Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis
(Source: Cancer Management and Research)
Source: Cancer Management and Research - June 30, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway.
Abstract Postoperative cognitive dysfunction (POCD) is a common complication induced by anesthesia or surgery, which affects the concentration, cognition and memory of patients. Sevoflurane, a clinical anesthetic, could stimulate neuro-inflammation and lead to POCD. Recent studies found that specificity protein 1 (SP1) participates in the development of neurological diseases. Our study aims to elucidate the role of SP1 in sevoflurane-induced POCD pathogenesis. We anesthetized Sprague-Dawley rats and treated the primary hippocampal neurons with sevoflurane to construct the in vivo and in vitro POCD models. Besides,...
Source: Neurochemical Research - June 27, 2020 Category: Neuroscience Authors: Lv G, Li C, Wang W, Li N, Wang K Tags: Neurochem Res Source Type: research

General Anesthesia Maintained with Sevoflurane versus Propofol in Pediatric Surgery Shorter Than 1 Hour: A Randomized Single-Blind Study.
Authors: Wu G, Xu X, Fu G, Zhang P Abstract BACKGROUND Sevoflurane was compared with propofol for general anesthesia maintenance in pediatric operations lasting less than 1 hour in terms of anesthetic effect and postoperative recovery. MATERIAL AND METHODS Children scheduled for inguinal hernia repair or hydrocele testis repair were randomly assigned to receive general anesthesia maintained with either sevoflurane (n=43) or propofol (n=43). The ilioinguinal nerve was blocked with 1% lidocaine (7 mg/kg) after intravenous administration of ketamine (2 mg/kg). At the end of the surgery in patients receiving sevofluran...
Source: Medical Science Monitor - June 25, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sevoflurane as opposed to propofol anesthesia preserves mitochondrial function and alleviates myocardial ischemia/reperfusion injury
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Christopher Lotz, Jan Stumpner, Thorsten M. Smul (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 22, 2020 Category: Drugs & Pharmacology Source Type: research

Inhaled Anesthetic Agents
General anesthesia refers to a drug-induced loss of consciousness during which patients are not arousable, even by painful stimuli and often have impaired ventilatory function.1 Inhaled anesthetic gases can be administered to impart general anesthesia and are often administered adjunctively with intravenous sedatives (eg, propofol, fentanyl, midazolam) to maintain appropriate depths of anesthesia throughout the surgical case.2 Inhaled anesthetic agents include isoflurane, sevoflurane, desflurane, and nitrous oxide (N2O). (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - June 22, 2020 Category: Nursing Authors: Rachel C. Wolfe Tags: Pharmacology Facts Source Type: research

Randomized, double-blind, placebo-controlled study of the analgesic effect of intraoperative esmolol for laparoscopic gastroplasty.
CONCLUSION: Intraoperative esmolol promotes reductions in pain intensity and the need for analgesic supplementation without adverse effects, thus representing an effective drug for multimodal analgesia in gastroplasty. PMID: 32555939 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - June 21, 2020 Category: Surgery Authors: Morais VBD, Sakata RK, Huang APS, Ferraro LHDC Tags: Acta Cir Bras Source Type: research

Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice
Translational Psychiatry, Published online: 20 June 2020; doi:10.1038/s41398-020-00884-5Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice (Source: Translational Psychiatry)
Source: Translational Psychiatry - June 20, 2020 Category: Psychiatry Authors: Linghua Xie Yue Liu Yuhan Hu Bei Wang Zhirui Zhu Yilei Jiang Yaojun Suo Miaofeng Hu Jing Gao Rahim Ullah Zhiyong Hu Source Type: research

New Method of Destroying Waste Anesthetic Gases Using Gas-Phase Photochemistry.
on MS Abstract BACKGROUND: The inhalation anesthetics are potent greenhouse gases. To reduce the global environmental impact of the health care sector, technologies are sought to limit the release of waste anesthetic gas into the atmosphere. METHODS: Using a photochemical exhaust gas destruction system, removal efficiencies for nitrous oxide, desflurane, and sevoflurane were measured at various inlet concentrations (25% and 50%; 1.5%, 3.0%, and 6.0%; and 0.5%, 1.0%, and 2.0%, respectively) with flow rates ranging from 0.25 to 2.0 L/min. To evaluate the economic competitiveness of the anesthetic waste gas dest...
Source: Anesthesia and Analgesia - June 17, 2020 Category: Anesthesiology Authors: Rauchenwald V, Rollins MD, Ryan SM, Voronov A, Feiner JR, Šarka K, Johnson MS Tags: Anesth Analg Source Type: research

