o/w cream, w/o ointment, amphiphilic cream) and innovative vehicles were included into the stud...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Vasudha Kaushik Wolfgang Schatton Cornelia M Keck Source Type: research
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Eur J Pharm Biopharm. 2024 Apr 27:114307. doi: 10.1016/j.ejpb.2024.114307. Online ahead of print.ABSTRACTHerein, we report the properties of nanostructured lipid carriers (NLCs) prepared with a gradient concentration of Bergenin (BGN) isolated from Pentaclethra macrophylla stem bark powder. A gradient concentration of BGN (BGN 0, 50, 100, 150, and 200 mg) was prepared in a 5 % lipid matrix consisting of Transcutol HP (75 %), Phospholipon 90H (15 %), and Gelucire 43/01 (10 %) to which a surfactant aqueous phase consisting of Tween 80, sorbitol, and sorbic acid was dissolved. The NLCs were evaluated by size, polydispersity i...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Petra Obioma Nnamani Chinekwu Nwagwu Edith Obioma Diovu Obiora Emmanuel Abonyi Mariia Nesterkina Tobias Neu Cl émentine Richter Brigitta Loretz Claus-Michael Lehr Source Type: research
Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Eur J Pharm Biopharm. 2024 Apr 28:114308. doi: 10.1016/j.ejpb.2024.114308. Online ahead of print.ABSTRACTWe have previously developed an in vitro instrument, termed subcutaneous injection site simulator (SCISSOR), that can be used to monitor release properties of an active pharmaceutical ingredient (API) and formulation components of a medicine designed for SC injection. Initial studies to validate the SCISSOR instrument applications used a simple hyaluronic acid (HA) hydrogel to monitor early release events. We now report a type of cross-linked HA that can, when combined with HA, provide a hydrogel (HA-XR) with optical cl...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Conor Gomes Kate Gridley Imogen Anastasiou B álint Sinkó Randall J Mrsny Source Type: research
Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs
Eur J Pharm Biopharm. 2024 Apr 27:114305. doi: 10.1016/j.ejpb.2024.114305. Online ahead of print.ABSTRACTThe influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the ex vivo porcine ear model, which allowed to assess time and space resolved dermal penetration profiles of the AI. Fifteen different vehicles, including classical vehicles (hydrogel, oleogel, o/w cream, w/o ointment, amphiphilic cream) and innovative vehicles were included into the stud...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Vasudha Kaushik Wolfgang Schatton Cornelia M Keck Source Type: research
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Eur J Pharm Biopharm. 2024 Apr 27:114307. doi: 10.1016/j.ejpb.2024.114307. Online ahead of print.ABSTRACTHerein, we report the properties of nanostructured lipid carriers (NLCs) prepared with a gradient concentration of Bergenin (BGN) isolated from Pentaclethra macrophylla stem bark powder. A gradient concentration of BGN (BGN 0, 50, 100, 150, and 200 mg) was prepared in a 5 % lipid matrix consisting of Transcutol HP (75 %), Phospholipon 90H (15 %), and Gelucire 43/01 (10 %) to which a surfactant aqueous phase consisting of Tween 80, sorbitol, and sorbic acid was dissolved. The NLCs were evaluated by size, polydispersity i...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Petra Obioma Nnamani Chinekwu Nwagwu Edith Obioma Diovu Obiora Emmanuel Abonyi Mariia Nesterkina Tobias Neu Cl émentine Richter Brigitta Loretz Claus-Michael Lehr Source Type: research
Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Eur J Pharm Biopharm. 2024 Apr 28:114308. doi: 10.1016/j.ejpb.2024.114308. Online ahead of print.ABSTRACTWe have previously developed an in vitro instrument, termed subcutaneous injection site simulator (SCISSOR), that can be used to monitor release properties of an active pharmaceutical ingredient (API) and formulation components of a medicine designed for SC injection. Initial studies to validate the SCISSOR instrument applications used a simple hyaluronic acid (HA) hydrogel to monitor early release events. We now report a type of cross-linked HA that can, when combined with HA, provide a hydrogel (HA-XR) with optical cl...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Conor Gomes Kate Gridley Imogen Anastasiou B álint Sinkó Randall J Mrsny Source Type: research
Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs
