CAD1 contributes to osmotic tolerance in Arabidopsis thaliana by suppressing immune responses under osmotic stress
Biochem Biophys Res Commun. 2024 May 3;717:150049. doi: 10.1016/j.bbrc.2024.150049. Online ahead of print.ABSTRACTAcquired osmotolerance induced by initial exposure to mild salt stress is widespread across Arabidopsis thaliana ecotypes, but the mechanism underlying it remains poorly understood. To clarify it, we isolated acquired osmotolerance-deficient 1 (aod1), a mutant highly sensitive to osmotic stress, from ion-beam-irradiated seeds of Zu-0, an ecotype known for its remarkably high osmotolerance. Aod1 showed growth inhibition with spotted necrotic lesions on the rosette leaves under normal growth conditions on soil. H...
Source: Biochemical and Biophysical Research communications - May 7, 2024 Category: Biochemistry Authors: Yusuke Murakoshi Yasutaka Saso Minamo Matsumoto Kazuha Yamanaka Izumi Yotsui Yoichi Sakata Teruaki Taji Source Type: research
A two-step electrochemical method for separating Mg(OH) < sub > 2 < /sub > and CaCO < sub > 3 < /sub > : Application to RO reject and polluted groundwater
This study proposes a two-step electrochemical approach that separately recovers Ca2+ as CaCO3 and Mg2+ as Mg(OH)2. The first step uses an undivided cell with 3D electrodes and controlled flow directions to selectively precipitate CaCO3 on the electrode, keeping the cell removal efficiency. The second step employs a two-compartment cell with a cationic exchange membrane to recover Mg(OH)2. This approach was evaluated on RO reject water with high Ca2+ to Mg2+ ratio and industrial effluent-polluted groundwater with a low ratio. Treatment of domestic RO reject water using undivided cell specifically recovered 64% of CaCO3, al...
Source: Chemosphere - May 7, 2024 Category: Chemistry Authors: Manikandan Santhanam Rajeswari Selvaraj Maruthamuthu Sundaram Source Type: research
A two-step electrochemical method for separating Mg(OH) < sub > 2 < /sub > and CaCO < sub > 3 < /sub > : Application to RO reject and polluted groundwater
This study proposes a two-step electrochemical approach that separately recovers Ca2+ as CaCO3 and Mg2+ as Mg(OH)2. The first step uses an undivided cell with 3D electrodes and controlled flow directions to selectively precipitate CaCO3 on the electrode, keeping the cell removal efficiency. The second step employs a two-compartment cell with a cationic exchange membrane to recover Mg(OH)2. This approach was evaluated on RO reject water with high Ca2+ to Mg2+ ratio and industrial effluent-polluted groundwater with a low ratio. Treatment of domestic RO reject water using undivided cell specifically recovered 64% of CaCO3, al...
Source: Chemosphere - May 7, 2024 Category: Chemistry Authors: Manikandan Santhanam Rajeswari Selvaraj Maruthamuthu Sundaram Source Type: research
Cuproptosis is involved in decabromodiphenyl ether-induced ovarian dysfunction and the protective effect of melatonin
This study aimed to investigate the toxic effects of BDE-209 on the ovary and tried to improve ovarian function with melatonin. Herein, BDE-209 was administered orally to female SD rats for 60 days. Enzyme-linked immunosorbent assay, HE staining, transcriptome analysis, qPCR and immunohistochemical staining were used to explore and verify the potential mechanism. We found that BDE-209 exposure had effects on the ovary, as shown by abnormal changes in the estrous cycle, hormone levels and ovarian reserve function in rats, while increasing the proportion of collagen fibres in ovarian tissue. In terms of mechanism, cuproptosi...
Source: Environmental Pollution - May 7, 2024 Category: Environmental Health Authors: Ziyan Wang Wei Zhang Danyang Huang Huiwen Kang Jingyu Wang Ziyan Liu Guangyu Jiang Ai Gao Source Type: research
An Assessment of the Prevalence and Risk Factors of Hypertensive Crisis in Patients Who Visited the Emergency Outpatient Department (EOPD) at Adama Hospital Medical College, Adama, Oromia, Ethiopia: A 6-Month Prospective Study
Conclusions and Recommendations. Hypertensive crises are one of the most prevalent reasons for EOPD admission and are linked to significant consequences. At presentation, most of the study subjects were known hypertension patients. Diabetes mellitus was discovered to be a comorbid condition in one-quarter of them. Although more than half of the patients had improved, the death rate still remained high. Infrastructure and capacity building to provide hospitals with the requisite baseline investigations are among the government's recommendations. Health practitioners are expected to make improvements, such as by educating th...