Combination of intramuscular alfaxalone, butorphanol, and midazolam as a novel immobilization protocol in 3 ring-tailed lemurs ( Lemur catta )
ConclusionsThe combination of intramuscular alfaxalone, butorphanol and midazolam provided a clinically useful sedation/immobilization in ring-tailed lemurs with only minor complications such as mild hypothermia, hypotension, hypoventilation and bradycardia. This protocol could be considered in ring-tailed lemurs that need to be immobilized for minor procedures, or as a pre-anaesthetic premedication, especially if a full pre-anaesthetic clinical exam is not possible. (Source: Irish Veterinary Journal)
Source: Irish Veterinary Journal - June 16, 2020 Category: Veterinary Research Source Type: research

Efficacy of 0.5 mg/kg of propofol at the end of anesthesia to reduce the incidence of emergence agitation in children undergoing general anesthesia with sevoflurane
Conclusion: Administration of 0.5 mg/kg of propofol at the end of anesthesia effectively reduces the incidence of EA in children undergoing general inhalational anesthesia with sevoflurane. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - June 15, 2020 Category: Anesthesiology Authors: Andi Ade Wijaya Ramlan Dimas K. Bonardo Pardede Arif H. M. S Marsaban Jefferson Hidayat Fildza Sasri Peddyandhari Source Type: research

Cost identification analysis of general anesthesia
Conclusion: Low flow anesthesia with isoflurane is more cost-effective as compared to high flow techniques and TIVA even for short duration surgeries. Rational use of drugs and consumables and minimizing wastage can further reduce anesthesia costs. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - June 15, 2020 Category: Anesthesiology Authors: Rohit Malhotra Nishant Kumar Aruna Jain Source Type: research

[Influence of methylprednisolone on the reversal time of sugammadex: a randomized clinical trial].
The objective of this study was to compare the recovery times of sugammadex for reversing rocuronium-induced moderate neuromuscular blockade in those who received intraoperative 1 mg.kg-1 methylprednisolone or saline. METHOD: This single-centered, randomized, controlled, prospective study included 162 adult patients undergoing elective ear-nose-throat procedures (aged from 18-65, an ASA physical status I-II, a BMI less than 30 kg.m-2, and not taking steroid drug medication) with propofol, remifentanyl, rocuronium and sevoflurane. Neuromuscular monitoring was performed using calibrated acceleromyography. The Control Gro...
Source: Revista Brasileira de Anestesiologia - June 14, 2020 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model
. (Source: Archives of Physiology and Biochemistry)
Source: Archives of Physiology and Biochemistry - June 13, 2020 Category: Physiology Authors: Hao Chen Yi Peng Li Wang Xin Wang Source Type: research

Comparison of 1-year recurrence-free survival between sevoflurane and propofol use for general anesthesia management in primary breast cancer surgery
ConclusionIn patients undergoing primary breast cancer surgery, the use of either sevoflurane or propofol without regional anesthesia did not appear to affect the risk of recurrence after 1  year. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - June 10, 2020 Category: Anesthesiology Source Type: research

Impact of Anesthesia on Long-term Outcomes in Patients With Supratentorial High-grade Glioma Undergoing Tumor Resection: A Retrospective Cohort Study
This study investigated 154 patients who received propofol and 140 patients who received sevoflurane for maintenance of anesthesia during HGG tumor resection. The primary outcomes were progression-free survival and overall survival. Results: Median progression-free survival was 10 months (interquartile range [IQR], 6 to 18) versus 11 months (IQR 6 to 20; P=0.674), and median overall survival was 18 months (IQR, 11 to 39) versus 18 months (IQR, 10 to 44; P=0.759) in patients maintained with propofol and sevoflurane, respectively. Higher preoperative Karnofsky performance status and postoperative chemotherapy were associa...
Source: Journal of Neurosurgical Anesthesiology - June 9, 2020 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Hypotension and Hypocapnia During General Anesthesia in Piglets: Study of S100b as an Acute Biomarker for Cerebral Tissue Injury
Conclusion: S100b did not increase following 60 minutes of systemic hypotension and/or hypocapnia during GA in piglets. In this setting, the use of S100b as a biomarker of cerebral cell tissue dysfunction cannot be supported. (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 9, 2020 Category: Anesthesiology Tags: Laboratory Investigation Source Type: research

Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas.
Abstract During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring's CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memor...
Source: Acta Biochimica et Biophysica Sinica - June 9, 2020 Category: Biochemistry Authors: Chen B, Liu Y, Cai Y, Tang D, Xu S, Gao P, Yu W, Jiao Y, Li W Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

AMPK-SIRT1-PGC1 α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia
AbstractTo understand the effect of AMP-activated protein kinase (AMPK)-SIRT1 (silent information regulator 1)-PPAR γ coactivator-1α (PGC1α) signaling pathway on the cognitive function of sevoflurane-anesthetized aged rats. Aged rats were divided into Normal group, Sevo group (Sevoflurane anesthesia), Sevo + AICAR (the AMPK activator) group, Sevo + EX527 group (the AMPK inhibitor), and Sevo + AICAR + EX527 gro up. The cognitive function of rats was determined by the Morris water maze. Hippocampal neuronal apoptosis was evaluated by TUNEL and Fluoro-Jade C (FJC) staining, and the expression of cleaved casp...
Source: Journal of Molecular Neuroscience - June 8, 2020 Category: Neuroscience Source Type: research

Use of Dexmedetomidine and Opioids as the Primary Anesthetic in Infants and Young Children: A Retrospective Cohort Study.
Abstract BACKGROUND: Anesthetic regimens using dexmedetomidine and short acting opioids have been suggested as potential alternatives to sevoflurane-based anesthesia in children. The primary aim of this study is to compare demographics, intraoperative characteristics, and complications of general anesthetics in which dexmedetomidine and opioids were used without sevoflurane, or in combination with a low sevoflurane concentration, in children 36 months old and younger. The secondary aim is to evaluate intraoperative bispectral index (BIS) values when available in these patients. METHODS: General anesthetics pe...
Source: Paediatric Anaesthesia - June 8, 2020 Category: Anesthesiology Authors: Efune PN, Longanecker JM, Alex G, Saynhalath R, Khan U, Rivera K, Jerome AP, Boone W, Szmuk P Tags: Paediatr Anaesth Source Type: research

Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage
Publication date: Available online 6 June 2020Source: Neuroscience LettersAuthor(s): Orhan Altay, Hidenori Suzuki, Bilge Nur Altay, Vahit Calisir, Jiping Tang, John H. Zhang (Source: Neuroscience Letters)
Source: Neuroscience Letters - June 7, 2020 Category: Neuroscience Source Type: research

A retrospective cohort study of adverse event assessment during anesthesia-related proceduresfor cochlear implant candidacy assessment and cochlear implantationin infants and toddlers.
CONCLUSIONS: Adverse events occur independent of the age at implantation,the number of anesthetic preoperative procedures and the type of anesthetic maintenance agent in patientswho received a cochlear implant before 24 months of age. PMID: 32506586 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - June 7, 2020 Category: Anesthesiology Authors: Bruijnzeel H, Wammes E, Stokroos RJ, Topsakal V, de Graaff JC Tags: Paediatr Anaesth Source Type: research

Sevoflurane inhibits migration and invasion of glioma cells via regulating miR-34a-5p/MMP-2 axis
Publication date: Available online 2 June 2020Source: Life SciencesAuthor(s): Huaping Zhao, Fei Xing, Jingjing Yuan, Zhisong Li, Wei Zhang (Source: Life Sciences)
Source: Life Sciences - June 5, 2020 Category: Biology Source Type: research

