Myelomeningocele: Long-Term Neurosurgical Management
Adv Tech Stand Neurosurg. 2024;49:95-122. doi: 10.1007/978-3-031-42398-7_6.ABSTRACTOpen spina bifida, also known as myelomeningocele (MMC), is the most challenging and severe birth defect of the central nervous system compatible with life and it is due to a failure in the dorsal fusion of the nascent neural tube during embryonic development. MMC is often accompanied by a constellation of collateral conditions, including hydrocephalus, Arnold - Chiari II malformation, brainstem disfunction, hydrosyringomyelia, tethered cord syndrome and scoliosis. Beyond early surgical repair of the dorsal defect, MMC requires lifelong care...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: E Marcati G Meccariello L Mastino M Picano P D Giorgi G Talamonti Source Type: research
Raman Spectroscopy Analysis of Human Amniotic Fluid Cells from fetuses with Myelomeningocele
Exp Cell Res. 2024 Apr 30:114048. doi: 10.1016/j.yexcr.2024.114048. Online ahead of print.ABSTRACTPrenatal surgery for the treatment of spina bifida (myelomeningocele, MMC) significantly enhances the neurological prognosis of the patient. To ensure better protection of the spinal cord by large defects, the application of skin grafts produced with cells gained from the amniotic fluid is presently studied. In order to determine the most appropriate cells for this purpose, we tried to shed light on the extremely complex amniotic fluid cellular composition in healthy and MMC pregnancies. We exploited the potential of micro-Ram...
Source: Experimental Cell Research - May 2, 2024 Category: Cytology Authors: Luca Pontiggia Katarzyna Michalak-Micka Nadine H ürlimann Hesham K Yosef Roland B öni Agnes S Klar Martin Ehrbar Nicole Ochsenbein-K ölble Thomas Biedermann Ueli Moehrlen Source Type: research
Raman Spectroscopy Analysis of Human Amniotic Fluid Cells from fetuses with Myelomeningocele
Exp Cell Res. 2024 Apr 30:114048. doi: 10.1016/j.yexcr.2024.114048. Online ahead of print.ABSTRACTPrenatal surgery for the treatment of spina bifida (myelomeningocele, MMC) significantly enhances the neurological prognosis of the patient. To ensure better protection of the spinal cord by large defects, the application of skin grafts produced with cells gained from the amniotic fluid is presently studied. In order to determine the most appropriate cells for this purpose, we tried to shed light on the extremely complex amniotic fluid cellular composition in healthy and MMC pregnancies. We exploited the potential of micro-Ram...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Luca Pontiggia Katarzyna Michalak-Micka Nadine H ürlimann Hesham K Yosef Roland B öni Agnes S Klar Martin Ehrbar Nicole Ochsenbein-K ölble Thomas Biedermann Ueli Moehrlen Source Type: research
Raman Spectroscopy Analysis of Human Amniotic Fluid Cells from fetuses with Myelomeningocele
Exp Cell Res. 2024 Apr 30:114048. doi: 10.1016/j.yexcr.2024.114048. Online ahead of print.ABSTRACTPrenatal surgery for the treatment of spina bifida (myelomeningocele, MMC) significantly enhances the neurological prognosis of the patient. To ensure better protection of the spinal cord by large defects, the application of skin grafts produced with cells gained from the amniotic fluid is presently studied. In order to determine the most appropriate cells for this purpose, we tried to shed light on the extremely complex amniotic fluid cellular composition in healthy and MMC pregnancies. We exploited the potential of micro-Ram...
Source: Experimental Cell Research - May 2, 2024 Category: Cytology Authors: Luca Pontiggia Katarzyna Michalak-Micka Nadine H ürlimann Hesham K Yosef Roland B öni Agnes S Klar Martin Ehrbar Nicole Ochsenbein-K ölble Thomas Biedermann Ueli Moehrlen Source Type: research
Raman Spectroscopy Analysis of Human Amniotic Fluid Cells from fetuses with Myelomeningocele
Exp Cell Res. 2024 Apr 30:114048. doi: 10.1016/j.yexcr.2024.114048. Online ahead of print.ABSTRACTPrenatal surgery for the treatment of spina bifida (myelomeningocele, MMC) significantly enhances the neurological prognosis of the patient. To ensure better protection of the spinal cord by large defects, the application of skin grafts produced with cells gained from the amniotic fluid is presently studied. In order to determine the most appropriate cells for this purpose, we tried to shed light on the extremely complex amniotic fluid cellular composition in healthy and MMC pregnancies. We exploited the potential of micro-Ram...
