The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
Global Trends in Research Related to Emergence Agitation From 1978 to 2023: A Bibliometric Analysis
CONCLUSIONS: The study mapped the knowledge structure of EA and identified six prominent research directions, four drugs of significant research interest, and emerging thematic trends. These findings offer insights into the current state of research on EA, providing a comprehensive view of the field's landscape.PMID:38219083 | DOI:10.1016/j.jopan.2023.10.017 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - January 14, 2024 Category: Nursing Authors: Xin Li Yu Sun Source Type: research
MiR-181a-5p knockdown ameliorates sevoflurane anesthesia-induced neuron injury via regulation of the DDX3X/Wnt/ β-catenin signaling axis
Exp Brain Res. 2024 Jan 13. doi: 10.1007/s00221-023-06739-x. Online ahead of print.ABSTRACTSevoflurane is one of the most widely used inhaled anesthetics. MicroRNAs (miRNAs) have been demonstrated to affect sevoflurane anesthesia-induced neuron damage. The purpose of this study was to investigate the role and mechanism of miR-181a-5p in sevoflurane-induced hippocampal neuronal injury. Primary hippocampal neurons were identified using microscopy and immunofluorescence. The viability and apoptosis of sevoflurane anesthesia-induced neurons were detected by cell counting kit-8 (CCK-8) assay and terminal-deoxynucleoitidyl trans...
Source: Experimental Brain Research - January 13, 2024 Category: Neuroscience Authors: Yuqi She Zhijun Chen Li Zhang Yuan Wang Source Type: research
A prospective-randomized placebo-controlled trial comparing the effects of nebulized dexmedetomidine v/s dexmedetomidine-lignocaine mixture on intraoperative hemodynamics and surgical field quality in patients undergoing endoscopic transnasal transsphenoidal pituitary tumor surgery
CONCLUSION: The administration of nebulized dexmedetomidine, both alone and in combination with lignocaine, resulted in stable hemodynamics, favorable operative conditions, reduced anesthetic requirement, and facilitated prompt emergence during TNTSS. Nebulized dexmedetomidine proved superior to its combination with lignocaine across all evaluated parameters.PMID:38213443 | PMC:PMC10783663 | DOI:10.25259/SNI_858_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - January 12, 2024 Category: Neurosurgery Authors: Ranganatha Praveen Manikandan Sethuraman Smita Vimala Unnikrishnan Prathapadas Ajay Prasad Hrishi Prakash Nair Sarath Surendran Arvin Ahuja Revikrishnan Sreekumar Bijith Vishnu Matham Gowtham Source Type: research
Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway
In conclusion, SPC alleviates neuronal apoptosis in the hippocampus CA1 area of HIBD rats by inhibiting the endoplasmic reticulum stress pathway PERK/ATF4/CHOP, thereby mitigating HIBD in rats.PMID:38194851 | DOI:10.1016/j.tice.2023.102289 (Source: Tissue and Cell)
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Qionghua Hu Lingqin Qiu Li Ge Yi Wei Source Type: research
Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway
In conclusion, SPC alleviates neuronal apoptosis in the hippocampus CA1 area of HIBD rats by inhibiting the endoplasmic reticulum stress pathway PERK/ATF4/CHOP, thereby mitigating HIBD in rats.PMID:38194851 | DOI:10.1016/j.tice.2023.102289 (Source: Tissue and Cell)
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Qionghua Hu Lingqin Qiu Li Ge Yi Wei Source Type: research
Retracted: GLP-1 Analog Alleviated Cognitive Dysfunction in Aged Rats Anaesthetized with Sevoflurane
Biomed Res Int. 2023 Dec 29;2023:9862825. doi: 10.1155/2023/9862825. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/9339824.].PMID:38188842 | PMC:PMC10769629 | DOI:10.1155/2023/9862825 (Source: Biomed Res)
Source: Biomed Res - January 8, 2024 Category: Research Authors: BioMed Research International Source Type: research
Retracted: GLP-1 Analog Alleviated Cognitive Dysfunction in Aged Rats Anaesthetized with Sevoflurane
Biomed Res Int. 2023 Dec 29;2023:9862825. doi: 10.1155/2023/9862825. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/9339824.].PMID:38188842 | PMC:PMC10769629 | DOI:10.1155/2023/9862825 (Source: Biomed Res)
Source: Biomed Res - January 8, 2024 Category: Research Authors: BioMed Research International Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Impact of prognostic nutritional index change on prognosis after colorectal cancer surgery under propofol or sevoflurane anesthesia
The alteration of the prognostic nutritional index (PNI) or the utilization of distinct anesthesia strategies has been linked to the prognosis of various cancer types, but the existing evidence is limited and ... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - January 3, 2024 Category: Anesthesiology Authors: Longtang Zhang, Chong Liu, Qiang Yan and Xiaoli Cai Tags: Research Source Type: research