Sevoflurane impedes the progression of glioma through modulating the circular RNA has_circ_0012129/miR-761/TGIF2 axis.
CONCLUSIONS: Sevoflurane mediated the progression of glioma via regulating the circ_0012129/miR-761/TGIF2 axis. PMID: 32495888 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Remifentanil and sevoflurane based anesthesia combined with bilateral erector spinae plane block in patients undergoing off-pump coronary artery bypass graft surgery.
Conclusions: Remifentanil/sevoflurane anesthesia combined with bilateral ESP block shortens mechanical ventilation time and ICU stay, and decreases postoperative troponin-T concentration in patients undergoing off-pump coronary bypass graft surgery. PMID: 32489496 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Source: Videosurgery and Other Miniinvasive Techniques - June 4, 2020 Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies.
Abstract The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low intracellular heme oxygenase (HO-1), making them particularly vulnerable to the disease. Additionally, COVID-19's heme reduction may contribute to even lower HO-1. Low-grade inflammation associated with these risk factors contributes to triggering a cytokine storm that spreads to multi-organ failure and near death. The high mortality of those treated with ventilator ...
Source: Cell Stress and Chaperones - June 4, 2020 Category: Cytology Authors: Hooper PL Tags: Cell Stress Chaperones Source Type: research

Sevoflurane Preconditioning Confers Delayed Cardioprotection by Upregulating AMP-Activated Protein Kinase Levels to Restore Autophagic Flux in Ischemia-Reperfusion Rat Hearts.
CONCLUSIONS Sevoflurane exerts a delayed cardioprotective effects against myocardial injury in rats by activation of AMPK and restoration of I/R-impaired autophagic flux. PMID: 32476662 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 3, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Sevoflurane inhibits growth factor-induced angiogenesis through suppressing Rac1/paxillin/FAK and Ras/Akt/mTOR
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - June 1, 2020 Category: Cancer & Oncology Authors: Xuesong Wang Yao Yao Jin Gao Source Type: research

The Physiological Effect of 1MAC Sevoflurane with or without 50% Xenon in Immature Rats.
Abstract Anesthetic-induced neurodegenerationin rats occursacross the first three postnatal weeks1 (human equivalent:fetus to pre-schooler), during which the central nervous system, respiratory control and pharmacodynamics undergo hugechanges. In immature rats, hypercarbia alone(mimicking isoflurane anesthesia-induced hypercarbia) induced neurodegeneration2 and Xenon reducesanesthetic-induced neurodegeneration. PMID: 32476187 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - June 1, 2020 Category: Anesthesiology Authors: Bountra K, Gill H Tags: Paediatr Anaesth Source Type: research

Protective effects of Coenzyme Q10 against sevoflurane-induced cognitive impairment through regulating apolipoprotein E and phosphorylated Tau expression in young mice.
Abstract Children with multiple exposures to anesthesia and surgery may be more likely to develop learning disability. Coenzyme Q10 (CoQ10) was reported to reduce the multiple sevoflurane treatment induced cognitive deficiency in 6-day old young mice. However, its specific mechanisms have not yet been found. This research aimed to reveal the role of ApoE in the pathogenesis of cognitive deficiency caused by sevoflurane anesthesia and the protective mechanism of CoQ10 in a multiple sevoflurane treatment model of young mice. The mice were randomly divided into 4 groups: Control + corn oil, Sevoflurane + corn oil, Co...
Source: International Journal of Developmental Neuroscience - May 30, 2020 Category: Neuroscience Authors: Yang M, Tan H, Zhang K, Lian N, Yu Y, Yu Y Tags: Int J Dev Neurosci Source Type: research

Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.
Abstract Tetramethylpyrazine has shown neuroprotective and axonal outgrowth-promoting effects and can improve cognitive deficit in a rat model of chronic hypoperfusion. However, the role of tetramethylpyrazine in sevoflurane-induced neurotoxicity is still vague. Therefore, this study was designed to investigate the effects and mechanisms of tetramethylpyrazine on sevoflurane-induced autophagy, apoptosis, and the expression of BACE1 and A[Formula: see text] in SH-SY5Y cells. We measured the expression levels of the apoptosis protein markers Bax and Bcl-2, autophagy protein markers Atg5 and LC3-II, BACE1, and A[Form...
Source: The American Journal of Chinese Medicine - May 30, 2020 Category: Complementary Medicine Authors: Xu L, Shen J, Dai S, Sun L, Chen X Tags: Am J Chin Med Source Type: research

