Nobody wants this job. Should physicians stick around?
As I enter the patient exam room, the first question is no longer “When can I get my COVID-19 vaccine?” but rather, “Are you leaving? My old doctor left. You are my fifth doctor in three years. What is happening?” Nowadays, I spend more time educating patients about the visible cracks our medical system flaunts. Read more… Nobody wants this job. Should physicians stick around? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 17, 2023 Category: General Medicine Authors: Tags: Physician Primary Care Source Type: blogs

A Lysosomal Overloading Hypothesis of Alzheimer's Disease
Novel immunotherapies for Alzheimer's disease have in recent years finally succeeded in clearing toxic extracellular amyloid-β aggregates from the brain in human clinical trials. Nonetheless, this advance has failed to meaningfully improve patient outcomes. This outcome has led to renewed theorizing on the mechanisms of Alzheimer's disease, in search of an explanation as to how amyloid-β can be so clearly associated with the condition, but fail as a target for therapy. Some researchers focus on chronic inflammation as the primary mechanism of disease progression, seeing amyloid-β aggregation as a side-effect at b...
Source: Fight Aging! - March 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Reprogramming Tumor Cells into Antigen-Presenting Cells
Today's research materials describe a clever approach to cancer immunotherapy, focused on the goal of enabling the immune system to better identify cancerous cells. In the past, researchers have made some inroads in training the immune system to attack specific target molecules characteristic of cancerous cells, but this is a slow and expensive process when progressing from single target to single target. Further, any given cancer might be capable of evolving to function without exhibiting any one specific target molecule, and only some cancers of a particular type will exhibit that specific signature molecule to start wit...
Source: Fight Aging! - March 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The vaccination dilemma: Protecting patient rights or caregiver freedom?
Recently, I heard a news report regarding several state attorneys general suing the federal government to eliminate the requirement that health care providers be immunized against COVID. They argued that as fully immunized individuals still contract COVID, and that allowing unimmunized people to be rehired would relieve provider shortage, the regulation was unhelpful. Initially, I Read more… The vaccination dilemma: Protecting patient rights or caregiver freedom? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 10, 2023 Category: General Medicine Authors: Tags: Conditions COVID Infectious Disease Source Type: blogs

Another New Player in the Thymus Regeneration Space
It seems there is ever more enthusiasm for regenerating the thymus these days, which is welcome. A number of companies are out there pursuing widely divergent scientific programs to achieve this goal, at varying stages of progress towards the clinic. At some point, someone will figure out an optimal path past the various challenges presented by the location and biology of the thymus to produce a large regrowth of this organ in older individuals. The company noted here, Thymmune Therapeutics, is taking the cell therapy approach, which I think to be one of the more viable options, given that a few cell types have been shown ...
Source: Fight Aging! - March 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Pandemic preparedness for the real world: why we must invest in equitable, ethical and effective approaches to help prepare for the next pandemic
This report warns the global health community to think beyond vaccines and lockdowns, proposing investment in a five point action framework for pandemic preparedness which responds to people ’s experiences, knowledge and needs. The proposed five areas for investment are: health professionals; diverse knowledge, expertise and perspectives; reform of health, social and other systems and structures to support resilience to disease crises; people’s trust in politics; and ethics and soci al justice.ReportInstitute of Development Studies - news (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - March 10, 2023 Category: UK Health Authors: The King ' s Fund Library Tags: Covid-19 Public health and health inequalities Source Type: blogs

Featured Health IT Jobs – Senior Epic Application Analyst
We like to regularly feature a healthcare IT job that might be of interest to readers. Today, we’re featuring the Senior Epic Application Analyst position that was recently posted on Healthcare IT Central. This position was posted by Yakima Valley Farm Workers Clinic and is located in Toppenish, Washington. Here’s a description of the position: YVFWC has a compulsory vaccination policy including the Covid-19 primary series, the organization does not mandate the Covid-19 booster although it is offered through our employee health department. Medical and religious exemptions to the primary series will be considered ...
Source: EMR and HIPAA - March 8, 2023 Category: Information Technology Authors: John Lynn Tags: Career and Jobs Healthcare IT Epic Jobs Featured Opportunities Health IT Careers Health IT Jobs Healthcare IT Jobs Job Seekers Senior Epic Application Analyst Yakima Valley Farm Workers Clinic Source Type: blogs