Source: Experimental Cell Research - May 2, 2024 Category: Cytology Authors: Luca Pontiggia Katarzyna Michalak-Micka Nadine H ürlimann Hesham K Yosef Roland B öni Agnes S Klar Martin Ehrbar Nicole Ochsenbein-K ölble Thomas Biedermann Ueli Moehrlen Source Type: research
Sleep-related breathing disorders in infants with spina bifida repaired prenatally and postnatally
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 25, 2024 Category: Sleep Medicine Authors: Katherine G. Stark
Rachel Y. Wang
Kathryn A. Smith
Jason Chu
Thomas G. Keens
Alexander Van Speybroeck
Ramen H. Chmait
Sally L. Davidson Ward
Iris A. Perez
1Neuroscience, Dornsife College of Letters Arts and Science University of Southern California, Los A Source Type: research
"Pressure kills kidneys": protection of the upper urinary tract through neuro-urological management
This article is intended to provide information about the epidemiology and complex pathogenetic mechanisms as well as the necessary diagnostic steps. Various medical, interventional and surgical treatment strategies are evaluated on the basis of current scientific findings, thus supporting the reader in the care of this complex patient group.PMID:38653468 | DOI:10.1055/a-2287-4933 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - April 23, 2024 Category: Urology & Nephrology Authors: Fabian Quei ßert Andres Jan Schrader Source Type: research
"Pressure kills kidneys": protection of the upper urinary tract through neuro-urological management
This article is intended to provide information about the epidemiology and complex pathogenetic mechanisms as well as the necessary diagnostic steps. Various medical, interventional and surgical treatment strategies are evaluated on the basis of current scientific findings, thus supporting the reader in the care of this complex patient group.PMID:38653468 | DOI:10.1055/a-2287-4933 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - April 23, 2024 Category: Urology & Nephrology Authors: Fabian Quei ßert Andres Jan Schrader Source Type: research
Commentary to “Accuracy in reporting incontinence in adults with spina bifida: a pilot study”
Comprehending the true impact of incontinence on quality of life would be an invaluable tool in the pediatric urologist ’s toolkit when counseling patients and families on potential interventions and for stratifying severity of symptoms. Often the confluence of objectivity and subjectivity belies the “true” nature of something so personal as “bother.” Here, the authors attempted to determine how immediate r ecall of bother secondary to urinary or fecal incontinence in the spina bifida (SB) population compared to a daily diary chronicling episodes of incontinence1. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - April 20, 2024 Category: Urology & Nephrology Authors: Hersh Trivedi, Hans C. Arora Source Type: research
Immunohistochemical and Histopathological Characterization of Spina Bifida Defect Tissues Removed After Prenatal and Postnatal Surgical Repair
Conclusion: Tissues harvested from prenatal and postnatal spina bifida repair surgeries appear as normal skin near the defect site. However, cystic tissues consist of highly dense fibrous connective tissue with complete absence of normal epidermal development.PMID:38634787 | DOI:10.1080/15513815.2024.2326834 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - April 18, 2024 Category: Pathology Authors: James R Bardill Melissa R Laughter Jaclyn B Anderson Hilary Hoffman Ahmed Gilani Maranke I Koster Ahmed I Marwan Source Type: research
Multicenter evaluation of complex urinary diversion for renal transplantation: outcomes of complex surgical solutions
ConclusionThe mid-term kidney transplant function with complex urinary diversion appears to be comparable to transplants with regular urinary diversions. Hence, complex urinary diversion should always be considered as a surgical option, even during transplantation, if necessary. (Source: World Journal of Urology)
Source: World Journal of Urology - April 17, 2024 Category: Urology & Nephrology Source Type: research
DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects
Arch Biochem Biophys. 2024 Apr 15;755:109991. doi: 10.1016/j.abb.2024.109991. Online ahead of print.ABSTRACTRegulation of nucleotide biosynthesis is necessary for maintaining cellular processes including DNA replication and repair. A key enzyme in this process is deoxythymidylate kinase (dTYMK), which catalyzes the initial step in the production of dTTP from dTMP. This gene constitutes the first merged step of dTTP synthesis from the de novo and salvage pathways which regulate dTMP biosynthesis. Decreased de novo dTMP biosynthesis causes dysregulated dTTP:dUTP pools, and leads to increased uracil in DNA and neural tube clo...
Source: Archives of Biochemistry and Biophysics - April 15, 2024 Category: Biochemistry Authors: Kendra A Tiani Patrick J Stover Source Type: research