Optimization of Ultrasound Backscatter Spectroscopy to Assess Neurotoxic Effects of Anesthesia in the Newborn Non-human Primate Brain
Studies in animal models have revealed that long exposures to anesthetics can induce apoptosis in the newborn and young developing brain. These effects have not been confirmed in humans because of the lack of a non-invasive, practical in vivo imaging tool with the ability to detect these changes. Following the successful use of ultrasound backscatter spectroscopy (UBS) to monitor in vivo cell death in breast tumors, we aimed to use UBS to assess the neurotoxicity of the anesthetic sevoflurane (SEVO) in a non-human primate (NHP) model. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 28, 2020 Category: Radiology Authors: Laura Casta ñeda-Martinez, Kevin K. Noguchi, Chrysanthy Ikonomidou, James A. Zagzebski, Timothy J. Hall, Ivan M. Rosado-Mendez Tags: Original Contribution Source Type: research

Sevoflurane Consumption During Inhalational Induction in Children: A Randomized Comparison of Minute Ventilation-Based Techniques With Standard Fixed Fresh Gas Flow Technique.
This study was done to ascertain the optimum fresh gas flow (FGF) offering the best balance between rapid induction and minimal waste in pediatric patients. Forty-five children (weighing 10-20 kg) undergoing elective procedures under general anesthesia were randomly assigned into 3 groups: 0.5 minute ventilation (MV), MV, and S (FGF = 6 L/min). After priming the pediatric closed circuit, anesthesia was induced using a face mask with 8% sevoflurane in 100% oxygen (Draeger Primus Vista 120 anesthesia machine) at FGF-determined MV per group allocation. After loss of eyelash reflex (time 1 [T1]), intravenous cannulation (T2) a...
Source: AANA Journal - May 24, 2020 Category: Anesthesiology Authors: Gupta A, Datta PK Tags: AANA J Source Type: research

Sevoflurane attenuates cardiomyocyte apoptosis by mediating the miR-219a/AIM2/TLR4/MyD88 axis in myocardial ischemia/reperfusion injury in mice
. (Source: Cell Cycle)
Source: Cell Cycle - May 23, 2020 Category: Cytology Authors: Yan Li Na Xing Jingjing Yuan Jianjun Yang Source Type: research

Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways.
CONCLUSIONS: CTRP3 may effectively protect against sevoflurane-induced cognitive dysfunction and served as a potential predictive indicator and therapy target for POCD. PMID: 32432773 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Sevoflurane inhibits neuronal apoptosis and expressions of HIF-1 and HSP70 in brain tissues of rats with cerebral ischemia/reperfusion injury.
Authors: Yu F, Tong LJ, Cai DS Abstract OBJECTIVE: To observe the influences of sevoflurane on neuronal apoptosis and expressions of hypoxia-inducible factor 1 (HIF-1), and heat-shock protein 70 (HSP70) in brain tissues of rats with cerebral ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS: A total of 60 Sprague-Dawley rats were selected and divided into sham-operation group (Sham group, n=20), cerebral I/R model group (Model group, n=20), and 3% sevoflurane treatment group (Sevoflurane group, n=20). The rats in each group received neurological scoring, and the blood and brain tissues were collected to ...
Source: European Review for Medical and Pharmacological Sciences - May 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery
The glycocalyx layer is a key structure in the endothelium. Tourniquet-induced ischemic periods are used during orthopedic surgery, and the reactive oxygen species generated after ischemia-reperfusion may medi... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - May 20, 2020 Category: Anesthesiology Authors: Felipe Maldonado, Diego Morales, Rodrigo Guti érrez, Maximiliano Barahona, Oscar Cerda and Mónica Cáceres Tags: Research article Source Type: research

Sevoflurane versus PRopofol combined with Remifentanil anesthesia Impact on postoperative Neurologic function in supratentorial Gliomas (SPRING): protocol for a randomized controlled trial
Patients with intracranial tumors are more sensitive to anesthetics than the general population and are therefore more susceptible to postoperative neurologic and neurocognitive dysfunction. Sevoflurane or pro... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - May 19, 2020 Category: Anesthesiology Authors: Yan Xing, Nan Lin, Ruquan Han, John F. Bebawy, Yuming Peng, Jiaxin Li, Xiaoyuan Liu, Yan Li, Jia Dong, Min Zeng, Manyu Zhang and Lanyi Nie Tags: Study protocol Source Type: research

