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Methylisothiazolinone-containing paint contributing to mucocutaneous and cutaneous symptoms: A case of aerosolized allergic contact dermatitis
Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are common preservatives present in personal, household, and industrial products including water-based paints. These agents have been recognized as significant contributors to what has been termed an “epidemic” of allergic contact dermatitis (ACD)1, 2. In fact, the 2019-2020 North American Contact Dermatitis Group report found that the MI patch test positivity rate (13.8%) was second only to nickel, with high clinical relevance2. The majority of MI reactions are secondary to direct contact e xposure and result in cutaneous-limited symptoms; however, a sma...
Source: Annals of Allergy, Asthma and Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Emma Roellke, Luz Fonacier, Erin Banta Tags: Letters Source Type: research

Navigating allergic disease in military accessions
In an era in which the readiness of a medically fit military force is more crucial than ever owing to escalating global tensions, the article by Adams et al1 emerges as a vital guide for allergists involved in the military medical evaluation process. The article provides a comprehensive review of this process, highlighting the unique challenges faced by allergists in assisting military applicants. Authored by military allergists with an “insider's” perspective, it provides an invaluable framework for civilian allergists nationwide, delving into the complexities of these evaluations with implications far beyond geograph...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Maureen Peterson, Theresa A. Bingemann Tags: Editorial Source Type: research

The kids are all right
Adgent et al1 analyzed the relationships (or lack thereof) between mothers ’ recall of experiencing potentially stressful situations during pregnancy and their contemporaneous report of asthma or wheezing in the child, in the Environmental Influences on Child Health Outcomes (ECHO) PATHWAYS cohorts. The study was not anchored by a single predefined hypothesis (the hypoth eses involved several different outcome measures), and only 1 of the 4 predefined outcomes (“current wheeze” but not “ever asthma,” “current asthma,” or “strict asthma”) was “significant” at the P (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Rebecca Tutino, Caroline Martinez, Aliza W. Pressman, Jaeah Chung, Eyal Shemesh Tags: Editorial Source Type: research

Go Tolerance!
Cartootorial: The anecdote of a college student who returns home for winter break to discover they are newly allergic to a childhood pet is so common that it has been dubbed the “Thanksgiving Effect.”1 However, the immunologic mechanism behind this loss of tolerance is poorly understood. One study recruited 97 college students for serial allergy testing upon arrival to college and again 8 months later.2 All students were tolerating a cat in the home prior to enrollment. During the study, none of the students became newly sensitized to cat. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Erin L. Reigh Tags: Marginal Zone Source Type: research

Decoding viral infections and risk for asthma
Respiratory syncytial virus (RSV) infections are the leading cause of pediatric hospitalizations and contribute significantly to morbidity and mortality. It is estimated that this virus causes 2.1 million outpatient (nonhospitalization) visits among children younger than 5 years old. Moreover, RSV is the likely pathogen in 75% to 80% of bronchiolitis cases,1 followed by rhinovirus, which accounts for 20% to 40% of cases.2 Approximately 30% of children with bronchiolitis have multiple viruses found at diagnosis. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Kirsten M. Kloepfer, Joshua L. Kennedy Tags: Editorial Source Type: research

Let us not conflate burn risk and race onto patients with atopic dermatitis
In this issue of the Annals of Allergy, Asthma& Immunology, Alexis et al1 evaluated the efficacy and safety of abrocitinib by race, ethnicity, and Fitzpatrick skin types (FST). This analysis included pooled data from 945 patients older than 12 years who received abrocitinib 200 mg, abrocitinib 100 mg, or placebo from 3 double-blind placebo-controlled atopic dermatitis (AD) trials.1 Race and ethnicity were self-reported. Only data from White (n = 628), Asian (n = 204), and Black (n = 83) patients were analyzed because of low numbers of other racial subgroups, including multiracial patients and those who did not self-report ...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Kanwaljit K. Brar Tags: Editorial Source Type: research

Primatene mist
I read with interest the article by Ho et al,1 “Cost-effectiveness of budesonide-formoterol vs inhaled epinephrine in US adults with mild asthma.” How interesting to see a cost analysis of using this over-the-counter (OTC) treatment compared with guidelines-based treatment! I agree with the authors that using OTC inhaled epinephrine is not e vidence-based and can be dangerous, even deadly.1,2 Current asthma guidelines suggest using bronchodilator only in conjunction with inhaled corticosteroid.3 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Deborah R. Liptzin Tags: Correspondence Source Type: research

Comment on geographic variation in disease burden among patients with severe persistent asthma in the United States
Asthma affects approximately 25 million individuals in the United States, approximately 20 million of whom are older than 18 years of age.1 These data have traditionally come from self-reporting of diagnosis through national datasets such as the National Health Interview Survey or the National Health and Nutrition Examination Survey. The national health policy for asthma management is often driven by a “one size fits all” approach on the basis of this national prevalence data, an approach that has significant shortcomings as it does not factor in state- and county-level heterogeneity with regard to asthma prevalence, s...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Rohit K. Katial, Flavia C.L. Hoyte Tags: Editorial Source Type: research

College-bound with allergies
For those who care for children, it is clear that “the days are long, but the years are short.”1 This fact is often brought into sharp relief when adolescents transition to college-bound young adults. Allergists-immunologists can follow an individual across their life span, and with a significant proportion of young adults impacted by allergic diseases, can play a significant role in the life transitions of our patients. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Marcus S. Shaker, Anna Nowak-Wegrzyn Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Source Type: research

The Age Specific Microbiome of Children with Milk, Egg, and Peanut Allergy
Immune regulation by gut microbiota is affected by dysbiosis and may precede food allergy onset. Prior studies lack comparisons stratified by age and clinical phenotype. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Punita Ponda, Jane E. Cerise, Brianne Navetta-Modrov, Jamie Kiehm, Grace M. Covelli, Jared Weiss, Annette T. Lee Tags: Original Article Source Type: research

Biomarkers and clinical outcomes after tezepelumab cessation: extended follow-up from the 2-year DESTINATION study
Long-term tezepelumab treatment in the DESTINATION study (NCT03706079) resulted in reduced asthma exacerbations, reduced biomarker levels and improved lung function and symptom control in patients with severe, uncontrolled asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Christopher E. Brightling, Marco Caminati, Jean-Pierre Llanos, Scott Caveney, Ales Kotalik, Janet M. Griffiths, Anna Lundahl, Elliot Israel, Ian D. Pavord, Michael E. Wechsler, Celeste Porsbjerg, Jonathan Corren, Monika Go łąbek, Neil Martin, Sandhia Po Source Type: research

Levels of Immunoglobulin E Sensitization Drive Symptom Thresholds in Allergic Rhinitis
CONCLUSION: With increasing number of sensitizations, AR patients experience an increased diversity of symptoms. Multimorbidity-related symptoms increase with sensitization rank, suggesting organ-specific thresholds.PMID:38679157 | DOI:10.1016/j.anai.2024.04.026 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 28, 2024 Category: Allergy & Immunology Authors: Maria V Dimou Paraskevi Xepapadaki John Lakoumentas Leonardos Mageiros Xenophon Aggelidis Maria Antonopoulou Petros Bakakos Sophia Βotskariova Konstantinos Chliveros Spyridon Chrysoulakis Dionysios Dimas Nikolaos Douladiris Mina Gaga Christos Grigoreas L Source Type: research