The Case Against Race-Based Quotas in Pharmaceutical Trials
Michael Conklin (Angelo State University), The Case Against Race-Based Quotas in Pharmaceutical Trials (2022): In 2020, while over 5,000 people worldwide were dying from COVID-19 every day, Moderna intentionally slowed down enrollment of its vaccine clinical trial to focus on... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 6, 2023 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Lost Opportunities to Contain COVID-19 in China
Three years after the SARS-COV-2 virus emerged in Wuhan, China is now facing a tsunami of COVID-19 infections. The unprecedented spread of the disease appears to have been fueled by an ill-timed sudden change in COVID-19 policy and the lack of vaccination and boosting. A rethinking of national strategy could still help. (Source: The RAND Blog)
Source: The RAND Blog - January 6, 2023 Category: Health Management Authors: Jennifer Bouey Source Type: blogs
Evidence based medicine and politics
I ' m not sure if you can read this -- I have a cookie that gives me access, but the URL doesn ' t include the proxy server and it appears to be accessible. Let me know. Anyway, it ' sa discussion in NEJM of the U.S. Preventive Services Task Force. The USPSTF is a panel of clinical experts convened by the Agency for Healthcare Research and Quality, AHRQ, which is usually pronounced like ark. It draws on available research to evaluate screening tests and preventive interventions. An A or B grade means they recommend it. A C grade means it might be worthwhile for some people, but you should discuss it with your doctor and ma...
Source: Stayin' Alive - January 5, 2023 Category: American Health Source Type: blogs
Missing links in IHD : What is the relationship between Ischemia & cardiac arrhythmias ?
The term Ischemic heart disease (IHD) was once very popular, but many abandoned it as it became an academic cliche. CAD & CAHD are the other terms that are equally popular and prevalent. Stable IHD was in vogue till recently, which was again replaced by “chronic coronary syndrome’ now. Honestly, I feel the original term IHD to be restored however outdated it may look. it encompasses the entire spectrum of clinical cardiac disorders.
Manifestation of Ischemia heart disease
Angina
Infarction
Cardiac failure
Arrhythmias
Silent ischemia
Sudden cardiac death
The ...
Source: Dr.S.Venkatesan MD - January 5, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Cardiology -unresolved questions Cardiology-Arrhythmias Relationship between Ischemia and arrhytmias Source Type: blogs
Care aides in long-term care were traumatized during COVID-19
The COVID-19 pandemic wreaked havoc on long-term care in Canada. During the first two waves in 2020, over 80 percent of all Canadian COVID-19 deaths happened in long-term care homes. While vaccination and policy changes have helped to reduce the number of deaths, long-term care homes are still experiencing COVID-19 outbreaks and severe staffing shortages.
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Care aides in long-term care were traumatized during COVID-19 originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 4, 2023 Category: General Medicine Authors: Carole Estabrooks, PhD, RN Tags: Conditions COVID Geriatrics Source Type: blogs
Clearing Senescent Cells as a Way to Reduce Cancer Risk Resulting from Persistent Viral Infection
Persistent viral infection, such as by HPV, can result in cancer. Researchers here suggest that senolytic therapies to clear senescent cells can reduce that risk by removing some fraction of the cells most impacted by persistent infection. Senescent cells accumulate with age, but it is becoming clear that they are problematic in many other contexts as well. The ability to remove excess senescent cells with a single treatment via any one of the senolytic therapies under development is a powerful form of intervention that may have many applications beyond the rejuvenation of old tissues.
Senescence represents a uniq...
Source: Fight Aging! - January 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Let teens self-consent to vaccines
I still remember the exhilaration I felt upon learning that my peers and I could finally return to our in-person classrooms. After a year of Zoom lectures, asynchronous exams, and more, the prospect of seeing each other again thrilled us. However, we had not anticipated the constant fear and uncertainty that would accompany this transition.
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Let teens self-consent to vaccines originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 1, 2023 Category: General Medicine Authors: Cady Chen Tags: Policy Infectious Disease Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Going Viral
Helen Bramwell of StatNews is an excellent writer about public health. Here she interviews a bunch of scientists to ask what surprised them about Covid19. It ' s a long read, and I won ' t try to summarize it all, but a couple of points stand out.The first is that most experts originally thought, based on experience with other coronaviruses, that this one would be stable -- that it would not be able to mutate so as to avoid immunity from previous infections or vaccination. Therefore they believed that the pandemic would peak after a few months and we ' d enter an endemic phase. (You might remember those models from t...
Source: Stayin' Alive - December 30, 2022 Category: American Health Source Type: blogs
Measles: a preventable disease that is making a comeback
I see there has been yet another measles outbreak; at the time of writing, the count is 59 in central Ohio. All are either unvaccinated or not fully vaccinated. No doubt local pediatricians are being flooded with worried parents proffering their offspring for viewing with the statement, “Could this rash be measles, doctor?” This certainly
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Measles: a preventable disease that is making a comeback originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 30, 2022 Category: General Medicine Authors: Martin C. Young, MD Tags: Conditions Infectious Disease Pediatrics Source Type: blogs
Regulatory Cooperation in Vaccines in Asia-Pacific Region
Simon Lacey (University of Adelaide), Andrew D. Mitchell (Monash University), Regulatory Cooperation in Vaccines in Asia-Pacific Region (2022): This paper explores the massive strides that were made in response to the COVID-19 pandemic by national drug regulatory agencies (NRAs) in... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - December 30, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Accepting your Future Avatar: Leveraging Digital Twins for Transforming Healthcare
by SMRITI KIRUBANANDAN
A possibility to do better and be better by observing yourself (your twin) reacting to various feeds and gaining the ability to gain better care and improve research, seems like a super power. The concept of a Digital Twin is the ability to replicate a person, an object or a process derived from extracting various data points from internet of things (IOT) that are attached to the original object. One can view how the digital twin responds to various feeds and give us a deeper understanding on the possibilities and impact for the real person or object. Shifting this concept into healthcare, I am ...
Source: The Health Care Blog - December 29, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Burnout Consumer Digital Twin SMRITI KIRUBANANDAN Source Type: blogs
The Atrophy of Lymph Nodes with Age Negatively Impacts Immune Function
The lymphatic system allows rapid transit of large numbers of immune cells throughout the body. Scattered through this system of lymphatic vessels are the lymph nodes. Lymph nodes are vital to the function of the immune system, acting as meeting places where immune cells can communicate to effectively coordinate the response to pathogens. With age, lymph node structure begins to break down, however, becoming fibrotic, or the active tissue replaced by fat. Researchers have shown that this is an obstacle to rejuvenation of the adaptive immune system; one can regrow the atrophied thymus to provide a supply of new T cells, but...
Source: Fight Aging! - December 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
TWiV 966: 1918 influenza with Jeffery Taubenberger
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus. (Source: virology blog)
Source: virology blog - December 23, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology 1918 influenza pandemic Spanish flu vaccine viral virus viruses zoonosis Source Type: blogs
