Transcriptional variations at perilesional site in vitiligo patients: probably a fight for cell-survival
Arch Dermatol Res. 2024 Apr 25;316(5):134. doi: 10.1007/s00403-024-02854-z.ABSTRACTExploration of gene expression variations is a potential source to unravel biological pathways involved in pathological changes in body and understand the mechanism underneath. Vitiligo patients were explored for gene expression changes transcriptionally at perilesional site in comparison to normal site of same patients for melanogenesis pathway (TYR, DCT & TYRP1) cell adhesion (MMPs & TIMP1), cell survival (BCL2 & BAX1) as well as proliferation, migration & development (SOX9, SOX10 & MITF) regulatory system, using skin b...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Sushma Tanwar Davinder Parsad Source Type: research
Transcriptional variations at perilesional site in vitiligo patients: probably a fight for cell-survival
AbstractExploration of gene expression variations is a potential source to unravel biological pathways involved in pathological changes in body and understand the mechanism underneath. Vitiligo patients were explored for gene expression changes transcriptionally at perilesional site in comparison to normal site of same patients for melanogenesis pathway (TYR, DCT& TYRP1) cell adhesion (MMPs& TIMP1), cell survival (BCL2& BAX1) as well as proliferation, migration& development (SOX9, SOX10& MITF) regulatory system, using skin biopsy samples. Results were also compared with changes in gene expression for me...
Source: Archives of Dermatological Research - April 25, 2024 Category: Dermatology Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Use of complementary and alternative medicine in vitiligo: a cross-sectional survey
AbstractVitiligo is characterized by skin depigmentation, which can lead to profound psychological effects and decreased quality of life, especially for those with skin of color. Individuals with vitiligo may utilize complementary and alternative medicine (CAM) due to limited treatment options with varying efficacy.An anonymous, multiple-choice, cross-sectional questionnaire was distributed to participants with vitiligo in the United States through online forums. Data on disease characteristics, use of prescription medications, use of topical therapies, supplements, and diets, and perceptions of CAM were collected.In total...
Source: Archives of Dermatological Research - April 23, 2024 Category: Dermatology Source Type: research
'Substantial clinical benefit' and 'substantial clinical worsening' cut-off of Vitiligo Impact Scale (VIS)-22 change scores
Br J Dermatol. 2024 Apr 22:ljae178. doi: 10.1093/bjd/ljae178. Online ahead of print.NO ABSTRACTPMID:38644793 | DOI:10.1093/bjd/ljae178 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 22, 2024 Category: Dermatology Authors: Vishal Gupta Neha Taneja Hem Chandra Sati Vishnubhatla Sreenivas M Ramam Source Type: research
'Substantial clinical benefit' and 'substantial clinical worsening' cut-off of Vitiligo Impact Scale (VIS)-22 change scores
Br J Dermatol. 2024 Apr 22:ljae178. doi: 10.1093/bjd/ljae178. Online ahead of print.NO ABSTRACTPMID:38644793 | DOI:10.1093/bjd/ljae178 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 22, 2024 Category: Dermatology Authors: Vishal Gupta Neha Taneja Hem Chandra Sati Vishnubhatla Sreenivas M Ramam Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Protocol for a systematic review and meta-analysis on Janus kinase inhibitors in the management of vitiligo
DiscussionThe proposed systematic review and meta-analysis describe the methods for summarizing and synthesizing the evidence on the effectiveness and patient-centered outcomes concerning the treatment of vitiligo with JAK inhibitors that were recently approved for this indication. To disseminate further the results of our systematic review, we plan to present them at international conferences and meetings. Our findings will provide robust evidence to facilitate decision-making at the policy or practitioner level.Systematic review registrationPROSPERO CRD42023383920. (Source: Systematic Reviews)
Source: Systematic Reviews - April 19, 2024 Category: International Medicine & Public Health Source Type: research
IL-12/IL-23 independent function of Batf3-dependent dendritic cells is required for initiation of disease in a mouse model of vitiligo
Vitiligo is an IFN- ɣ-dependent autoimmune skin disease that causes depigmentation, and we used a mouse model of vitiligo to investigate the role of the Batf3 transcription factor in disease. Batf3 is required for the survival of a small subset of dendritic cells (DCs) known as type 1 classical DCs (cDC1) (identifiabl e in mice by CD103 and CD8a expression), which are primarily found within epithelial tissues and associated lymph nodes where they provide crucial contributions to pathogen defense, tumor surveillance, and peripheral inflammation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Michael L. Frisoli, Jillian M. Richmond, John E. Harris Tags: Letters to the Editor Source Type: research
IL-12/IL-23 –Independent Function of BATF3-Dependent Dendritic Cells Is Required for Initiation of Disease in a Mouse Model of Vitiligo
Vitiligo is an IFN- ɣ–dependent autoimmune skin disease that causes depigmentation, and we used a mouse model of vitiligo to investigate the role of the BATF3 transcription factor in disease. BATF3 is required for the survival of a small subset of dendritic cells (DCs) known as type 1 classical DCs (identifiable in mice by CD103 and CD8a expression), which are primarily found within epithelial tissues and associated lymph nodes where they provide crucial contributions to pathogen defense, tumor surveillance, and peripheral inflammation (Supplementary Figure S1). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Michael L. Frisoli, Jillian M. Richmond, John E. Harris Tags: Letters to the Editor Source Type: research
Use of a large patient database to analyze disease burden and treatment patterns among patients with vitiligo
Br J Dermatol. 2024 Apr 16:ljae166. doi: 10.1093/bjd/ljae166. Online ahead of print.NO ABSTRACTPMID:38623690 | DOI:10.1093/bjd/ljae166 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 16, 2024 Category: Dermatology Authors: Valeria Brazzelli Andrea Michelerio Source Type: research
