E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways
Int J Mol Sci. 2023 May 31;24(11):9606. doi: 10.3390/ijms24119606.ABSTRACTE7050 is an inhibitor of VEGFR2 with anti-tumor activity; however, its therapeutic mechanism remains incompletely understood. In the present study, we aim to evaluate the anti-angiogenic activity of E7050 in vitro and in vivo and define the underlying molecular mechanism. It was observed that treatment with E7050 markedly inhibited proliferation, migration, and capillary-like tube formation in cultured human umbilical vein endothelial cells (HUVECs). E7050 exposure in the chick embryo chorioallantoic membrane (CAM) also reduced the amount of neovesse...
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Tsung-Teng Huang Chuan-Mu Chen Song-Shu Lin Ying-Wei Lan Hsu-Chen Cheng Kong-Bung Choo Ching-Chiung Wang Tse-Hung Huang Kowit-Yu Chong Source Type: research
Prognostic factors, oncological treatment and outcomes of uterine sarcoma: 10 years ’ clinical experience from a tertiary care center in Pakistan
This study aims to investig... (Source: BMC Cancer)
Source: BMC Cancer - June 5, 2023 Category: Cancer & Oncology Authors: Saqib Raza Khan, Salman Muhammad Soomar, Tamana Asghari, Arsalan Ahmed and Munira Shabbir Moosajee Tags: Research Source Type: research
NTRK-rearranged uterine sarcoma: A case report
Asian J Surg. 2023 May 31:S1015-9584(23)00759-5. doi: 10.1016/j.asjsur.2023.05.088. Online ahead of print.NO ABSTRACTPMID:37268470 | DOI:10.1016/j.asjsur.2023.05.088 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 2, 2023 Category: Surgery Authors: Xueting Fang Ruihong Huang Zhilong Zhang Source Type: research
High negative prediction for the Basel sarcoma score: Sonographic assessment of features suspicious of uterine sarcoma
CONCLUSION: BSS can help distinguishing between myomas and sarcomatous masses, with high NPV. Caution is required when >1 criterion is present. As a simple tool, it could easily be integrated into routine myoma sonographic examination and help develop standardized assessment of uterine masses for better preoperative triage.PMID:37210928 | DOI:10.1016/j.ygyno.2023.05.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 21, 2023 Category: Cancer & Oncology Authors: Alexandra Maria Knipprath-M észáros Alessandra Tozzi Annkathrin Butensch ön Hubertina Reina Andreas Schoetzau C éline Montavon Viola Heinzelmann-Schwarz Gwendolin Manegold-Brauer Source Type: research
