A Study in Two Panels of Healthy Adult Participants to Assess Single-Dose Immediate-Release and Single-Dose Dispersible Formulations of Pretomanid
Condition:   Multi-drug Resistant Tuberculosis Intervention:   Drug: Pretomanid Sponsor:   Global Alliance for TB Drug Development Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 16, 2020 Category: Research Source Type: clinical trials

Xpert Active Case-finding Trial 3 (XACT-3)
Condition:   Tuberculosis Interventions:   Other: GeneXpert Edge;   Other: GeneXpert Ultra Sponsors:   University of Cape Town;   Zambart (University of Zambia), Zambia;   Instituto Nacional de Saúde, Mozambique;   Biomedical Research and Training Institute, Zimbabwe;   Radboud University;   London School of Hygiene and Tropical Medicine;   University of Cape Town Lun g Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 10, 2020 Category: Research Source Type: clinical trials

Male Partner-assisted Contact Tracing for HIV and Tuberculosis in Malawi
Condition:   Tuberculosis Interventions:   Other: Access to Fast Track TB clinic;   Other: Information leaflet for male partner;   Other: Home sputum collection;   Other: Home HIV testing;   Other: Financial incentive Sponsors:   Liverpool School of Tropical Medicine;   Malawi-Liverpool-Wellcome Trust Clinical Research Programme;   London School of Hygiene and Tropical Medicine;   University of Liverpool Not yet recruitin...
Source: ClinicalTrials.gov - February 26, 2020 Category: Research Source Type: clinical trials

Effect of community active case-finding strategies for detection of tuberculosis in Cambodia: study protocol for a pragmatic cluster randomized controlled trial
This study will build an evidence base to inform future scale-up, implementation, and sustainability of ACF strategies in Cambodia and other similar settings. Implementation of this study will also complement TB control strategies in Cambodia by conducting ACF in operational districts without active interventions to find TB cases currently. Those who are ill and might have TB will be promptly screened, diagnosed, and linked to care. Early diagnosis and treatment initiation will also benefit their community by interrupting transmission and prevent further infections. The experience gained from this project will inform futur...
Source: Trials - February 23, 2020 Category: Research Source Type: clinical trials

Immunological Biomarkers in Tuberculosis Management
Conditions:   Tuberculosis;   Tuberculosis Infection Interventions:   Other: Multiple blood samples;   Other: Single blood sample Sponsor:   Hospices Civils de Lyon Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 17, 2020 Category: Research Source Type: clinical trials

Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label, phase II clinical trial (SAEFRIF)
This study aims to determine the safety of higher doses of rifampicin and its effect on the pharmacokinetics of efavirenz (EFV) and dolutegravir (DTG) in TB-HIV co-infected patients.MethodsThis study is a randomized, open-label, phase IIb clinical trial among TB-HIV infected adult outpatients attending an HIV clinic in Kampala, Uganda. Patients newly diagnosed with TB will be randomized to either standard-dose or high-dose rifampicin (35  mg/kg) alongside standard TB treatment. ART-naïve patients will be randomly assigned to first-line ART regimens (DTG or EFV). Those who are already on ART (DTG or EFV) at enro...
Source: Trials - February 12, 2020 Category: Research Source Type: clinical trials

Promoting Overall Care and Management Related to Tuberculosis Infection Through Pharmaceutical Care and Text Messaging
Condition:   Pulmonary TB Intervention:   Behavioral: New management mode Sponsors:   Farman Ullah Khan;   Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan;   Pakistan Institute of Medical Sciences;   Quaid i Azam University Islamabad Pakistan Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 11, 2020 Category: Research Source Type: clinical trials