Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star

Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo.

Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Yue Wu, Yiwen Yang, Yi Lin, Yuecen Ding, Ziqi Liu, Leihong Xiang, Mauro Picardo, Chengfeng Zhang Tags: Review Source Type: research