ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines
Biomed Res Int. 2023 Feb 6;2023:7891753. doi: 10.1155/2023/7891753. eCollection 2023.ABSTRACTThe inhibition of poly(ADP-ribose) polymerases (PARPs) and ataxia telangiectasia and Rad3-related (ATR) would be an alternative approach for cancer treatments. The aim of this study is to investigate the synergy of the different combinations of PARP inhibitors (olaparib, talazoparib, or veliparib) and ATR inhibitor AZD6738. A drug combinational synergy screen that combines olaparib, talazoparib, or veliparib with AZD6738 was performed to identify the synergistic interaction, and the combination index was calculated to verify synerg...
Source: Biomed Res - February 16, 2023 Category: Research Authors: Rakkreat Wikiniyadhanee Tassanee Lerksuthirat Wasana Stitchantrakul Sermsiri Chitphuk Shunichi Takeda Donniphat Dejsuphong Source Type: research
ATR Inhibitor Synergizes PARP Inhibitor Cytotoxicity in Homologous Recombination Repair Deficiency TK6 Cell Lines
Biomed Res Int. 2023 Feb 6;2023:7891753. doi: 10.1155/2023/7891753. eCollection 2023.ABSTRACTThe inhibition of poly(ADP-ribose) polymerases (PARPs) and ataxia telangiectasia and Rad3-related (ATR) would be an alternative approach for cancer treatments. The aim of this study is to investigate the synergy of the different combinations of PARP inhibitors (olaparib, talazoparib, or veliparib) and ATR inhibitor AZD6738. A drug combinational synergy screen that combines olaparib, talazoparib, or veliparib with AZD6738 was performed to identify the synergistic interaction, and the combination index was calculated to verify synerg...
Source: Biomed Res - February 16, 2023 Category: Research Authors: Rakkreat Wikiniyadhanee Tassanee Lerksuthirat Wasana Stitchantrakul Sermsiri Chitphuk Shunichi Takeda Donniphat Dejsuphong Source Type: research
Blood transcriptome and machine learning identified the crosstalk between COVID-19 and fibromyalgia: a preliminary study
CONCLUSIONS: Our study revealed the bridge role of immune dysregulation between COVID-19 and fibromyalgia, and screened underlying biomarkers to provide new clues for further clinical research.PMID:36762746 | DOI:10.55563/clinexprheumatol/tz9i6y (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 10, 2023 Category: Rheumatology Authors: Zhao Zhang Zhijie Zhu Dong Liu Zhenz Mi Huiren Tao Hongbin Fan Source Type: research
Silver-Russell syndrome and Turner syndrome in a girl with short stature treated with growth hormone - case report
CONCLUSIONS: The diagnosis of one genetic disorder does not rule out the possibility of a second genetic disease. Early diagnosis of coexistence of two different genetic syndromes, although very difficult, may help with quickly, appropriate therapy for patients and prevent them from developing serious complications.PMID:36734391 | DOI:10.5114/pedm.2022.121463 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - February 3, 2023 Category: Endocrinology Authors: Beata Wikiera Julita Noco ń-Bohusz Anna Noczy ńska Source Type: research
Silver-Russell syndrome and Turner syndrome in a girl with short stature treated with growth hormone - case report
CONCLUSIONS: The diagnosis of one genetic disorder does not rule out the possibility of a second genetic disease. Early diagnosis of coexistence of two different genetic syndromes, although very difficult, may help with quickly, appropriate therapy for patients and prevent them from developing serious complications.PMID:36734391 | DOI:10.5114/pedm.2022.121463 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - February 3, 2023 Category: Endocrinology Authors: Beata Wikiera Julita Noco ń-Bohusz Anna Noczy ńska Source Type: research
Silver-Russell syndrome and Turner syndrome in a girl with short stature treated with growth hormone - case report
CONCLUSIONS: The diagnosis of one genetic disorder does not rule out the possibility of a second genetic disease. Early diagnosis of coexistence of two different genetic syndromes, although very difficult, may help with quickly, appropriate therapy for patients and prevent them from developing serious complications.PMID:36734391 | DOI:10.5114/pedm.2022.121463 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - February 3, 2023 Category: Endocrinology Authors: Beata Wikiera Julita Noco ń-Bohusz Anna Noczy ńska Source Type: research
