Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis
CONCLUSIONS: LRG induced autophagy activation can maintain cell homeostasis and promote cell survival by blocking the apoptotic pathway. LRG could improve Sev-induced POCD via activating autophagy, inhibiting apoptosis, and regulating AMPK/mTOR signaling pathway. This study provides a novel therapeutic strategy for the prevention and treatment of POCD.PMID:38364258 | DOI:10.18632/aging.205558 (Source: Aging)
Source: Aging - February 16, 2024 Category: Biomedical Science Authors: Ying Hu Haijin Huang Yao Jiang Jingling Zhang Yang Zhang Ying Tian Qin Zhang Source Type: research
Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis
CONCLUSIONS: LRG induced autophagy activation can maintain cell homeostasis and promote cell survival by blocking the apoptotic pathway. LRG could improve Sev-induced POCD via activating autophagy, inhibiting apoptosis, and regulating AMPK/mTOR signaling pathway. This study provides a novel therapeutic strategy for the prevention and treatment of POCD.PMID:38364258 | DOI:10.18632/aging.205558 (Source: Aging)
Source: Aging - February 16, 2024 Category: Biomedical Science Authors: Ying Hu Haijin Huang Yao Jiang Jingling Zhang Yang Zhang Ying Tian Qin Zhang Source Type: research
Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes
This study was undertaken to compare the effects of sevoflurane and propofol anesthesia on perioperative hemodynamics and perioperative adverse cardiovascular events (PACE) in elderly patients with diabetes undergoing general anesthesia for noncardiac surgery.METHODS: According to the random number table (n = 40), 80 patients with diabetes undergoing noncardiac general anesthesia were divided into a control group and an observation group. In the control group, the patients were given propofol 4 to 6 mg/(kg·h), continuously pumped to maintain anesthesia. In the observation group, the patients were given maintained concentr...
Source: Clinical Therapeutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Liling Jia Hongfeng Li Tuping Li Source Type: research
Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes
This study was undertaken to compare the effects of sevoflurane and propofol anesthesia on perioperative hemodynamics and perioperative adverse cardiovascular events (PACE) in elderly patients with diabetes undergoing general anesthesia for noncardiac surgery.METHODS: According to the random number table (n = 40), 80 patients with diabetes undergoing noncardiac general anesthesia were divided into a control group and an observation group. In the control group, the patients were given propofol 4 to 6 mg/(kg·h), continuously pumped to maintain anesthesia. In the observation group, the patients were given maintained concentr...
Source: Clinical Therapeutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Liling Jia Hongfeng Li Tuping Li Source Type: research
Sevoflurane causes cognitive impairment by inducing iron deficiency and inhibiting the proliferation of neural precursor cells in infant mice
CONCLUSION: The results from the present study demonstrated that Sev-induced iron deficiency might be a new mechanism of cognitive impairment caused by inhaled anesthetics in infant mice. Iron supplementation before anesthesia is an effective strategy to prevent cognitive impairment caused by Sev in infants.PMID:38334030 | PMC:PMC10853893 | DOI:10.1111/cns.14612 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Yong Zuo Jinhong Xie Xue Zhang Anand Thirupathi Xiaopeng Liu Di Zhang Jianhua Zhang Zhenhua Shi Source Type: research
Dysregulation of iron homeostasis and ferroptosis in sevoflurane and isoflurane associated perioperative neurocognitive disorders
CNS Neurosci Ther. 2024 Feb;30(2):e14553. doi: 10.1111/cns.14553.ABSTRACTIn recent years, sevoflurane and isoflurane are the most popular anesthetics in general anesthesia for their safe, rapid onset, and well tolerant. Nevertheless, many studies reported their neurotoxicity among pediatric and aged populations. This effect is usually manifested as cognitive impairment such as perioperative neurocognitive disorders. The wide application of sevoflurane and isoflurane during general anesthesia makes their safety a major health concern. Evidence indicates that iron dyshomeostasis and ferroptosis may establish a role in neurot...
Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Mengrong Miao Yaqian Han Yangyang Wang Jie Wang Ruilou Zhu Yitian Yang Ningning Fu Ningning Li Mingyang Sun Jiaqiang Zhang Source Type: research
Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia ‑reperfusion injury in sevoflurane‑treated rats
Mol Med Rep. 2024 Mar;29(3):54. doi: 10.3892/mmr.2024.13178. Epub 2024 Feb 9.ABSTRACTThe aim of the present study was to examine the effect of fullerenol C60 on lung and kidney tissue in sevoflurane‑treated rats with lower extremity ischemia‑reperfusion (IR) injury. A total of 30 Wistar albino rats weighing 225‑275 g were used and were equally divided into five groups (n=6/group): i) Sham; ii) IR; iii) IR‑fullerenol C60 (IR‑FUL); iv) IR‑sevoflurane; and v) IR‑fullerenol C60‑sevoflurane (IR‑FUL‑SEVO). Fullerenol C60 was administered intraperitoneally prior to lower extremity IR induction and sevoflurane ...
