Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity
Sevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. H... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - June 19, 2019 Category: Anesthesiology Authors: Marianna Juh ász, Levente Molnár, Béla Fülesdi, Tamás Végh, Dénes Páll and Csilla Molnár Tags: Research article Source Type: research

Evidence for a conditioning effect of inhalational anesthetics on angiographic vasospasm after aneurysmal subarachnoid hemorrhage.
Abstract OBJECTIVE: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is characterized by large-artery vasospasm, distal autoregulatory dysfunction, cortical spreading depression, and microvessel thrombi. Large-artery vasospasm has been identified as an independent predictor of poor outcome in numerous studies. Recently, several animal studies have identified a strong protective role for inhalational anesthetics against secondary brain injury after SAH including DCI-a phenomenon referred to as anesthetic conditioning. The aim of the present study was to assess the potential role of inh...
Source: Journal of Neurosurgery - June 14, 2019 Category: Neurosurgery Authors: Athiraman U, Aum D, Vellimana AK, Osbun JW, Dhar R, Tempelhoff R, Zipfel GJ Tags: J Neurosurg Source Type: research

Comparison of bispectral index values and depth of sedation during deep sedation using sevoflurane anesthesia in healthy children versus children with cerebral palsy
Conclusion: We concluded that it is necessary to consider the dosage and effect mechanisms of drugs used in children with CP to prevent overuse of anesthetics and emergence of anesthesia-related complications. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - June 12, 2019 Category: Rural Health Authors: P Onal N Oztas G Kip Source Type: research

Effect of entropy-guided low-flow desflurane anaesthesia on laryngeal mask airway removal time in children undergoing elective ophthalmic surgery & #8211; A prospective, randomised, comparative study
Conclusion: Entropy-guided low-flow desflurane anaesthesia is associated with faster LMA removal and reduced consumption of desflurane in children undergoing ophthalmic surgery. (Source: Indian Journal of Anaesthesia)
Source: Indian Journal of Anaesthesia - June 11, 2019 Category: Anesthesiology Authors: Shivangi Mishra Renu Sinha Bikash Ranjan Ray Ravinder Kumar Pandey Vanlal Darlong Jyotsna Punj Source Type: research

Prolonged Anesthetic Recovery after Continuous Infusion of Midazolam in 2 Domestic Cats (Felis catus).
Abstract Two healthy research cats involved in a randomized, blinded prospective pharmacodynamics study evaluating midazolamcontinuous-rate infusion as a means to decrease sevoflurane concentrations experienced unexpectedly prolonged recoveries.Midazolam loading doses, infusion rates, and the targeted plasma midazolam concentrations at steady-state were determinedby pharmacokinetic modeling based on the results of a preliminary pharmacokinetic study using a single dose of midazolam. In the pharmacodynamics study, cats remained oversedated after recovery from anesthesia, and plasma concentrations of midazolam and i...
Source: Comparative Medicine - June 10, 2019 Category: Zoology Authors: Dholakia U, Seddighi R, Odunayo A, Cox SK, Jones EH, Pypendop BH Tags: Comp Med Source Type: research

Sevoflurane Well-Handled in Children Is Excellent, but in the Wrong Hands Can Be Life-Threatening.
Authors: Herrera Castro R PMID: 31164021 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - June 7, 2019 Category: Surgery Tags: J Invest Surg Source Type: research

Can desflurane be an alternative to sevoflurane in neuroanesthesia?
Authors: Lee S PMID: 31161758 [PubMed - in process] (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - June 5, 2019 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

Sevoflurane prevents miR-181a-induced cerebral ischemia/reperfusion injury
ConclusionSevo preconditioning protected against CIRI in vitro and in vivo possibly by inhibiting miR-181a and facilitating XIAP. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - June 5, 2019 Category: Biochemistry Source Type: research

Ephedrine and phenylephrine induce opposite changes in cerebral and paraspinal tissue oxygen saturation, measured with near-infrared spectroscopy: a randomized controlled trial
This study aims to assess the effect of PE and E on rScO2 and rSpsO2, measured with near-infrared spectroscopy. A randomized 4-treatment cross-over trial was designed in 28 patients under BIS-titrated anaesthesia with sevoflurane. If MAP decreased more than 20% from baseline, incremental doses of PE and/or E were given according to the randomization (group I: E –PE–E, group II: PE–E–PE, group III: E–E–E, group IV: PE–PE–PE). rScO2 and rSpsO2 on T3–T4, T9–T10 and L1–L2 were recorded. Differences in rSO2 (post-pretreatment) within each group were analyzed with...
Source: Journal of Clinical Monitoring and Computing - June 5, 2019 Category: Information Technology Source Type: research

