Vitiligo: advances in pathophysiology research and treatment development
Trends Mol Med. 2024 May 4:S1471-4914(24)00097-2. doi: 10.1016/j.molmed.2024.04.009. Online ahead of print.ABSTRACTThe autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including re...
Source: Molecular Medicine - May 5, 2024 Category: Molecular Biology Authors: Zhussipbek Mukhatayev I Caroline Le Poole Source Type: research
Vitiligo: advances in pathophysiology research and treatment development
Trends Mol Med. 2024 May 4:S1471-4914(24)00097-2. doi: 10.1016/j.molmed.2024.04.009. Online ahead of print.ABSTRACTThe autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including re...
Source: Trends in Molecular Medicine - May 5, 2024 Category: Molecular Biology Authors: Zhussipbek Mukhatayev I Caroline Le Poole Source Type: research
Vitiligo: advances in pathophysiology research and treatment development
Trends Mol Med. 2024 May 4:S1471-4914(24)00097-2. doi: 10.1016/j.molmed.2024.04.009. Online ahead of print.ABSTRACTThe autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including re...
Source: Molecular Medicine - May 5, 2024 Category: Molecular Biology Authors: Zhussipbek Mukhatayev I Caroline Le Poole Source Type: research
Vitiligo: advances in pathophysiology research and treatment development
Trends Mol Med. 2024 May 4:S1471-4914(24)00097-2. doi: 10.1016/j.molmed.2024.04.009. Online ahead of print.ABSTRACTThe autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including re...
Source: Trends in Molecular Medicine - May 5, 2024 Category: Molecular Biology Authors: Zhussipbek Mukhatayev I Caroline Le Poole Source Type: research
Vitiligo: advances in pathophysiology research and treatment development
Trends Mol Med. 2024 May 4:S1471-4914(24)00097-2. doi: 10.1016/j.molmed.2024.04.009. Online ahead of print.ABSTRACTThe autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including re...
Source: Trends in Molecular Medicine - May 5, 2024 Category: Molecular Biology Authors: Zhussipbek Mukhatayev I Caroline Le Poole Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
