Associations between pregnancy-related factors and birth characteristics with risk of rare uterine cancer subtypes: a Nordic population-based case –control study
ConclusionOur study provides evidence that risk factors for uterine sarcoma and MMMT, previously grouped with uterine sarcomas, vary substantially. Additionally, MMMT and type I endometrial carcinomas are more similar than uterine sarcoma in that pregnancy complications like gestational hypertension and preeclampsia were associated with reduced risks of both but not uterine sarcoma, suggesting different etiologies. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - December 22, 2023 Category: Cancer & Oncology Source Type: research
Prognostic Factors for Uterine Sarcoma and Carcinosarcoma: Insights from a 10-Year Follow-Up Study
CONCLUSIONS A 10-year follow-up of patients with uterine sarcoma indicates that age above 60 years at diagnosis and high p53 expression and elevated CA125 levels before treatment can be independent prognostic factors. The high diagnostic sensitivity of sTNF RI and VEGF suggests the possibility of using these biomarkers in the early diagnosis of uterine sarcomas.PMID:38058118 | DOI:10.12659/MSM.941562 (Source: Cancer Control)
Source: Cancer Control - December 7, 2023 Category: Cancer & Oncology Authors: Beata Kotowicz Anna Da ńska-Bidzińska Ma łgorzata Fuksiewicz Anna Nasierowska-Guttmejer Dorota Raczkiewicz Mariusz Gujski Szymon Pi ątek Mariusz Bidzi ński Source Type: research
Prognostic Factors for Uterine Sarcoma and Carcinosarcoma: Insights from a 10-Year Follow-Up Study
CONCLUSIONS A 10-year follow-up of patients with uterine sarcoma indicates that age above 60 years at diagnosis and high p53 expression and elevated CA125 levels before treatment can be independent prognostic factors. The high diagnostic sensitivity of sTNF RI and VEGF suggests the possibility of using these biomarkers in the early diagnosis of uterine sarcomas.PMID:38058118 | DOI:10.12659/MSM.941562 (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 7, 2023 Category: Research Authors: Beata Kotowicz Anna Da ńska-Bidzińska Ma łgorzata Fuksiewicz Anna Nasierowska-Guttmejer Dorota Raczkiewicz Mariusz Gujski Szymon Pi ątek Mariusz Bidzi ński Source Type: research
Ultrasound features using MUSA terms and definitions in uterine sarcoma and leiomyoma: retrospective cohort study
CONCLUSIONS: A postmenopausal patient, presenting with abnormal uterine bleeding and a new or growing mesenchymal mass with irregular tumor borders at ultrasonography, moderate to abundant intralesional vascularity, presence of cystic areas and absence of calcifications, carries a higher risk of having a uterine sarcoma. The interobserver agreement for most MUSA terms and definitions is moderate. Future studies should validate the above clinical and ultrasound findings in a prospective multicenter collection of uterine mesenchymal tumors. This article is protected by copyright. All rights reserved.PMID:37970762 | DOI:10.10...
Source: The Ultrasound Review of Obstetrics and Gynecology - November 16, 2023 Category: Radiology Authors: C De Bruyn J Ceusters K Vanden Brande S Timmerman W Froyman D Timmerman A-S Van Rompuy A Coosemans T Van den Bosch Source Type: research
Ultrasound features using MUSA terms and definitions in uterine sarcoma and leiomyoma: retrospective cohort study
CONCLUSIONS: A postmenopausal patient, presenting with abnormal uterine bleeding and a new or growing mesenchymal mass with irregular tumor borders at ultrasonography, moderate to abundant intralesional vascularity, presence of cystic areas and absence of calcifications, carries a higher risk of having a uterine sarcoma. The interobserver agreement for most MUSA terms and definitions is moderate. Future studies should validate the above clinical and ultrasound findings in a prospective multicenter collection of uterine mesenchymal tumors. This article is protected by copyright. All rights reserved.PMID:37970762 | DOI:10.10...
Source: The Ultrasound Review of Obstetrics and Gynecology - November 16, 2023 Category: Radiology Authors: C De Bruyn J Ceusters K Vanden Brande S Timmerman W Froyman D Timmerman A-S Van Rompuy A Coosemans T Van den Bosch Source Type: research
Ultrasound features using MUSA terms and definitions in uterine sarcoma and leiomyoma: retrospective cohort study
CONCLUSIONS: A postmenopausal patient, presenting with abnormal uterine bleeding and a new or growing mesenchymal mass with irregular tumor borders at ultrasonography, moderate to abundant intralesional vascularity, presence of cystic areas and absence of calcifications, carries a higher risk of having a uterine sarcoma. The interobserver agreement for most MUSA terms and definitions is moderate. Future studies should validate the above clinical and ultrasound findings in a prospective multicenter collection of uterine mesenchymal tumors. This article is protected by copyright. All rights reserved.PMID:37970762 | DOI:10.10...
Source: The Ultrasound Review of Obstetrics and Gynecology - November 16, 2023 Category: Radiology Authors: C De Bruyn J Ceusters K Vanden Brande S Timmerman W Froyman D Timmerman A-S Van Rompuy A Coosemans T Van den Bosch Source Type: research
Ultrasound features using MUSA terms and definitions in uterine sarcoma and leiomyoma: retrospective cohort study
CONCLUSIONS: A postmenopausal patient, presenting with abnormal uterine bleeding and a new or growing mesenchymal mass with irregular tumor borders at ultrasonography, moderate to abundant intralesional vascularity, presence of cystic areas and absence of calcifications, carries a higher risk of having a uterine sarcoma. The interobserver agreement for most MUSA terms and definitions is moderate. Future studies should validate the above clinical and ultrasound findings in a prospective multicenter collection of uterine mesenchymal tumors. This article is protected by copyright. All rights reserved.PMID:37970762 | DOI:10.10...
Source: The Ultrasound Review of Obstetrics and Gynecology - November 16, 2023 Category: Radiology Authors: C De Bruyn J Ceusters K Vanden Brande S Timmerman W Froyman D Timmerman A-S Van Rompuy A Coosemans T Van den Bosch Source Type: research
Ulipristal acetate, a selective progesterone receptor modulator, induces cell death via inhibition of STAT3/CCL2 signaling pathway in uterine sarcoma
In this study, we examined the efficacy of UPA in uterine sarcoma with in vitro and in vivo animal models. Cytotoxicity of UPA was determined in uterine sarcoma cell lines (MES-SA, SK-UT-1, and SK-LMS-1). Apoptotic genes and signaling pathways affected by UPA were analyzed by complementary DNA (cDNA) microarray of uterine sarcoma cell lines and western blot, respectively. An in vivo efficacy of UPA was examined with uterine sarcoma cell line- and patient-derived xenograft (PDX) mice models. UPA inhibited cell growth in uterine sarcoma cell lines and primary culture cells from a PDX mouse (PDX-C). cDNA microarray analysis r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 4, 2023 Category: Drugs & Pharmacology Authors: Jae Ryoung Hwang Young-Jae Cho Ji-Yoon Ryu Ju-Yeon Choi Jung-Joo Choi Jason K Sa Hyun-Soo Kim Jeong-Won Lee Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