Pulmonary Hypertension Manifesting as Atrial Arrhythmia in an Anesthetized Child; Diagnosis Using Focused Cardiac Ultrasound (FoCUS).
This article is protected by copyright. All rights reserved. PMID: 31166056 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - June 5, 2019 Category: Anesthesiology Authors: Boretsky KR, Casta A Tags: Paediatr Anaesth Source Type: research

Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain.
Abstract Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends from the third trimester of pregnancy to the third year of life. Despite all concerns, there is no ethically and medically acceptable alternative to the use of sedatives and anesthetics for surgeries and painful interventions. Development of measures that prevent injury while allowing the medications to exert their desired actions has enormous transla...
Source: Neurobiology of Disease - June 5, 2019 Category: Neurology Authors: Ikonomidou C, Kirvassilis G, Swiney BS, Wang SH, Huffman JN, Williams SL, Masuoka K, Capuano S, Brunner KR, Crosno K, Simmons HS, Mejia AF, Turski C, Brambrink A, Noguchi KK Tags: Neurobiol Dis Source Type: research

Neuroglobin protects offspring rats from neuronal damage induced by sevoflurane exposure to pregnant rats by inhibiting endogenous apoptosis.
Abstract As a general anesthesia drug, sevoflurane has been found to be potentially neurotoxic to the developing brain. Neuroglobin (Ngb) is a novel oxygen-carrying globulin that has been demonstrated to have neuroprotective effects in a variety of central nervous system disorders. However, it is unclear whether Ngb has a protective effect on nerve damage caused by sevoflurane. Therefore, this study was designed to investigate the effect and related mechanisms of Ngb on neural injury induced by sevoflurane. Pregnant rats on gestational day 20 (G20) were exposed to 3.5% sevoflurane for two hours, which led to an in...
Source: International Journal of Developmental Neuroscience - June 4, 2019 Category: Neuroscience Authors: Zhang Y, Yang F, Gao Y, Shan Y, Dong Y, Liu H Tags: Int J Dev Neurosci Source Type: research

Sevoflurane prevents miR-181a-induced cerebral ischemia/reperfusion injury.
CONCLUSION: Sevo preconditioning protected against CIRI in vitro and in vivo possibly by inhibiting miR-181a and facilitating XIAP. PMID: 31170386 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - June 3, 2019 Category: Molecular Biology Authors: Zhang Y, Shan Z, Zhao H, Ai Y Tags: Chem Biol Interact Source Type: research

Analyzing Electroencephalography (EEG) Waves Provides a Reliable Tool to Assess the Depth of Sevoflurane Anesthesia in Pediatric Patients.
Authors: Beekoo D, Yuan K, Dai S, Chen L, Di M, Wang S, Liu H, ShangGuan W Abstract BACKGROUND Studies have reported that BIS is unreliable in children because its algorithm provides misleading information about the actual depth of anesthesia. Raw EEG analysis provides direct neurophysiologic measurement of cerebral activity. The relationship between age and EEG has rarely been reported, thus the aim of the present study was to compare raw electroencephalography (EEG) among different age groups of surgical patients under general anesthesia with 1.0 MAC sevoflurane. MATERIAL AND METHODS We enrolled 135 patients aged...
Source: Medical Science Monitor - June 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The functional luminal imaging probe (FLIP) is a novel method to assess morphology and functional properties of the esophagus in patients with a wide array of esophageal pathologies. The assessment of esophageal body and esophagogastric junction (EGJ) distensibility index (DI) has particularly been promising for achalasia, eosinophilic esophagitis, and esophageal stricture. FLIP measurements are typically taken when the patient is sedated. However, sedation protocols differ between pediatric and adult populations and between institutions. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - June 1, 2019 Category: Gastroenterology Authors: Alain Benitez, Denis H. Jablonka, Varun Sahu, Craig Gluckman, Maureen DeMarshall, Svetlana Ostapenko, Gary W. Falk, Kristle L. Lynch, Calies D. Menard-Katcher, Amanda B. Muir Tags: Tuesday abstract Source Type: research

