SOX17 Allows Early Stage Colon Cancer to Evade the Immune System
Researchers here report on work that identifies SOX17 inhibition as a potential way to attack colon cancer in its early stages. Any successful cancer must have adopted one or more ways to suppress the immune system in order to grow past the earliest stages of a few cancerous cells. Interfering in those suppression mechanisms is a potential basis for therapy, as the researchers demonstrated here. Whether or not this line of work will make much further depends on whether an economically viable approach to SOX17 inhibition can be found, and whether or not it is a good target for many other forms of cancer. Colon canc...
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

How do we stop a resurgence of fascism?
Is it bad to write for hard-right outlets? There is no doubt that the Overton window has shifted to the right during the last decade or two.  It is now common to hear people saying things that, even in 2010 would have been thought to be frankly fascistic. I recall a conversation with the great biophysicist, Sir Bernard Katz, in 1992. He had come to UCL in 1936 to escape from the Nazi regime in Leipzig.  When I suggested to him that he must have been very pleased about the reunification of Germany, he pulled a long face and said “hmm, let’s wait to see what crawls out from under stones”.  ...
Source: DC's goodscience - March 11, 2024 Category: Science Authors: David Colquhoun Tags: Uncategorized Alan Sokal anti-vaccination antiscience Deborah Cohen fascism Margaret McCartney Paul Marshall Quillette sceptics skeptics Spiked Toby Young transgender UnHerd Source Type: blogs

The 7 Decade History of ChatGPT
By MIKE MAGEE Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.” This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs

What ’ s a link shortener, anyway?
I posted a survey about the likelihood of users clicking a charity or fundraising link that had been shortened with a tool like tinyURL, bit.ly or j.mp, or buff.ly. To my surprise, there was a comment from one follower telling me that he didn’t know what a link shortener was. Well, link shorteners are online tools that convert long website addresses, (URLs) into shorter, more manageable links. These shortened URLs redirect users to the original, longer URL when clicked. Many sites, like Amazon, Twitter, Wikipedia, and Youtube, have link shorteners to allow you to copy and share a shortened version of an internal link...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 6, 2024 Category: Science Authors: David Bradley Tags: Social Media Source Type: blogs

Religion and morality
A commenter asks about the relationship over time between religiosity, and crime and " sexual deviance. " You got it!If you will refer to my previous post on declining religiosity in America (or just take my word for it) the trend toward fewer people claiming religious affiliation began in about 1992. What a coinkydink! That ' s exactly when the crime rate began to decline. Here are property crimes (data is from the Bureau of Justice Statistics andI cribbed it from the Wikipedia article):  And whaddya know, that ' s also exactly when the homicide rate started to decline! (Note that it first started to go up sharp...
Source: Stayin' Alive - January 17, 2024 Category: American Health Source Type: blogs

How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future! Digital health should become an organic part of primary care in the future I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs

Non-invasive Transcranial Electrical Stimulation (TES) shows early promise to treat ADHD symptoms in children
While tDCS uses constant current intensity, tRNS and tACS use oscillating current. The vertical axis represents the current intensity in milliamp (mA), while the horizontal axis illustrates the time-course. Source: Wikipedia. Many children with ADHD benefit from medication treatment, behavioral treatment, or their combination, but others do not. In addition, parents are often reluctant to start their child on medication and high quality behavioral treatments are not readily accessible in many areas. The long-term efficacy of these treatments is also less than desirable. Thus, despite these evidence-based ADHD treatments, t...
Source: SharpBrains - September 19, 2023 Category: Neuroscience Authors: Dr. David Rabiner Tags: Attention & ADD/ADHD Technology & Innovation ADHD behavioral treatment ADHD medication treatment ADHD rating scale Cognitive-Training Cognitive-Training-Program Computerized-cognitive-training transcranial electrical stimulation Source Type: blogs

Dancing around the hexaflex: Using ACT in practice 4
Acceptance and commitment therapy (ACT) can be slippery to describe. It’s an approach that doesn’t aim to change thought content, but instead to help us shift the way we relate to what our mind tells us. It’s also an approach focused on workability: pragmatic and context-specific analysis of how well a strategy is working to achieve being able to do what matters. Over the next few posts I want to give some examples of how non-psychologists can use ACT in session (remember ACT is open for anyone to use it!). Willingess (Acceptance) – Choosing to experience it all Do you remember the poignancy of a beloved ...
Source: HealthSkills Weblog - September 10, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: ACT - Acceptance & Commitment Therapy Chronic pain Coping strategies Occupational therapy Physiotherapy Professional topics Psychology Science in practice acceptance and commitment therapy pain management Therapeutic approaches Source Type: blogs

