Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Uterine tumor resembling high-grade endometrial mesenchymal sarcoma with GATAD2B-MMRN1 fusion
This report describes a 48-year-old woman who underwent laparoscopic myomectomy and relapsed within 5 years with a large mass in the pelvic cavity. Morphologically, the tumor was composed of oval cells and small arteries, and the cells showed moderate to severe atypia. Immunohistochemical results showed that the tumor cells expressed desmin, smooth muscle actin, and h-caldesmon, which supported myogenic differentiation. They were strongly positive for Cyclin D1, estrogen receptors (ER), and estrogen receptors (PR), supporting their origin from uterine mesenchymal cells. Next-generation sequencing (NGS) revealed a GATAD2B::...
Source: International Journal of Clinical and Experimental Pathology - October 11, 2023 Category: Pathology Authors: Mengdie Yue Junbo Hu Xiaohong Min Hui Xu Source Type: research
Diagnosis of uterine sarcomas and rare uterine mesenchymal tumours with malignant potential. Guidelines of the French Sarcoma Group and Rare Gynaecological Tumours
Bull Cancer. 2023 Oct 6:S0007-4551(23)00348-X. doi: 10.1016/j.bulcan.2023.08.002. Online ahead of print.ABSTRACTThe landscape of uterine sarcomas is becoming more complex with the description of new entities associated with recurrent driver molecular alterations. Uterine sarcomas, in analogy with soft tissue sarcomas, are distinguished into complex genomic and simple genomic sarcomas. Leiomyosarcomas and undifferentiated uterine sarcomas belong to complex genomic sarcomas group. Low-grade and high-grade endometrial stromal sarcomas, other rare tumors associated with fusion transcripts (such as NTRK, PDGFB, ALK, RET ROS1) a...
Source: Bulletin du Cancer - October 8, 2023 Category: Cancer & Oncology Authors: Sabrina Croce Mojgan Devouassoux-Shisheboran Patricia Pautier Isabelle Ray-Coquard Isabelle Treilleux Agn ès Neuville Laurent Arnould Pierre-Alexandre Just Marie Aude Le Frere Belda Gerlinde Averous Agn ès Leroux Guillaume Bataillon Eliane Mery Delphine Source Type: research
Germline pathogenic SMARCA4 variants in neuroblastoma
Heterozygous germline pathogenic variants (GPVs) in SMARCA4, the gene encoding the ATP-dependent chromatin remodelling protein SMARCA4 (previously known as BRG1), predispose to several rare tumour types, including small cell carcinoma of the ovary, hypercalcaemic type, atypical teratoid and malignant rhabdoid tumour, and uterine sarcoma. The increase in germline testing of SMARCA4 in recent years has revealed putative GPVs affecting SMARCA4 in patients with other cancer types. Here we describe 11 patients with neuroblastoma (NBL), including 4 previously unreported cases, all of whom were found to harbour heterozygous germl...
Source: Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Witkowski, L., Nichols, K. E., Jongmans, M., van Engelen, N., de Krijger, R. R., Herrera-Mullar, J., Tytgat, L., Bahrami, A., Mar Fan, H., Davidson, A. L., Robertson, T., Anderson, M., Hasselblatt, M., Plon, S. E., Foulkes, W. D. Tags: Cancer genetics Source Type: research
ASO Visual Abstract: Impact of Hospital Case Volume on Uterine Sarcoma Prognosis: SARCUT Study Subanalysis
Ann Surg Oncol. 2023 Aug 30. doi: 10.1245/s10434-023-14209-5. Online ahead of print.NO ABSTRACTPMID:37648890 | DOI:10.1245/s10434-023-14209-5 (Source: Ann Oncol)
Source: Ann Oncol - August 30, 2023 Category: Cancer & Oncology Authors: Mikel Gorostidi Yusuf Yildirim Ronalds Macuks Rosanna Mancari Patriciu Achimas-Cadariu Eduardo Iba ñez Giacomo Corrado Arnoldas Bartusevicius Olena Sukhina Ignacio Zapardiel SARCUT Study Group Source Type: research
ASO Visual Abstract: Impact of Hospital Case Volume on Uterine Sarcoma Prognosis: SARCUT Study Subanalysis
Ann Surg Oncol. 2023 Aug 30. doi: 10.1245/s10434-023-14209-5. Online ahead of print.NO ABSTRACTPMID:37648890 | DOI:10.1245/s10434-023-14209-5 (Source: Ann Oncol)
Source: Ann Oncol - August 30, 2023 Category: Cancer & Oncology Authors: Mikel Gorostidi Yusuf Yildirim Ronalds Macuks Rosanna Mancari Patriciu Achimas-Cadariu Eduardo Iba ñez Giacomo Corrado Arnoldas Bartusevicius Olena Sukhina Ignacio Zapardiel SARCUT Study Group Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research