Little is known about best practices for combining specific inhalational anesthetics with propofol sedation for pediatric endoscopy. In particular, reports have described use of sevoflurane and nitrous oxide (N2O) -- in combination or individually – although other inhalational agents, as well as total intravenous anesthesia (TIVA), have also been suggested as reasonable approaches for the same procedures. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - June 1, 2019 Category: Gastroenterology Authors: Kayla T. Hartjes, John Barber, Jenifer R. Lightdale Tags: Saturday abstract Source Type: research

Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study.
CONCLUSION: Propofol seems to induce a higher postoperative fraction of the CD163highHLA-DRlow monocyte subset. This could represent either a compensatory mechanism dampening the higher inflammatory condition observed with Propofol at T2 or a consequence of a higher postoperative Propofol-induced hemolysis. PMID: 31151363 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - May 31, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Sbrana S, Nunziata A, Storti S, Haxhiademi D, Mazzone A, Leone M, Solinas M, Del Sarto P Tags: Perfusion Source Type: research

Midazolam prevents sevoflurane-induced death in hippocampal neurons.
In this study, we identified the neuroprotective role of midazolam in hippocampal neurons. Midazolam treatment could alleviate the neuronal death and promote the neuronal maturation in hippocampal neurons in vitro. In vivo studies demonstrated that midazolam injection could improve behavioral deficit in sevoflurane-exposed animals. The anti-apoptotic function of midazolam in sevoflurane-exposed neurons was mediated by ERK signaling. Collectively, we elucidated a new role of midazolam in preventing hippocampal neuronal death from sevoflurane exposure, potentially providing a new strategy to resist the neurotoxicity in the c...
Source: Tissue and Cell - May 29, 2019 Category: Cytology Authors: Yu D, Zhu Y, Cui C, Long R, Ma J Tags: Tissue Cell Source Type: research

Comparison between Epidural and Opioid Analgesia for Infants Undergoing Major Abdominal Surgery.
Abstract BACKGROUND: Epidural analgesia is considered optimal for postoperative pain management after major abdominal surgery. The potential to decrease anesthetic and opioid exposure is particularly desirable for infants, given their vulnerability to respiratory depression and concern for anesthetic neurotoxicity. We reviewed our experience with infants undergoing major abdominal surgery to determine if epidural catheter use decreased anesthetic and opioid exposure and improved postoperative analgesia. METHODS: This retrospective cohort study included infants (
Source: Paediatric Anaesthesia - May 29, 2019 Category: Anesthesiology Authors: Martin LD, Adams TL, Duling LC, Grigg EB, Bosenberg A, Onchiri F, Jimenez N Tags: Paediatr Anaesth Source Type: research

Role of Epigenetic Mechanisms in Transmitting the Effects of Neonatal Sevoflurane Exposure to the Next Generation of Male, but not Female, Rats
(Br J Anaesth. 2018;121:406–416) Neonatal anesthesia-induced abnormalities and their mechanisms are poorly understood, even in exposed animals. Some studies have shown that rats, especially male rats, develop behavioral deficiencies and exacerbated hypothalamic-pituitary adrenal responses to stress when exposed as neonates to anesthetic. Furthermore, recent studies suggest that these deleterious effects could be carried into the next generation via epigenetic mechanisms (noncoding RNAs, DNA methylation). There is a pressing need for further research, in order to establish safety guidelines for anesthesia in children...
Source: Obstetric Anesthesia Digest - May 22, 2019 Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research

Sevoflurane Inhalation Anesthesia for Uncooperative Pediatric Outpatients in the Treatment of Ankyloglossia: A Retrospective Study of 137 Cases.
Authors: Sun Q, Chen K Abstract BACKGROUND: To retrospectively assess the efficacy and safety of sevoflurane inhalation anesthesia for the treatment of ankyloglossia on uncooperative pediatric outpatients. METHODS: Pediatric patients with ankyloglossia (Degree 3 to Degree 5, coarse or thick) were enrolled in this retrospective analysis. The treatment of ankyloglossia was conducted with sevoflurane induction (8%) and maintenance (2%-3%) continuously with nasal cannula. Heart rate, respiratory rate, electrocardiogram, blood pressure, and peripheral blood oxygen saturation were monitored continuously during operat...
Source: Journal of Investigative Surgery - May 22, 2019 Category: Surgery Tags: J Invest Surg Source Type: research

