Sevoflurane
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Retracted: Mechanism of Sevoflurane Anesthesia under Hypothermic Cardiopulmonary Bypass on Postoperative Atrial Fibrillation Rhythm in Patients Undergoing Mitral Valve Replacement
Biomed Res Int. 2024 Mar 20;2024:9869156. doi: 10.1155/2024/9869156. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2022/5312897.].PMID:38550200 | PMC:PMC10977316 | DOI:10.1155/2024/9869156 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Retracted: Mechanism of Sevoflurane Anesthesia under Hypothermic Cardiopulmonary Bypass on Postoperative Atrial Fibrillation Rhythm in Patients Undergoing Mitral Valve Replacement
Biomed Res Int. 2024 Mar 20;2024:9869156. doi: 10.1155/2024/9869156. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2022/5312897.].PMID:38550200 | PMC:PMC10977316 | DOI:10.1155/2024/9869156 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Sevoflurane Exposure Induces Neuronal Cell Ferroptosis Initiated by Increase of Intracellular Hydrogen Peroxide in the Developing Brain via ER Stress ATF3 Activation
AbstractNeuronal cell death is acknowledged as the primary pathological basis underlying developmental neurotoxicity in response to sevoflurane exposure, but the exact mechanism remains unclear. Ferroptosis is a form of programmed cell death characterized by iron-dependent lipid peroxidation that is driven by hydrogen peroxide (H2O2) and ferrous iron through the Fenton reaction and participates in the pathogenesis of multiple neurological diseases. As stress response factor, activating transcription factor 3 (ATF3) can be activated by the PERK/ATF4 pathway during endoplasmic reticulum (ER) stress, followed by increased int...
Source: Molecular Neurobiology - March 27, 2024 Category: Neurology Source Type: research
Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial
This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from C... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - March 27, 2024 Category: Intensive Care Authors: Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina D übendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D. Krüger, Thomas A. Neff and Martin Schläpfer Tags: Research Source Type: research
Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice
CONCLUSIONS: Our findings suggest that hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice.PMID:38527593 | DOI:10.1016/j.bbadis.2024.167137 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 25, 2024 Category: Biochemistry Authors: Qi-Cheng Lin Jiao Wang Xin-Lin Wang Chi Pan Shao-Wu Jin Steven Char Yuan-Xiang Tao Hong Cao Jun Li Source Type: research
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
CONCLUSIONS: These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.PMID:38507523 | DOI:10.1213/ANE.0000000000006941 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Jia Yan Hoai Ton Jing Yan Yuanlin Dong Zhongcong Xie Hong Jiang Source Type: research
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
CONCLUSIONS: These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.PMID:38507523 | DOI:10.1213/ANE.0000000000006941 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Jia Yan Hoai Ton Jing Yan Yuanlin Dong Zhongcong Xie Hong Jiang Source Type: research
Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
CONCLUSION: Sevoflurane elicits a surge in Fgf2 expression in aging rats, directing tau protein phosphorylation through the PI3K/AKT/Gsk3b route, instigating cognitive aberrations.PMID:38493090 | DOI:10.1186/s10020-024-00784-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2024 Category: Molecular Biology Authors: Xin Xie Xiaomin Zhang Songze Li Wei Du Source Type: research
Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures
CONCLUSION: We have demonstrated that repeated neonatal sevoflurane exposures decreased inhibitory synaptic inputs (labelled by vGAT) around neurons, which may influence the upregulation of NL1 in hippocampal excitatory synapses and enhanced NL1/PSD95 interaction, ultimately leading to long-term cognitive impairments in adolescent rats. Injecting NL1--AAV reversed this damage. These results suggested that NL1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures.PMID:38493982 | DOI:10.1016/j.expneurol.2024.114755 (Source: Experimental Neurology)
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Hui Zhang Yingqiao Niu Peng Yuan Wenbo Liu Wei Zhu Jie Sun Source Type: research
Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
CONCLUSION: Sevoflurane elicits a surge in Fgf2 expression in aging rats, directing tau protein phosphorylation through the PI3K/AKT/Gsk3b route, instigating cognitive aberrations.PMID:38493090 | DOI:10.1186/s10020-024-00784-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2024 Category: Molecular Biology Authors: Xin Xie Xiaomin Zhang Songze Li Wei Du Source Type: research
Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures
CONCLUSION: We have demonstrated that repeated neonatal sevoflurane exposures decreased inhibitory synaptic inputs (labelled by vGAT) around neurons, which may influence the upregulation of NL1 in hippocampal excitatory synapses and enhanced NL1/PSD95 interaction, ultimately leading to long-term cognitive impairments in adolescent rats. Injecting NL1--AAV reversed this damage. These results suggested that NL1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures.PMID:38493982 | DOI:10.1016/j.expneurol.2024.114755 (Source: Experimental Neurology)
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Hui Zhang Yingqiao Niu Peng Yuan Wenbo Liu Wei Zhu Jie Sun Source Type: research
Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures
CONCLUSION: We have demonstrated that repeated neonatal sevoflurane exposures decreased inhibitory synaptic inputs (labelled by vGAT) around neurons, which may influence the upregulation of NL1 in hippocampal excitatory synapses and enhanced NL1/PSD95 interaction, ultimately leading to long-term cognitive impairments in adolescent rats. Injecting NL1--AAV reversed this damage. These results suggested that NL1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures.PMID:38493982 | DOI:10.1016/j.expneurol.2024.114755 (Source: Experimental Neurology)
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Hui Zhang Yingqiao Niu Peng Yuan Wenbo Liu Wei Zhu Jie Sun Source Type: research
Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures
CONCLUSION: We have demonstrated that repeated neonatal sevoflurane exposures decreased inhibitory synaptic inputs (labelled by vGAT) around neurons, which may influence the upregulation of NL1 in hippocampal excitatory synapses and enhanced NL1/PSD95 interaction, ultimately leading to long-term cognitive impairments in adolescent rats. Injecting NL1--AAV reversed this damage. These results suggested that NL1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures.PMID:38493982 | DOI:10.1016/j.expneurol.2024.114755 (Source: Experimental Neurology)
Source: Experimental Neurology - March 17, 2024 Category: Neurology Authors: Hui Zhang Yingqiao Niu Peng Yuan Wenbo Liu Wei Zhu Jie Sun Source Type: research
Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia
CONCLUSION: This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.PMID:38488453 | DOI:10.1111/cns.14675 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2024 Category: Neuroscience Authors: Fuyang Cao Yongxin Guo Shuting Guo Xinyu Hao Lujia Yang Jiangbei Cao Zhikang Zhou Weidong Mi Li Tong Source Type: research