Dancing around the hexaflex: Using ACT in practice  4
Acceptance and commitment therapy (ACT) can be slippery to describe. It’s an approach that doesn’t aim to change thought content, but instead to help us shift the way we relate to what our mind tells us. It’s also an approach focused on workability: pragmatic and context-specific analysis of how well a strategy is working to achieve being able to do what matters. Over the next few posts I want to give some examples of how non-psychologists can use ACT in session (remember ACT is open for anyone to use it!). Willingess (Acceptance) – Choosing to experience it all Do you remember the poignancy of a beloved ...
Source: HealthSkills Weblog - September 10, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: ACT - Acceptance & Commitment Therapy Chronic pain Coping strategies Occupational therapy Physiotherapy Professional topics Psychology Science in practice acceptance and commitment therapy pain management Therapeutic approaches Source Type: blogs

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

DNA Damage and Consequent Inflammation in Heart Failure
One of the ways in which cell damage characteristic of aging can provoke inflammation is via the mislocalization of DNA. Either nuclear DNA or mitochondrial DNA can find its way to the cytosol, where it can trigger responses evolved to detect bacterial or viral infection, or severe cell damage. This creates a cascade of downstream signaling leading to an inflammatory response. In youth these events occur comparatively rarely, and in circumstances wherein immune response and potentially even cell death are beneficial. With age, however, there is a continued mild but growing level of dysfunction and consequent sustained infl...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

How Cold Weather Affects Blood Pressure? New Study Reveals Surprising Facts
Conclusion In the vast tapestry of medical research, the recent study on seasonal trends in high blood pressure is a particularly illuminating thread. It’s shown us that something as seemingly benign as the changing of the seasons can impact a major health metric – our blood pressure. This isn’t just about statistics and numbers. It’s about lives. Recognizing and anticipating these patterns means healthcare providers can be better equipped to offer timely, effective care. And for those living with high blood pressure? It offers a roadmap. A guide to navigate the challenges of each season, with...
Source: The EMT Spot - September 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs

Study Courses Supercharge Anatomy & Physiology Success | TAPP 141
Get ready for a mind-bending 😲 rendezvous with Kevin Patton inEpisode 141, where he continues to spill the beans on histop-secret recipe for student triumph.  🏆 Brace yourself for this next adventure on his whirlwind tour of revolutionizing A&P 1 education, as we dissect the art of identifyingstudent pain points, personalizing preparation, and serving up the kind ofmentorship they ' ve been yearning for!0:00:00 | Introduction0:00:45 | One of Two Success Courses0:09:48 | Setting Up the Supplement Course0:18:44 | Structure of Class Sessions0:40:17 | Grading0:42:45 | Does an A&P Sup...
Source: The A and P Professor - August 17, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs

Why I ’ m not fazed by unremarkable results in therapy trials
Remember the old ‘pareto principle’? 80% of the results come from 20% of the input, or as Wikipedia informs me, “the principle of factor sparsity” I think we’ve got there with musculoskeletal pain, especially low back pain. The other ‘law’ that might apply is that of diminishing returns. We’ve learned a great deal about low back pain over my clinical career. We’ve essentially learned what not do to. In the name of progress, thousands of people have put their pain (their bodies) on the line. And progress has not exactly been great right? We’ve learned tha...
Source: HealthSkills Weblog - May 7, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Back pain Low back pain Occupational therapy Pain conditions Physiotherapy Professional topics Research Science in practice healthcare Therapeutic approaches Source Type: blogs

Analyzing the Consequences of Recent Youth Online Safety Proposals
Jennifer HuddlestonMany policymakers at both the state and federal levels have called for additional regulations to protect children ’s online privacy and improve online safety. While the desire to protect children is a well ‐​intentioned motivation, these proposals have significant consequences, and in many cases may even diminish children’s online privacy. In a new policy brief out today, I discuss the potential impact of these proposals for all internet users, not just children.In general, these proposed online safety regulations tend to fall into three major categories:A total or near total ban o...
Source: Cato-at-liberty - April 6, 2023 Category: American Health Authors: Jennifer Huddleston Source Type: blogs