Inhaled sevoflurane for ICU sedation in pediatrics: what is the safest approach?
Authors: Bratton SL, Ibsen LM Abstract PMID: 31106554 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - May 22, 2019 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion.
This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods: Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min durin...
Source: Gastroenterology Research and Practice - May 18, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Comparison of desflurane and sevoflurane on postoperative recovery quality after tonsillectomy and adenoidectomy in children.
Authors: Wu X, Shan C, Peng B, Shi X, Zhang F, Cao J Abstract Comparison of desflurane and sevoflurane on the postoperative recovery quality after tonsillectomy and adenoidectomy in children was carried out. A retrospective analysis was performed on the medical records of 165 children who underwent tonsil and adenoid radiofrequency ablation under low-temperature plasma and were admitted to the Xuzhou Children's Hospital, Xuzhou Medical University from February 2014 to May 2017. In total, 79 children with sevoflurane anesthesia were in the sevoflurane group, and 86 children with desflurane anesthesia in the desflura...
Source: Experimental and Therapeutic Medicine - May 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Protective effects of TRPV1 inhibition against sevoflurane-induced cell death
In this study, we assessed the role of transient receptor potential vanilloid 1 (TRPV1) in mediating sevoflurane activation and whether the TRPV1 antagonist could prevent anesthesia-induced cell death. Here, we demonstrated that the expression of TRPV1 was increased after sevoflurane treatment, and pretreatment with TRPV1 antagonist SB366791 could attenuate the effect of sevoflurane on TRPV1 expression. Moreover, the inhibition of TRPV1 could prevent sevoflurane-induced cell death. The findings of this study provide novel insights into the treatment of general anesthesia-induced developmental neurotoxicity and even cogniti...
Source: Neuroscience Letters - May 15, 2019 Category: Neuroscience Source Type: research

Changes in Whole Brain Dynamics and Connectivity Patterns during Sevoflurane- and Propofol-induced Unconsciousness Identified by Functional Magnetic Resonance Imaging
Editor ’s PerspectiveWhat We Already Know about This TopicThe extent to which alterations within specific brain networks impairs communication among networks remains unknownWhat This Article Tells Us That Is NewIn a volunteer functional magnetic resonance study, general anesthesia reduced activity within and among networksSpecific between-network connectivity is necessary for consciousnessBackground A key feature of the human brain is its capability to adapt flexibly to changing external stimuli. This capability can be eliminated by general anesthesia, a state characterized by unresponsiveness, amnesia, and (most lik...
Source: Anesthesiology - May 15, 2019 Category: Anesthesiology Source Type: research

Optimised reversal without train-of-four monitoring versus reversal using quantitative train-of-four monitoring: An equivalence study
Conclusion: An optimised reversal strategy without TOF monitoring is not equivalent to a reversal strategy based on quantitative TOF monitoring. TOF monitoring should be used whenever applicable, although neostigmine is optimised. (Source: Indian Journal of Anaesthesia)
Source: Indian Journal of Anaesthesia - May 13, 2019 Category: Anesthesiology Authors: Ardyan Wardhana Juni Kurniawaty Yusmein Uyun Source Type: research

[Emergence delirium following sevoflurane anesthesia in adults: prospective observational study].
CONCLUSIONS: The incidence of emergence delirium in adults after general anesthesia using sevoflurane is significant and has not been adequately reported. Modifiable risk factors need to be addressed to further reduce its incidence. PMID: 31076155 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - May 12, 2019 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Pharmacogenomics of sevoflurane: role in emergence delirium
Publication date: Available online 10 May 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Abhijit Nair (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - May 12, 2019 Category: Anesthesiology Source Type: research

Principal Factors Associated With Ketorolac-Refractory Pain Behavior After Pediatric Myringotomy and Pressure Equalization Tube Placement: A Retrospective Cohort Study.
Abstract BACKGROUND: Prophylactic analgesic administration reduces pain behavior after pediatric bilateral myringotomy and pressure equalization tube placement (BMT). We hypothesized that postoperative pain in children treated with intraoperative ketorolac would, among several exposures of interest, be strongly associated with ear condition. METHODS: We conducted a retrospective cohort study of healthy children (9 months to 7 years) who underwent BMT at the Children's Hospital of Philadelphia or its ambulatory surgery centers from 2013 to 2016. Anesthetic care included preoperative oral midazolam, sevoflurane...
Source: Anesthesia and Analgesia - May 9, 2019 Category: Anesthesiology Authors: Cook-Sather SD, Castella G, Zhang B, Mensinger JL, Galvez J, Wetmore RF Tags: Anesth Analg Source Type: research

