Human Mesenchymal Stem Cell-Derived Exosomes Promote the Proliferation and Melanogenesis of Primary Melanocytes by Attenuating the H < sub > 2 < /sub > O < sub > 2 < /sub > -Related Cytotoxicity in vitro
CONCLUSION: Our findings indicate that treatment with a low dose of MSC-Exo promotes the proliferation and melanogenesis of human primary melanocytes by ameliorating the H2O2-induced apoptosis and senescence of melanocytes. MSC-Exo may be a promising therapeutic strategy of vitiligo.PMID:38524392 | PMC:PMC10959324 | DOI:10.2147/CCID.S446676 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 25, 2024 Category: Dermatology Authors: Yexiao Wang Zibin He Bingqin Luo Hioteng Wong Liangcai Wu Hui Zhou Source Type: research
Risk Factors for Lichen Sclerosus: A Case-Control Study of 43,000 Finnish Women
CONCLUSIONS: Certain autoimmune diseases and urinary incontinence were associated with LS.PMID:38518214 | DOI:10.1097/LGT.0000000000000796 (Source: Cancer Control)
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Pia Halonen Oskari Heikinheimo Kishor Hadkhale Mika Gissler Eero Pukkala Maija Jakobsson Source Type: research
A pledge for a better care and consideration of patients with vitiligo
Br J Dermatol. 2024 Mar 21:ljae083. doi: 10.1093/bjd/ljae083. Online ahead of print.NO ABSTRACTPMID:38513637 | DOI:10.1093/bjd/ljae083 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 21, 2024 Category: Dermatology Authors: Thierry Passeron Source Type: research
A pledge for a better care and consideration of patients with vitiligo
Br J Dermatol. 2024 Mar 21:ljae083. doi: 10.1093/bjd/ljae083. Online ahead of print.NO ABSTRACTPMID:38513637 | DOI:10.1093/bjd/ljae083 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 21, 2024 Category: Dermatology Authors: Thierry Passeron Source Type: research
A turn-on fluorescence probe for imaging tyrosinase at the wound site in broken tail of zebrafish
Bioorg Chem. 2024 Mar 18;146:107298. doi: 10.1016/j.bioorg.2024.107298. Online ahead of print.ABSTRACTTyrosinase (TYR) is a copper-containing oxidase that affects the synthesis of melanin in the human body, which is regulate to the pigmentation of the skin. Nevertheless, abnormal expression of TYR can lead to albinism, vitiligo and other skin diseases. Excessive accumulation of TYR is a marker of melanoma cancer and an important factor leading to pigmentation during wound healing, freckles and browning of fruits and vegetables. Efficient tracking of TYR is of significance for studying its pathophysiological mechanism. Here...
Source: Bioorganic Chemistry - March 19, 2024 Category: Chemistry Authors: Dingguo Chen Yuan Ji Shiran Sun Shouzhi Pu Source Type: research
A turn-on fluorescence probe for imaging tyrosinase at the wound site in broken tail of zebrafish
Bioorg Chem. 2024 Mar 18;146:107298. doi: 10.1016/j.bioorg.2024.107298. Online ahead of print.ABSTRACTTyrosinase (TYR) is a copper-containing oxidase that affects the synthesis of melanin in the human body, which is regulate to the pigmentation of the skin. Nevertheless, abnormal expression of TYR can lead to albinism, vitiligo and other skin diseases. Excessive accumulation of TYR is a marker of melanoma cancer and an important factor leading to pigmentation during wound healing, freckles and browning of fruits and vegetables. Efficient tracking of TYR is of significance for studying its pathophysiological mechanism. Here...
Source: Bioorganic Chemistry - March 19, 2024 Category: Chemistry Authors: Dingguo Chen Yuan Ji Shiran Sun Shouzhi Pu Source Type: research
Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star
Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo. (Source: Jou...
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Yue Wu, Yiwen Yang, Yi Lin, Yuecen Ding, Ziqi Liu, Leihong Xiang, Mauro Picardo, Chengfeng Zhang Tags: Review Source Type: research
Exploring Therapeutic Approaches for Vitiligo: An Inclusive Review from Translational Modalities to Alternative Therapies
AbstractPurpose of ReviewThe primary objective of this extensive literature review was to explore emerging therapeutic modalities for Vitiligo, with the aim of identifying promising avenues for treatment. These modalities encompass various techniques such as melanocyte transplantation for repopulation and innovative pharmacological interventions aimed at modulating immune responses. This review aims to shed light on the theories underlying Vitiligo pathogenesis and evaluate the efficacy of a range of therapeutic interventions and preventive measures associated with the condition.Recent FindingsCutting-edge research in the ...
Source: Current Dermatology Reports - March 14, 2024 Category: Dermatology Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662993.ABSTRACTTebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the pos...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Lauren M Fahmy Celine M Schreidah Diana E McDonnell Richard D Carvajal Cynthia M Magro Larisa J Geskin Source Type: research