Eur J Pharm Biopharm. 2024 Apr 27:114305. doi: 10.1016/j.ejpb.2024.114305. Online ahead of print.ABSTRACTThe influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the ex vivo porcine ear model, which allowed to assess time and space resolved dermal penetration profiles of the AI. Fifteen different vehicles, including classical vehicles (hydrogel, oleogel, o/w cream, w/o ointment, amphiphilic cream) and innovative vehicles were included into the stud...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Vasudha Kaushik Wolfgang Schatton Cornelia M Keck Source Type: research
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Eur J Pharm Biopharm. 2024 Apr 27:114307. doi: 10.1016/j.ejpb.2024.114307. Online ahead of print.ABSTRACTHerein, we report the properties of nanostructured lipid carriers (NLCs) prepared with a gradient concentration of Bergenin (BGN) isolated from Pentaclethra macrophylla stem bark powder. A gradient concentration of BGN (BGN 0, 50, 100, 150, and 200 mg) was prepared in a 5 % lipid matrix consisting of Transcutol HP (75 %), Phospholipon 90H (15 %), and Gelucire 43/01 (10 %) to which a surfactant aqueous phase consisting of Tween 80, sorbitol, and sorbic acid was dissolved. The NLCs were evaluated by size, polydispersity i...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Petra Obioma Nnamani Chinekwu Nwagwu Edith Obioma Diovu Obiora Emmanuel Abonyi Mariia Nesterkina Tobias Neu Cl émentine Richter Brigitta Loretz Claus-Michael Lehr Source Type: research
Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Eur J Pharm Biopharm. 2024 Apr 28:114308. doi: 10.1016/j.ejpb.2024.114308. Online ahead of print.ABSTRACTWe have previously developed an in vitro instrument, termed subcutaneous injection site simulator (SCISSOR), that can be used to monitor release properties of an active pharmaceutical ingredient (API) and formulation components of a medicine designed for SC injection. Initial studies to validate the SCISSOR instrument applications used a simple hyaluronic acid (HA) hydrogel to monitor early release events. We now report a type of cross-linked HA that can, when combined with HA, provide a hydrogel (HA-XR) with optical cl...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Conor Gomes Kate Gridley Imogen Anastasiou B álint Sinkó Randall J Mrsny Source Type: research
Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Eur J Pharm Biopharm. 2024 Apr 26:114306. doi: 10.1016/j.ejpb.2024.114306. Online ahead of print.ABSTRACTIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of B...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 28, 2024 Category: Drugs & Pharmacology Authors: Naianda Rezende Ribeiro Lucas Magno Oliveira Santos Scarleth Silva Costa Carolina Kei Myasaki Daniela Pagliara Lage Vivian Tamietti Martins Rory Cristiane Fortes De Brito Larissa Chaves Freire Ana Maria Ravena Severino Carvalho Bryan Victor Serafim Brigid Source Type: research
Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Eur J Pharm Biopharm. 2024 Apr 26:114306. doi: 10.1016/j.ejpb.2024.114306. Online ahead of print.ABSTRACTIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of B...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 28, 2024 Category: Drugs & Pharmacology Authors: Naianda Rezende Ribeiro Lucas Magno Oliveira Santos Scarleth Silva Costa Carolina Kei Myasaki Daniela Pagliara Lage Vivian Tamietti Martins Rory Cristiane Fortes De Brito Larissa Chaves Freire Ana Maria Ravena Severino Carvalho Bryan Victor Serafim Brigid Source Type: research
Development of a high throughput oxidation profiling strategy for monoclonal antibody products
Eur J Pharm Biopharm. 2024 Apr 25:114301. doi: 10.1016/j.ejpb.2024.114301. Online ahead of print.ABSTRACTOxidation is one of the most common degradation pathways of biopharmaceutics, potentially leading to altered product stability, pharmacokinetics, reduced biological activity and/or an increased immunogenicity. However, it is often insufficiently assessed in early development stages, leaving potential molecule liabilities undiscovered. Aim of the present work was the development of a high throughput oxidation profiling strategy, applicable throughout various stages of biopharmaceutical development. The study demonstrates...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 27, 2024 Category: Drugs & Pharmacology Authors: Paulina Fischer Olivia M Merkel Michael Siedlar Martin Huelsmeyer Source Type: research