GSE135690 Impact of sevoflurane priming on B16F10 transcriptome after in vivo growth
Contributors : Dominik Schaack ; Isabella Sztwiertnia ; Florian UhleSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMurine skin melanoma cell line B16-F10 (ATCC no. CRL-6475) was obtained from the national standard repository (LGC Standards, Wesel, Germany). Priming of B16-F10 cells with sevoflurane was accomplished within a closed hypoxia chamber located in an 37 ºC heating cabinet. Cell flasks were put into the chamber and the chamber was flushed with 2% sevoflurane (Baxter, Unterschleissheim, Germany) in normal air with 21% O2 for 30min, followed by an incubation for additiona...
Source: GEO: Gene Expression Omnibus - May 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat
Publication date: Available online 12 May 2020Source: Neurotoxicology and TeratologyAuthor(s): Susan Burks, John Bowyer, Jennifer Walters, John Talpos (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 14, 2020 Category: Toxicology Source Type: research

Sevoflurane Enhances Proliferation, Metastatic Potential of Cervical Cancer Cells via the Histone Deacetylase 6 Modulation In Vitro
Background Sevoflurane is commonly used for cervical cancer surgery, but its effect on cervical cancer cell biology remains unclear. This mechanistic study explores how sevoflurane affects the proliferation and metastatic potential of immortalized cervical cancer cell lines.Methods Cultured cervical cancer Caski and HeLa lines were exposed to 1, 2, or 3% sevoflurane for 2 or 4  h. Cell proliferation was determined through the Kit-8 assay and Ki-67 immunofluorescent staining. Cell migration and invasion were evaluated with the Transwell assay. Immunofluorescent staining and Western blot analysis were used to identify...
Source: Anesthesiology - May 13, 2020 Category: Anesthesiology Source Type: research

Comparison of Cardioprotective Effects of Propofol versus Sevoflurane in Pediatric Living Donor Liver Transplantation.
Abstract BACKGROUND Our study compared the myocardiac protective effect of propofol vs. sevoflurane in pediatric patients receiving living donor liver transplantation (LDLT) surgery. MATERIAL AND METHODS We randomly and equally divided 120 children who underwent LDLT into a sevoflurane group and a propofol group. Preoperative, intraoperative, and postoperative data were collected and compared between the 2 groups. The concentrations of cTnI, CK-MB, IL-6, TNF-alpha, and HMGB1 at 5 min after induction (T0), 30 min in the anhepatic period (T1), and 3 h after reperfusion (T2), and at the end of surgery (T3) were measu...
Source: Annals of Transplantation - May 12, 2020 Category: Transplant Surgery Authors: Weng Y, Yuan S, Li H, Yu W Tags: Ann Transplant Source Type: research

Low-dose sevoflurane attenuates cardiopulmonary bypass (CPB)-induced postoperative cognitive dysfunction (POCD) by regulating hippocampus apoptosis via PI3K/AKT pathway.
CONCLUSION: Taken together, low-dose sevoflurane attenuated CPB-induced POCD by inhibiting hippocampus apoptosis through activating PI3K/AKT signal pathway. PMID: 32400333 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 12, 2020 Category: Neurology Authors: Qin J, Ma Q, Ma D Tags: Curr Neurovasc Res Source Type: research

A high concentration of sevoflurane induces gasping breaths in mice
Publication date: Available online 11 May 2020Source: Respiratory Physiology & NeurobiologyAuthor(s): Takashi Nishino, Hisayo Jin, Natsuko Nozaki-Taguchi, Shiroh Isono (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - May 11, 2020 Category: Respiratory Medicine Source Type: research

A subanesthetic dose of sevoflurane combined with oxygen exerts bactericidal effects and prevents lung injury through the nitric oxide pathway during sepsis
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Erfei Zhang, Xiaoying Zhao, Huihui MA, Dailei Luo, Yanjing Hu, Lichao Hou, Zhikai Luo (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 9, 2020 Category: Drugs & Pharmacology Source Type: research

