Test evaluation trials present different challenges for trial managers compared to intervention trials
ConclusionWe present 10 common themes, including 31 challenges, in test evaluation trials that will be helpful to others designing and managing future test evaluation trials. Proactive identification of potential challenges at the design and planning stages of test evaluation trials will enable strategies to improve trial design and management that may be different from standard strategies used for intervention trials. Future work could extend this topic to include challenges for other trial stakeholders including participants, clinicians, statisticians and funders.Trial registrationAll trials reviewed in this project were...
Source: Trials - November 30, 2020 Category: Research Source Type: clinical trials

Comorbidities and Coinfections in Latent TB
Conditions:   Latent Tuberculosis;   Diabete Mellitus;   Malnutrition;   Helminth Infection Intervention:   Sponsors:   Tuberculosis Research Centre, India;   National Institutes of Health (NIH) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 24, 2020 Category: Research Source Type: clinical trials

Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTB
Condition:   Tuberculosis Interventions:   Drug: Meropenem Injection;   Drug: Amoxicillin Clavulanate;   Drug: Pyrazinamide;   Drug: Bedaquiline;   Drug: Rifafour Sponsor:   TASK Applied Science Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 16, 2020 Category: Research Source Type: clinical trials

Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Condition:   Refractory Proliferative Tubercular Arachnoiditis Intervention:   Drug: Cyclophosphamide injection Sponsor:   All India Institute of Medical Sciences, New Delhi Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2020 Category: Research Source Type: clinical trials

Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Conditions:   Tuberculosis;   Tubercular Meningitis;   Arachnoiditis; Tuberculous (Etiology) Intervention:   Drug: Cyclophosphamide injection Sponsor:   All India Institute of Medical Sciences, New Delhi Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2020 Category: Research Source Type: clinical trials

Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa
Conditions:   Tuberculosis;   HIV I Infection;   Sepsis Interventions:   Other: Immediate anti-TB therapy;   Other: Sepsis-specific dose anti-TB therapy Sponsors:   University of Virginia;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 5, 2020 Category: Research Source Type: clinical trials