Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Empowering Biomedical Research in Rural West Virginia
Public health crises often disproportionately impact rural America. Sally L. Hodder, M.D., works to alleviate these disparities, especially regarding the opioid crisis and the COVID-19 pandemic. She’s the director of the West Virginia Clinical and Translational Science Institute (WVCTSI), the associate vice president of clinical and translational research, and a professor of medicine at West Virginia University.
Dr. Sally Hodder. Credit: West Virginia University.
Dr. Hodder’s work is focused in West Virginia, but her results are valuable assets to researchers across the country. Not only does treating chronic...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 23, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness COVID-19 Medicines Pain Source Type: blogs
America, the intolerant
BY ANISH KOKA
Historically, the great tension between liberty and authority was between government as embodied by the ruling class and its subjects. Marauding barbarians and warring city-states meant that society endowed a particular class within society with great powers to protect the weaker members of society. It was quickly recognized that the ruling class could use these powers for its own benefit on the very people it was meant to protect, and so society moved to preserve individual liberties first by recognizing certain rights that rulers dare not breach lest they risk rebellion. The natural nex...
Source: The Health Care Blog - November 23, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Anish Koka COVID-19 in-hospital death Source Type: blogs
The Realization that Developing Rejuvenation Therapies is the Most Useful Thing One Can Do with Great Wealth
A core point regarding wealth, realized by many but only acted on by a few to date, is that being the wealthiest individual in the graveyard begins to look very foolish in an era in which research and development is producing the basis for rejuvenation therapies. Historically, people traded time for wealth. Now, we enter the start of the era in which people can trade wealth for time. Fortunately, this is a collaborative venture: no-one wins on their own. Either sufficient funding is devoted to the right projects in rejuvenation biotechnology, and all humanity benefits as a result, or we as a society collectively fail to ac...
Source: Fight Aging! - November 22, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Why HIV and COVID-19 vaccine screening should go together
During the COVID-19 pandemic, Americans got accustomed to regularly answering a series of questions about our risk of exposure to COVID and our possible symptoms. For more than two years, our country remained laser-focused on this protection, demonstrating our health care system’s ability to mount a strong response to a public health crisis. So why
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Why HIV and COVID-19 vaccine screening should go together originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 22, 2022 Category: General Medicine Authors: Maranda C. Ward, EdD, MPH Tags: Conditions Infectious Disease Primary Care Source Type: blogs
Lowering Drug Costs and Prices by Expanding Access to Biosimilars
Jeffrey A. SingerToday Senator Mike Lee (R ‑UT) introduced theBiosimilar Red Tape Elimination Act. Thebill seeks to reduce health care costs by streamlining the Food and Drug Administration ’s process to approve biosimilar drug products. It does this by prohibiting the FDA from requiring biosimilar drugs to undergo “switching studies” before the agency approves them as interchangeable with the original biological medicine.Unlike conventional medicines, which drug companies chemically synthesize to a specific molecular structure, biological medicines have natural sources, are complex, and may contain combinatio...
Source: Cato-at-liberty - November 18, 2022 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
The Debate on Protecting Intellectual Property Rights for COVID-19 Vaccines & Therapeutics
Brian Zupruk (Independent), The Debate on Protecting Intellectual Property Rights for COVID-19 Vaccines& Therapeutics (2022): COVID-19 is proving a durable obstacle to global public health and to the world ’s economies. And while the battle against COVID has largely been... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - November 18, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Preparing for fall and winter: Importance of COVID-19 vaccination during the flu season [PODCAST]
This article is sponsored by Novavax. In this special sponsored episode. I’m joined by Dr. Filip Dubovsky, chief medical officer at Novavax, to discuss topics like COVID-19 and influenza in the fall and winter seasons, the importance of education to understand your vaccine options while given the freedom to make that choice, navigating misinformation, and
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Preparing for fall and winter: Importance of COVID-19 vaccination during the flu season [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 16, 2022 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Sponsored COVID Infectious Disease Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 954: Speculating sarbecovirus spillovers with Michael Letko
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. (Source: virology blog)
Source: virology blog - November 13, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ACE2 cell entry coronavirus COVID-19 Khosta virus pandemic RBD sarbecovirus SARS-CoV-2 Tmprss2 trypsin viral viruses Source Type: blogs
TWiV 953: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19, protection against Omicron from vaccination and […] (Source: virology blog)
Source: virology blog - November 12, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid marburg virus monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 953: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19, protection against Omicron from vaccination and … TWiV 953: Clinical update with Dr. Daniel Griffin Read More » (Source: virology blog)
Source: virology blog - November 12, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid marburg virus monkeypox monoclonal antibody Omicron pandemic poliovirus SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Senescent Cells as a Cancer Vaccine
Researchers here note the discovery that vaccinating mice with senescent cancer cells ensures that the immune system will more aggressively attack a later introduction of cancerous cells. Since we know that most cancer therapies induce senescence in cancerous cells to a fair degree, one has to think that the effectiveness of this approach will diminish as a cancer progresses to form a solid tumor and co-opts the immune system in various ways. Still, it sounds as though it could be a potentially useful after, for example, surgical resection of a tumor, to help reduce the odds that the cancer will reoccur.
Scientis...
Source: Fight Aging! - November 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Legal Character and Practical Implementation of a TRIPS Waiver for COVID-19 Vaccines
Andrew D. Mitchell (Monash University), Antony Scott Taubman (University of Melbourne), The Legal Character and Practical Implementation of a TRIPS Waiver for COVID-19 Vaccines, Fordham Intell. Prop. Media& Ent. L.J.(Forthcoming): Almost two years after initial proposals for a COVID-19... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - November 7, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