Coenzyme Q10 alleviates sevoflurane ‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Mol Med Rep. 2020 May 05;: Authors: Yang M, Lian N, Yu Y, Wang Y, Xie K, Yu Y Abstract Sevoflurane may exert neurotoxic effects on the developing brain. Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia‑induced cognitive deficiency in 6‑day‑old mice. However, its specific mechanisms remain unknown. Apolipoprotein E (ApoE) has been reported to lead to the initiation of neurodegeneration in patients with Alzhe...
Source: Molecular Medicine Reports - May 8, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice
AbstractAutophagy, a crucial pathway for the degradation of proteins in eukaryotic cells, is linked to the development of Alzheimer ’s disease (AD), and the accumulated autophagosomes in the cells resulting in the death of cells. Sevoflurane can impair spatial learning and memory in mice with AD and lead to the apoptosis of nerve cells; however, the underlying mechanisms remain unknown. We aim to explore the effects and underl ying mechanisms of sevoflurane in APPswe/PS1ΔE9 double-transgenic mice. 51 heterozygous APPswe/PS1ΔE9 double-transgenic mice were involved and divided into three groups, including c...
Source: Acta Neurologica Belgica - May 8, 2020 Category: Neurology Source Type: research

A subanesthetic dose of sevoflurane combined with oxygen exerts bactericidal effects and prevents lung injury through the nitric oxide pathway during sepsis.
Abstract Volatile anesthetics have been proven to treat experimental sepsis. Sevoflurane combined with oxygen is widely applied in the clinic, and our previous study indicated that this regimen significantly reduced sepsis-induced inflammatory responses and that inhibition of NF-κB pathway activation may contribute to this protection effect. Furthermore, our previous data has shown that sevoflurane combined with oxygen has prevention effect on sepsis-induced lung injury properties and bactericidal properties, but the mechanism is not well understood. Nitric oxide (NO) has been shown to have bactericidal effe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 8, 2020 Category: Drugs & Pharmacology Authors: Zhang E, Zhao X, Ma H, Luo D, Hu Y, Hou L, Luo Z Tags: Biomed Pharmacother Source Type: research

Sevoflurane Induces Hippocampal Neuronal Apoptosis by Altering the Level of Neuropeptide Y in Neonatal Rats.
In this study, postnatal day 7 (PND7) Sprague-Dawley rats and primary cultured cells separated from hippocampi were exposed to sevoflurane (2.4% for 4 h) and the NPY expression levels after treatment were analyzed. Furthermore, neuronal apoptosis assay was conducted via immunofluorescence staining of cleaved caspase-3 and flow cytometry after exogenous NPY administration to PND7 rats as well as cultured hippocampal neurons to elucidate the role of NPY in sevoflurane-induced neurotoxicity. Our results showed the level of NPY gradually decreased within 24 h after sevoflurane exposure in both the hippocampus of PND7...
Source: Neurochemical Research - May 6, 2020 Category: Neuroscience Authors: Kang W, Lu D, Yang X, Ma W, Chen X, Chen K, Xu X, Zhou X, Zhou L, Feng X Tags: Neurochem Res Source Type: research

Neurotoxicity of sub-anesthetic doses of sevoflurane and dexmedetomidine co-administration in neonatal rats.
CONCLUSIONS: In the neonatal rat model, co-administration of a clinically relevant dose of DEX (1 µg/kg) with a sub-anesthetic dose of SEVO (1.1%) does not affect the neurotoxicity of the anesthetic while co-administration of higher doses of DEX with SEVO 1.1% potentiates it. PMID: 32387222 [PubMed - as supplied by publisher] (Source: Neurotoxicology)
Source: Neurotoxicology - May 5, 2020 Category: Neurology Authors: Perez-Zoghbi JF, Zhu W, Neudecker V, Grafe MR, Brambrink AM Tags: Neurotoxicology Source Type: research

Short or moderate-time exposure to the inhalational anesthetics isoflurane and sevoflurane does not alter the marble-burying behavior in mice
Publication date: Available online 1 May 2020Source: Neuroscience LettersAuthor(s): Tamires Gaigher Rocha, Cristina Luz Tosta, Letícia Santos Herbst, Vanessa Beijamini (Source: Neuroscience Letters)
Source: Neuroscience Letters - May 1, 2020 Category: Neuroscience Source Type: research