Pathogenesis Analysis of Salivary Gland Tumors Through the Expression of Programmed Death-Ligand 1 (PD-L1)
This study was conducted to determine whether there is an immune escape through the expression of PD-L1 in salivary gland tumors. The tissue sections of PA, CXPA, a nd WT were stained with Hematoxylin Eosin and immunostained with a rabbit monoclonal recombinant anti-PD-L1 antibody. We observed immunopositive PD-L1 on the cell membrane with or without cytoplasm staining. PA and CXPA expressed PD-L1, accompanied by an anomaly expression of CXPA in several spots a t the salivary gland at the surgical border. Therefore, PD-L1 is one of the PA pathways to transform into CXPA through immune escape. WT expressed PD-L1 in the cyto...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - June 10, 2023 Category: ENT & OMF Source Type: research
Warthin Tumor of the Parotid Gland: The History of an Eponym
AbstractThe eponymous history of Warthin tumor (WT) is a fascinating issue in the field of salivary gland pathology. The late decades of the nineteenth century and the turn of the century saw notable German and French contributions on WT. Especially, the seminal 1910 paper of Albrecht and Arzt of Vienna is the foundation for the current knowledge of WT. It is generally believed that prior to this pioneering study, Hildebrand of G öttingen accurately described the lesion of WT in 1895. However, the historical origins of WT appear to be unsettled, and only a few German pathologists and surgeons are aware that dating back to...
Source: Head and Neck Pathology - May 25, 2023 Category: Pathology Source Type: research
Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018
ConclusionsWe consider both surgical techniques as valid. In our opinion, it is essential to study each case based on Quer ’s Classification to obtain the best surgical outcome. Based on a lower observed rate of complications such as facial nerve palsy, Frey’s syndrome, and bleeding, ECD seems to be the best option for the surgical treatment of Quer Class I lesions. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - May 16, 2023 Category: ENT & OMF Source Type: research
Correction: Value of T2-weighted-based radiomics model in distinguishing Warthin tumor from pleomorphic adenoma of the parotid
(Source: European Radiology)
Source: European Radiology - May 12, 2023 Category: Radiology Source Type: research
Histogram analysis of ultrasonographic images in the differentiation of benign and malignant parotid gland tumors
To evaluate the diagnostic value of histogram analysis (HA) using ultrasonographic (US) images for differentiation of pleomorphic adenoma (PA), adenolymphoma (AL), and malignant tumors (MT) in the parotid gland. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 30, 2023 Category: ENT & OMF Authors: Feifei Xia, Xiaoyu Zha, Wenjuan qin, Hui Wu, Zeying Li, Changxue Li Tags: Original Article Source Type: research
Differential diagnosis of parotid gland tumors using apparent diffusion coefficient, texture features, and their combination
CONCLUSION: The ADC value, texture features, and their combination demonstrated good diagnostic ability to distinguish between WTs and PAs. This method may be used to aid the differential diagnosis of parotid gland tumors, thereby promoting timely and adequate treatment.PMID:37015250 | DOI:10.1259/dmfr.20220404 (Source: Dentomaxillofacial Radiology)
Source: Dentomaxillofacial Radiology - April 4, 2023 Category: Radiology Authors: Hirotaka Muraoka Takashi Kaneda Takumi Kondo Shunya Okada Satoshi Tokunaga Source Type: research
Cancers, Vol. 15, Pages 1876: Support Tools in the Differential Diagnosis of Salivary Gland Tumors through Inflammatory Biomarkers and Radiomics Metrics: A Preliminary Study
Conclusions: Inflammatory biomarkers and radiomic features can comparably support a pre-surgical differential diagnosis. (Source: Cancers)
Source: Cancers - March 21, 2023 Category: Cancer & Oncology Authors: Umberto Committeri Simona Barone Giovanni Salzano Antonio Arena Gerardo Borriello Francesco Giovacchini Roberta Fusco Luigi Angelo Vaira Alfonso Scarpa Vincenzo Abbate Lorenzo Ugga Pasquale Piombino Franco Ionna Luigi Califano Giovanni Dell ’Aversana Or Tags: Article Source Type: research
Top Ten Oncocytic Head and Neck Lesions to Contemplate
ConclusionsCorrect diagnosis of oncocytic head and neck lesions requires a knowledge of the spectrum of possible entities, their characteristic sites of occurrence, architecture, histomorphology, and immunohistochemistry. Oncocytic subtypes of several newly described entities are now recognized. Both epithelial and non-epithelial mimics of oncocytes exist. The molecular features of oncocytic tumors can be helpful in their diagnosis and understanding their pathogenesis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