Source: Molecular Medicine Reports - February 9, 2024 Category: Molecular Biology Authors: Ay şe Hande Arpaci Zeynep K öksal Zeynep Yi ğman Ay şegül Küçük Volkan Şivgin Mustafa Arslan Mustafa Kavut çu Saadet Özen Akarca Di Zakar Source Type: research
The effect of sevoflurane exposure on cell ‐type‐specific changes in the prefrontal cortex in young mice
This study focuses on investigating the impact of neonatal sevoflurane exposure on cell-type-specific alterations in the prefrontal cortex (PFC) of young mice. Neonatal mice were subjected to either control treatment (60% oxygen balanced with nitrogen) or sevoflurane anesthesia (3% sevoflurane in 60% oxygen balanced with nitrogen) for 2 hours on postnatal days (PNDs) 6, 8, and 10. Behavioral tests and single-nucleus RNA sequencing (snRNA-seq) of the PFC were conducted from PNDs 31 to 37. Mechanistic exploration included clustering analysis, identification of differentially expressed genes (DEGs), enrichment analyses, si...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Bao ‐Jian Zhao,
Shao‐Yong Song,
Wei‐Ming Zhao,
Han‐Bing Xu,
Ke Peng,
Xi‐Sheng Shan,
Qing‐Cai Chen,
Hong Liu,
Hua‐Yue Liu,
Fu‐Hai Ji Tags: ORIGINAL ARTICLE Source Type: research
Melatonin Ameliorates Sevoflurane Anesthesia-Induced Deficits in Learning and Memory of Aged Mice Through Nrf2 Signaling Related Ferroptosis
Rejuvenation Research, Ahead of Print. (Source: Rejuvenation Research)
Source: Rejuvenation Research - February 6, 2024 Category: Genetics & Stem Cells Authors: Honghu Ni Yijia Chen Yongxiang Xie Source Type: research
Cerebral oxygenation saturation in childhood: difference by age and comparison of two cerebral oximetry algorithms
In this study, we aimed to assess and compare rSO2 levels in pediatric patients of different age groups undergoing non-cardiac surgery. We used two oximeters, tNIRS-1, which uses time-resolved spectroscopy, and conventional INVOS 5100C. Seventy-eight children —26 infants, 26 toddlers, and 26 schoolchildren—undergoing non-cardiac surgery were included. We investigated the differences in the rSO2 levels among the age groups and the correlation between the models and physiological factors influencing the rSO2 values. rSO2 measured by INVOS 5100C was significantly lower in infants than those in other patients. rSO2 measure...
Source: Journal of Clinical Monitoring and Computing - February 4, 2024 Category: Information Technology Source Type: research
Sevoflurane Postconditioning Protects From an Early Neurological Deficit After Subarachnoid Hemorrhage: Results of a Randomized Laboratory Study in Rats
CONCLUSIONS: Sevoflurane postconditioning improves survival by 23% (SAH-sevoflurane versus SAH-propofol). The sevoflurane intervention could attenuate the early neurologic deficit, while the long-term outcome was similar across the groups. A higher vascular density close to the SAH area in the propofol group was not associated with improved outcomes.PMID:38259181 | DOI:10.1213/ANE.0000000000006829 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - January 23, 2024 Category: Anesthesiology Authors: Laurent Morax Beatrice Beck-Schimmer Jonah Neff Mattia Mueller Renata Flury-Frei Martin Schl äpfer Source Type: research
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice
Transl Res. 2024 Jan 19:S1931-5244(24)00017-3. doi: 10.1016/j.trsl.2024.01.007. Online ahead of print.ABSTRACTProlonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting genetic material. Nevertheless, the specific mechanisms by which miRNAs in ADEs contribute to sevoflurane-in...
Source: Translational Research : the journal of laboratory and clinical medicine - January 21, 2024 Category: Laboratory Medicine Authors: Junhua Li Hui Xu Kun Zhang Yafang Liu Cong Zeng Yanni Fu Yujuan Li Source Type: research
Retraction notice to "Inhibition of miR-495-3p ameliorated sevoflurane induced damage through BDNF/ERK/CREB signaling pathways in HT22 cells" [Transplant Immunology, Volume75, December 2022, 101708]
Transpl Immunol. 2024 Jan 18:101992. doi: 10.1016/j.trim.2024.101992. Online ahead of print.NO ABSTRACTPMID:38242727 | DOI:10.1016/j.trim.2024.101992 (Source: Transplant Immunology)
Source: Transplant Immunology - January 19, 2024 Category: Transplant Surgery Authors: Xiaomei Chen Chongyi Li Rui Zeng Ling Qiu Jianhang Huang Ning Wang Xia Ren Xingwu Lin Source Type: research
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice
Prolonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting genetic material. Nevertheless, the specific mechanisms by which miRNAs in ADEs contribute to sevoflurane-induced cognitive deficit are currently unknown. (Source: Translational Research)
Source: Translational Research - January 18, 2024 Category: Research Authors: Junhua Li, Hui Xu, Kun Zhang, Yafang Liu, Cong Zeng, Yanni Fu, Yujuan Li Source Type: research
The halothane era in pediatric anesthesia: The convergence of a cardiac depressant anesthetic with the immature myocardium of infancy
Paediatr Anaesth. 2024 Jan 17. doi: 10.1111/pan.14840. Online ahead of print.ABSTRACTIntroduced in the late 1950s, halothane became the anesthetic of choice for inhalational induction of children for over 40 years. Halothane enjoyed a generally favorable safety record during its time, but its cardiac contractility depressant effect-well tolerated by most age groups-was profoundly heightened in neonates and infants, leading to increased incidences of hypotension and cardiac arrest. The neonatal myocardium is immature and is characterized by poor ventricular compliance, poor contractility due to fewer contractile elements, i...
Source: Paediatric Anaesthesia - January 17, 2024 Category: Anesthesiology Authors: Robert H Friesen Source Type: research