Emergence delirium following sevoflurane anesthesia in adults: prospective observational study
ConclusionsThe incidence of emergence delirium in adults after general anesthesia using sevoflurane is significant and has not been adequately reported. Modifiable risk factors need to be addressed to further reduce its incidence.ResumoJustificativa e objetivosO delírio ao despertar após a anestesia geral com sevoflurano não tem sido relatado com frequência em adultos como nas crianças. Este estudo teve como objetivo determinar a incidência de delírio ao despertar em pacientes adultos submetidos à anestesia com sevoflurano como agente volátil e os provávei...
Source: Brazilian Journal of Anesthesiology - May 3, 2019 Category: Anesthesiology Source Type: research

Sevoflurane has postconditioning as well as preconditioning properties against hepatic warm ischemia –reperfusion injury in rats
ConclusionPostC and PreC by sevoflurane at a clinically applicable dose have equally protective effects against hepatic IR injury by increasing HO-1 expression. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - May 3, 2019 Category: Anesthesiology Source Type: research

AT1 Receptor Mediated Hypertensive Response to Ang II in the Nucleus Tractus Solitarii of Normotensive Rats Involves NO Dependent Local GABA Release
Conclusion: Our results suggest that the AT1R mediated hypertensive response to angiotensin II within the NTS in normotensive rats is GABA and NO dependent. Nitric oxide produced within the NTS tonically potentiates local GABA and glutamate release. Introduction The central nervous system network that regulates the level of sympathetic tone and, hence, blood pressure, is located in the brainstem and consists mainly of the rostral ventrolateral medulla (RVLM), the paraventricular nucleus (PVN) of the hypothalamus and the nucleus tractus solitarii (NTS) (Guyenet, 2006). It is well-established that the RVLM, the so-ca...
Source: Frontiers in Pharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Dorsal Penile Nerve Block via Perineal Approach, an Alternative to a Caudal Block for Pediatric Circumcision: A Randomized Controlled Trial.
Conclusions: The ultrasound-guided dorsal penile nerve block via perineal approach can basically act as a safe and effective alternative to the caudal block in pediatric patients undergoing circumcision surgeries. Clinical Trials identifier is ChiCTR-IPR-15006670. Protocol is available at http://www.chictr.org.cn/showproj.aspx?proj=11319. PMID: 31032356 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 1, 2019 Category: Research Authors: Wang X, Dong C, Beekoo D, Qian X, Li J, Shang-Guan WN, Jiang X Tags: Biomed Res Int Source Type: research

Parallel transverse uterine incisions combined with cell salvage minimized bleeding in a patient with pernicious placenta previa and an unexplained decrease in hemoglobin after transfusion of allogeneic red blood cells: A case report
We report an extremely rare case of PPP and PA complicated with anemia and an unexplained decrease in the hemoglobin (Hb) levels after transfusion of 3 units of allogeneic red blood cells. Diagnoses: The patient was diagnosed with unexplained anemia, and hemolysis resulting from donor red blood cell transfusion was suspected preoperatively. Interventions: To minimize blood loss for safety, a new operative technique, parallel transverse uterine incisions (PTUI) in CS (PTUI CS), was used under general anesthesia in this case. Inhaled volatile sevoflurane was used for uterine relaxation during PTUI. Cell salvage was als...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Cancers, Vol. 11, Pages 613: Effect of Perioperative Lidocaine, Propofol and Steroids on Pulmonary Metastasis in a Murine Model of Breast Cancer Surgery
In conclusion, in a murine model of breast cancer surgery during sevoflurane anaesthesia, propofol and lidocaine each decreased pulmonary metastasis, while methylprednisolone increased it. (Source: Cancers)
Source: Cancers - May 1, 2019 Category: Cancer & Oncology Authors: Freeman Crowley Foley Gallagher Iwasaki Ma Buggy Tags: Article Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
In this study, C57BL/6 and Tau KO mice were used. For Tau KO mice, Western blot results of anti-Tau protein specific antibodies showed that Tau KO mice had no positive bands at 50–55 kDa (Tau protein position), while C57BL/6 mice normally expressed Tau protein (Figure 1).FIGURE 1Figure 1 Tau knockout (KO) mice did not express Tau protein.The C57BL/6 mice exhibited depressive behaviors, including anxiety, anhedonia, and depression-like after CUMS, and ketamine treatment alleviated their depressive behavior. Tau KO mice did not exhibit depressive behavior after CUMS. After treatment with ketamine at the same dose, ther...
Source: Frontiers in Psychiatry - April 30, 2019 Category: Psychiatry Source Type: research

