Waldenstrom's Macroglobulinemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

EE534 Economic Burden of Waldenstr öm Macroglobulinemia, Marginal Zone Lymphoma and Chronic Lymphoid Leukemia
The aim of the analysis was to estimate the economic impact of three specific diseases: Waldenstr öm macroglobulinemia (WM), Marginal zone lymphoma (MZL) and chronic lymphocytic leukemia (CLL). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: M. Paoletti, P. Sciattella, A. Marcellusi, M. Scortichini, I. Ranieri, C. Bini, F.S. Mennini Source Type: research

EE227 Waldenstrom's Macroglobulinemia: An Overview of Treatment Patterns, Resource Use, and Costs From the Brazilian Private Healthcare Perspective
Waldenstrom's Macroglobulinemia (WM) is a rare and debilitating type of non-Hodgkin's lymphoma. Given the scarcity of local data, this study aimed to investigate treatment patterns, resource use and costs of WM, from the Brazilian private setting. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: M. Macedo, M. Resende, J. Genre, J. Martins, R.A. Fernandes, A.C. Pereira, A. Maiolino, S. Brasil, T. Carneiro, R. Tavares, S. Nabhan, G. Fleury-Perini Source Type: research

The performance and applied value of < sup > 18 < /sup > F-FDG PET/CT imaging in Waldenstrom macroglobulinemia
This study aimed to evaluate the metabolic status of WM by 18F-FDG PET/CT imaging. We retrospectively analyzed 20 patients who underwent pretherapy 18F-FDG PET-CT scan. All patients were diagnosed by bone marrow aspiration, laboratory examination and clinical symptoms. Bone marrow involvement was identified with 18F-FDG PET/CT imaging in 16 of 20, and the mean SUVmax of bone marrow was 4.06±0.85, Lymph nodes were involved in 8 of 20 patients, and the mean SUVmax of Lymph nodes was 4.07±1.27. Liver and spleen were involved in one case respectively, with SUVmax being 3.6 and 3.3. 1 case of extramedullary infiltration and 1...
Source: Molecular Medicine - November 29, 2023 Category: Molecular Biology Authors: Bo Pan Xingxing Zhu Qiang Xie Source Type: research

Broadening the horizon: potential applications of CAR-T cells beyond current indications
Engineering immune cells to treat hematological malignancies has been a major focus of research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several diseases can now be treated in highly therapy-refractory or relapsed conditions. Currently, a number of CD19- or BCMA-specific CAR-T-cell therapies are approved for acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), multiple myeloma (MM), and follicular lymphoma (FL). The implementation of these therapies has significantly improved patient outcome and survival even in cases with previously very poor ...
Source: Frontiers in Immunology - November 27, 2023 Category: Allergy & Immunology Source Type: research

Hematologic secondary malignancies among 102 Chinese patients with Waldenstrom ’s macroglobulinemia: a single-center case experience and literature review
Waldenstrom’s macroglobulinemia (WM) is a rare and indolent B-cell lymphoma. To investigate the type and survival of hematologic secondary malignancies (SMs) in Chinese patients with WM, we retrospectively reviewed the characteristics of 102 patients with WM from February 2002 to May 2023 in our center. Four men and two women were diagnosed with hematologic SMs. Of the six patients with hematologic SMs, one was diagnosed with acute myeloid leukemia (AML), one with multiple myeloma (MM), one with myelodysplastic syndrome (MDS), one with B-cell acute lymphoblastic leukemia (B-ALL), and two with diffuse large B-cell lymphom...
Source: Frontiers in Oncology - November 27, 2023 Category: Cancer & Oncology Source Type: research

Diffuse large B-cell lymphoma with continuously elevated immunoglobulin M following treatment: a case report with pathologic, immunophenotypic, and molecular analyses
This study will provide a panoramic understanding of the origin or biological characteristics of DLBCL co-occurring with WM. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - November 6, 2023 Category: Genetics & Stem Cells Source Type: research

Clonally related transformation from Waldenstr öm macroglobulinemia to diffuse large B-cell lymphoma with central nervous system involvement at diagnosis: a case report and literature review
AbstractHistological transformation to diffuse large B-cell lymphoma (DLBCL) rarely occurs in patients with Waldenstr öm macroglobulinemia (WM). The median time from WM diagnosis to DLBCL is 4–5 years. Extranodal involvement is common in transformed WM. However, central nervous system (CNS) involvement is relatively uncommon. Here, we report a case of a simultaneous diagnosis of WM and clonally related DLBCL, w ith the involvement of CNS demonstrated by dual enhancement in MRI. Nevertheless, it is unclear if CNS infiltration is caused by DLBCL or WM for the inaccessibility of brain biopsy. Intensified chemotherapy and ...
Source: Clinical and Experimental Medicine - November 3, 2023 Category: Research Source Type: research

95. Genomic profiling of a t(14;19) small B-cell lymphoma using whole exome sequencing
Small B-cell lymphomas are a diverse group of Non-Hodgkin lymphomas representing a clonal expansion of neoplastic B-cells. As molecular techniques evolve in clinical laboratories, this diverse group of tumors divides into more specific entities. Examples include MYD88 in lymphoplasmacytic lymphoma (LPL), t(14;18) in follicular lymphoma, and t(11;14) in mantle cell lymphoma. Less defined genetic changes include unusual translocations such as t(14;19), which has been reported in different subtypes of small B-cell lymphomas. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Shivaprasad Sathyanarayana, Joel Lefferts, Wahab Khan, Prabhjot Kaur, Jeremiah Karrs Source Type: research

New developments in the diagnosis and characterization of Waldenstr öm's macroglobulinemia
Expert Rev Hematol. 2023 Oct 31. doi: 10.1080/17474086.2023.2270779. Online ahead of print.ABSTRACTINTRODUCTION: Waldenström's macroglobulinemia (WM) is defined as a lymphoplasmacytic lymphoma (LPL) with immunoglobulin M (IgM) monoclonal gammopathy and morphologic evidence of bone marrow infiltration by lymphoplasmacytic lymphoma. Immunophenotyping and genotyping provide a firm pathological basis for diagnosis and are particularly valuable in differential diagnosis between WM and related diseases. Emerging technologies in mutational analysis present new opportunities, but challenges remain around standardization of method...
Source: Expert Review of Hematology - October 31, 2023 Category: Hematology Authors: Ram ón García-Sanz Zachary R Hunter Stephanie Poulain Marzia Varettoni Roger G Owen Source Type: research