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Advances in Treatment of Waldenstr öm Macroglobulinemia
AbstractPurpose of ReviewThe discovery of recurring somatic mutations, in particularMYD88 andCXCR4 mutations, in Waldenstr öm macroglobulinemia (WM), a rare B-cell lymphoproliferative disorder, led in the last decade to the development of several therapeutic agents with high efficacy. This review aims to provide an overview of available treatments in WM and novel agents, focusing on studies published over recent years.Recent FindingsThere is no international consensus on the best first-line option in treatment-na ïve patients. Randomized clinical trials are rare in WM and there has been no prospective comparison of chemo...
Source: Current Oncology Reports - October 19, 2023 Category: Cancer & Oncology Source Type: research

Screening for and diagnosis of monoclonal gammopathy
This article provides an overview on initial laboratory testing of monoclonal gammopathy to guide clinicians and laboratory professionals in the selection and interpretation of appropriate investigations. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 18, 2023 Category: Pathology Authors: Chong, Y. P., Lim, S. M., Loh, T. P., Mollee, P., Wijeratne, N., Choy, K. W. Tags: Best practice Source Type: research

Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective
We describe this interesting case in the context of its genomic findings and how it contributes to the literature as a whole. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - October 13, 2023 Category: Pathology Source Type: research

Hematological entities with plasmacytic differentiation: a case report
ConclusionsThis report describes the challenges of diagnosing IgM extramedullary plasmactyoma. Our case report highlights the importance of cytogenetics and NGS in establishing a correct diagnosis that indeed has prognostic and therapeutic implications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 26, 2023 Category: General Medicine Source Type: research

Oligosecretory Waldenstrom macroglobulinemia exhibits excellent treatment response and outcomes
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283402. Online ahead of print.ABSTRACTNot available.PMID:37706332 | DOI:10.3324/haematol.2023.283402 (Source: Haematologica)
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Wenjie Xiong Ying Yu Chunyan Sun Juan Du Zhen Cai Zanzan Wang Xinxin Cao Yuting Yan Jiawen Chen Yanshan Huang Zhongxing Jiang Huihan Wang Ting Niu Guangzhong Yang Hua Xue Bingzong Li Honghui Huang Zhenling Li Qinhua Liu Fei Li Ou Bai Min Mao Rong Fu Ling Source Type: research

Pleural effusion and Waldenstr öm macroglobulinemia: if cytology and flow cytometric findings do not match. A case report
We present a case report of a pleural localization of Waldenström macroglobulinaemia detected by flow cytometry.PMID:37700705 | DOI:10.4081/monaldi.2023.2665 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - September 13, 2023 Category: Respiratory Medicine Authors: Emanuele Stirpe Floriana Bardaro Johanna K öhl Source Type: research