Effects of Remote Ischemic Preconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
This study aimed to evaluate effects of remote ischemic preconditioning (RIPC) on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery (OPCABG). Methods: Sixty-five patients scheduled for the OPCABG were randomly assigned to control (n = 32) or RIPC group (n = 33). All patients received general anesthesia. Before the surgical incision, RIPC was induced on an upper limb with repeated 5-min ischemia and 5-min reperfusion for four times. Blood samples were collected from right internal jugular vein. Plasma levels of IL-6, IL-8, IL-10, TNF-α, cTnT, HFABP, IMA, and MDA were detected at p...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Intra-operative Temperature Monitoring with Cutaneous Zero-Heat- Flux-Thermometry in Comparison with Oesophageal Temperature: a prospective study in paediatric population.
CONCLUSION: SpotOn revealed itself as accurate as an oesophageal temperature probe when estimating central core temperatures under ideal conditions and over a narrow range of temperatures. No adverse effects were observed with the use of the SpotOn sensor. This article is protected by copyright. All rights reserved. PMID: 31034706 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 29, 2019 Category: Anesthesiology Authors: Carvalho H, Najafi N, Poelaert J Tags: Paediatr Anaesth Source Type: research

Effects of Sevoflurane Pretreatment on Myocardial Ischemia-Reperfusion Injury Through the Akt/Hypoxia-Inducible Factor 1-alpha (HIF-1 α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway.
Effects of Sevoflurane Pretreatment on Myocardial Ischemia-Reperfusion Injury Through the Akt/Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway. Med Sci Monit. 2019 Apr 27;25:3100-3107 Authors: Dong J, Xu M, Zhang W, Che X Abstract BACKGROUND The aim of this study was to investigate the effects of sevoflurane (SEV) on myocardial ischemia/reperfusion (I/R) injury in rats and its mechanism. MATERIAL AND METHODS Sixty male Sprague-Dawley rats were randomly divided into 3 groups: Sham group (n=20), I/R group (n=20) and I/R+SEV group (n=20). The I/R ...
Source: Medical Science Monitor - April 28, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Use Profile of Magnesium Sulfate in Anesthesia in Brazil
Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical effects and a low incidence of adverse events when used at recommended doses. Introduction Magnesium is the fourth most common ion in the body, and it participates in several cellular processes, including protein synthesis, neuromuscular function and stability of nucleic acid, as well as regulating other electrolytes such as calcium and sodium. Magnesium acts as a cofactor in protein synthesis, neuromuscular function and stability and the function of nucleic acids. It is a component of adenosine 5-triph...
Source: Frontiers in Pharmacology - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Ultrasound optic nerve sheath diameter evaluation in patients undergoing robot-assisted laparoscopic pelvic surgery
AbstractFollowing the interesting reading of the article “A randomised trial to compare the increase in intracranial pressure as correlated with the optic nerve sheath diameter during propofol versus sevoflurane-maintained anesthesia in robot-assisted laparoscopic pelvic surgery”, the authors comment some aspects about ocular ultrasonography to measur e optic nerve sheath diameter as a tool to detect potential intracranial hypertension, pointing out the utility of Standardized A Scan technique for this purpose. (Source: Journal of Robotic Surgery)
Source: Journal of Robotic Surgery - April 26, 2019 Category: Surgery Source Type: research

A single-center experience of pediatric foreign-body aspiration: A retrospective 4-year case series
Conclusion: The main treatment for FBA is prevention. However, in patients applied with bronchoscopy for FBA, controlled ventilation and appropriate general anesthesia should be generally used. Early bronchoscopic intervention with safe anesthesia and controlled ventilation support will improve the success rates in FBA cases. (Source: Lung India)
Source: Lung India - April 24, 2019 Category: Respiratory Medicine Authors: Mustafa Erman Dorterler Osman Hakan Kocaman Tansel Gunendi Mehmet Emin Boleken Source Type: research