H5N1 – It ’ s All About the Transmission
by Gertrud U. Rey Recent news headlines have been highlighting the global spread of H5N1, the strain of influenza virus that is typically associated with “bird flu.” This outbreak is the largest in recorded history, involving at least 50 million dead birds and countless non-human mammals, including sea lions, otters, mink, foxes, cats, dogs, and […] (Source: virology blog)
Source: virology blog - March 2, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey avian influenza H5N1 bird flu human-to-human transmission lower respiratory tract pandemic sialic acid upper respiratory tract vaccine Source Type: blogs

How Can Health IT Help Reform the CDC?
This article summarizes their responses. Paths to Interoperability A recent article exposes the woeful silo-ing of public health: Data often has to be faxed and re-entered into new systems manually. I wonder whether the path to complete integration requires adopting a single, worldwide, FHIR-based standard (which is time-consuming and probably requires jettisoning old database systems) or programming these systems to translate data from one format to another. I heard details about problems with COVID-19 lab reporting at a state level from Dr. Paulo Pinho, vice president & medical director of innovation at Availity Clin...
Source: EMR and HIPAA - February 28, 2023 Category: Information Technology Authors: Andy Oram Tags: Healthcare IT Regulations 21st Century Cures Act Amazon Amazon Healthcare Amazon S3 Availity Availity Clinical Solutions CDC Data Exchange Diameter Health EMPI FDA Gus Malezis Health Gorilla hl7 Imprivata Interoperability Source Type: blogs

Let ’ s Do Public Health Better
BY KIM BELLARD Eric Reinhart, who describes himself as “a political anthropologist, psychoanalyst, and physician,” has had a busy month. He started with an essay in NEJM about “reconstructive justice,” then an op-ed in The New York Times on how our health care system is demoralizing the physicians who work in it, and then the two that caught my attention: companion pieces in The Nation and Stat News about reforming our public health “system” from a physician-driven one to a true community health one.  He’s preaching to my choir. I wrote almost five years ago: “We need to stop viewing public healt...
Source: The Health Care Blog - February 28, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Dr. Reinhart gun violence Kim Bellard Opioid Addiction public health Source Type: blogs

The power of personal stories in vaccination awareness
“How was your Thanksgiving?” This may seem like an odd question to ask at the end of January, but I had not seen Ahmed (not real name) and his mother since his last infant well visit in late October. This family moved to central Ohio about two years ago, escaping the ravages of living in Read more… The power of personal stories in vaccination awareness originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 27, 2023 Category: General Medicine Authors: Tags: Physician Pediatrics Source Type: blogs

HIV Vaccine Candidate Stops Virus As it Enters Body
Researchers at the Texas Biomedical Research Institute are developing a vaccine candidate against HIV. The vaccine is intended to block HIV entry into the body and is administered to the mucosal lining of the rectum and vagina to achieve this. The formulation then stimulates antibodies against HIV in precisely the areas where the virus first enters the body’s cells. Cleverly, the researchers designed the vaccine to target the basal cells of the epithelium, which then give rise to a constant supply of epithelial cells to replace cells that are routinely sloughed off. This may lead to long-term protection against HIV with ...
Source: Medgadget - February 27, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health AIDS HIV txbiomed Source Type: blogs

Myocarditis update from Sweden
BY ANISH KOKA The COVID19/vaccine myocarditis debate continues in large part because our public health institutions are grossly mischaracterizing the risks and benefits of vaccines to young people. A snapshot of what the establishment says as it relates to the particular area of concern: college vaccine mandates: Dr. Arthur Reingold, an epidemiology professor at UC-Berkeley, notes that UC also requires immunizations for measles and chickenpox, and people still are dying from COVID at rates that exceed those for influenza. As of Feb. 1, there were more than 400 COVID deaths a day across the U.S. “The arg...
Source: The Health Care Blog - February 27, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka covid19 myocarditis Sweden Source Type: blogs

Avian influenza, bird flu, H5N1
A bird flu pandemic has killed thousands of wild birds over the last couple of years. Scientists have now seen infection in mammals, and very recently a person died from avian influenza and several close contacts show signs of  infection. The concern is that we might be headed for another H5N1 pandemic. Previous strains of H5N1 that infected people had a mortality rate of 60 percent. Avian influenza, bird flu, H5N1 There are fifteen known variants of avian influenza. The most virulent, and usually fatal in birds, are the H5 and H7 strains. There are then nine variants of the H5 strain and the type of most concern because ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 27, 2023 Category: Science Authors: David Bradley Tags: Bird Flu Health and Medicine Vaccines Source Type: blogs