Airway management of Congenital Pulmonary Airway Malformation Resection in neonates and infants: A case cohort study.
CONCLUSIONS: From our institution cohort, one lung ventilation was more commonly used during thoracoscopic resections and was most commonly achieved with endobronchial intubation. Most patients were induced with inhalational anesthesia (sevoflurane), non-depolarizing neuromuscular blocker, and gentle positive pressure ventilation for intubation. This article is protected by copyright. All rights reserved. PMID: 31013391 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 23, 2019 Category: Anesthesiology Authors: Narayanasamy S, Adler E, Mahmoud M, Burkley M, Lim FY, Subramanyam R Tags: Paediatr Anaesth Source Type: research

Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice.
In this study, six-day-old C57BL/6 mice were pretreated with luteoline (30, 60 mg/kg) intraperitoneally for 30 min before exposed to 3% sevoflurane 6 h consecutively. We first examined the effects of luteoline on hippocampal neuron apoptosis, inflammation and oxidative stress 18 h post anesthesia. The spatial learning and memory performance was measured using Morris water maze test from postnatal day 31 to 38. The results showed that luteoline ameliorated neuronal apoptosis as evidenced by decrease of apoptotic cells, downregulation of the cleavage levels of caspase-3 and PRAP, and inactivation ...
Source: Acta Histochemica - April 18, 2019 Category: Biochemistry Authors: Wang Y, Wang C, Zhang Y, Wang G, Yang H Tags: Acta Histochem Source Type: research

Sevoflurane Promotes Regeneration of the Endothelial Glycocalyx by Upregulating Sialyltransferase
During ischemia-reperfusion injury, the endothelial glycocalyx is damaged by  oxidative stress-induced release of hydrogen peroxide, leading to decreased endothelium-dependent vasodilation. The regenerative effects of sevoflurane on the endothelial glycocalyx and endothelium-dependent vasodilation in oxidative stress remain unclear. Sialic acid, which is a component of the glycocalyx, plays a key role in antioxidant activity and is catalyzed by the sialyltransferase, ST6Gal-I. We hypothesized that ST6Gal-I is involved in the sevoflurane-induced promotion of endothelial glycocalyx restoration and endothelium-dependent ...
Source: Journal of Surgical Research - April 17, 2019 Category: Surgery Authors: Satoshi Kazuma, Yasuyuki Tokinaga, Motonobu Kimizuka, Ryu Azumaguchi, Kohsuke Hamada, Michiaki Yamakage Tags: Vascular Source Type: research

A prospective randomized double-blind study to compare the early recovery profiles of desflurane and sevoflurane in patients undergoing laparoscopic cholecystectomy
Conclusion: The time required for early recovery from anaesthesia, was significantly shorter in the Desflurane group compared to the Sevoflurane group. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - April 16, 2019 Category: Anesthesiology Authors: Gauri R Gangakhedkar Joseph N Monteiro Source Type: research

Investigation of possible aqueous phase formation during vaporization of sevoflurane
Conclusions: An increase in water concentration following vaporization of sevoflurane can only occur when the starting water content is higher than the azeotropic concentration and therefore cannot originate from the dissolved water present in the marketed product because the water concentration in Ultane®is 34 times lower than the azeotropic concentration. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - April 16, 2019 Category: Anesthesiology Authors: Shane Varughese Vikram G Kalthod James P Petzel Hans Peter Bacher Arthur W Wallace Source Type: research

Monitoring the level of hypnosis using a hierarchical SVM system
AbstractMonitoring level of hypnosis is a major ongoing challenge for anesthetists to reduce anesthetic drug consumption, avoiding intraoperative awareness and prolonged recovery. This paper proposes a novel automated method for accurate assessing of the level of hypnosis with sevoflurane in 17 patients using the electroencephalogram signal. In this method, a set of distinctive features and a hierarchical classification structure based on support vector machine (SVM) methods, is proposed to discriminate the four levels of anesthesia (awake, light, general and deep states). The first stage of the hierarchical SVM structure ...
Source: Journal of Clinical Monitoring and Computing - April 15, 2019 Category: Information Technology Source Type: research

Sevoflurane induces temporary spatial working memory deficits and synaptic ultrastructure impairments in the hippocampus of neonatal rats.
CONCLUSIONS: We showed that a single sevoflurane exposure to neonatal rats led to temporary spatial working memory deficits. It might be associated with synaptic ultrastructure impairments in the CA3 region of the hippocampus, including fewer numbers of synapses, thinner thickness of PSD and broader synaptic cleft width. Fortunately, all the neurotoxicity and neurocognitive deficits were reversible. PMID: 30964191 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 11, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research