Source: International Journal of Hypertension - May 7, 2024 Category: Cardiology Authors: Abel Tezera Abebe Yabets Tesfaye Kebede Bekri Delil Mohammed Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: Endocrine Reviews - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Identification and characterization of a TLR4 homologue in Eriocheir sinensis based on structure analysis
Dev Comp Immunol. 2024 May 5:105192. doi: 10.1016/j.dci.2024.105192. Online ahead of print.ABSTRACTToll-like receptor 4 (TLR4) plays an essential role in the activation of innate immunity by recognizing diverse pathogenic components of bacteria. Six Tolls were found in Eriocheir sinensis but have not yet been identified as mammalian TLR4 homolog. For this purpose, we predicted three-dimensional (3D) structures of EsTolls (EsToll1-6) with AlphaFold2. 3D structure of LRRs and TIR most had high accuracy (pLDDT > 70). By structure analysis, 3D structures of EsToll6 had a high overlap with HsTLR4. Moreover, we also predicted...
Source: Developmental and Comparative Immunology - May 7, 2024 Category: Allergy & Immunology Authors: Chenchen Shi Zhixin Jin Yanping Yu Zhuyun Tang Yuguo Zhang Chen Qu Ta-Hui Lin Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Cuproptosis is involved in decabromodiphenyl ether-induced ovarian dysfunction and the protective effect of melatonin
This study aimed to investigate the toxic effects of BDE-209 on the ovary and tried to improve ovarian function with melatonin. Herein, BDE-209 was administered orally to female SD rats for 60 days. Enzyme-linked immunosorbent assay, HE staining, transcriptome analysis, qPCR and immunohistochemical staining were used to explore and verify the potential mechanism. We found that BDE-209 exposure had effects on the ovary, as shown by abnormal changes in the estrous cycle, hormone levels and ovarian reserve function in rats, while increasing the proportion of collagen fibres in ovarian tissue. In terms of mechanism, cuproptosi...
Source: Environmental Pollution - May 7, 2024 Category: Environmental Health Authors: Ziyan Wang Wei Zhang Danyang Huang Huiwen Kang Jingyu Wang Ziyan Liu Guangyu Jiang Ai Gao Source Type: research
CAD1 contributes to osmotic tolerance in Arabidopsis thaliana by suppressing immune responses under osmotic stress
Biochem Biophys Res Commun. 2024 May 3;717:150049. doi: 10.1016/j.bbrc.2024.150049. Online ahead of print.ABSTRACTAcquired osmotolerance induced by initial exposure to mild salt stress is widespread across Arabidopsis thaliana ecotypes, but the mechanism underlying it remains poorly understood. To clarify it, we isolated acquired osmotolerance-deficient 1 (aod1), a mutant highly sensitive to osmotic stress, from ion-beam-irradiated seeds of Zu-0, an ecotype known for its remarkably high osmotolerance. Aod1 showed growth inhibition with spotted necrotic lesions on the rosette leaves under normal growth conditions on soil. H...
Source: Biochemical and Biophysical Research communications - May 7, 2024 Category: Biochemistry Authors: Yusuke Murakoshi Yasutaka Saso Minamo Matsumoto Kazuha Yamanaka Izumi Yotsui Yoichi Sakata Teruaki Taji Source Type: research
A two-step electrochemical method for separating Mg(OH) < sub > 2 < /sub > and CaCO < sub > 3 < /sub > : Application to RO reject and polluted groundwater
This study proposes a two-step electrochemical approach that separately recovers Ca2+ as CaCO3 and Mg2+ as Mg(OH)2. The first step uses an undivided cell with 3D electrodes and controlled flow directions to selectively precipitate CaCO3 on the electrode, keeping the cell removal efficiency. The second step employs a two-compartment cell with a cationic exchange membrane to recover Mg(OH)2. This approach was evaluated on RO reject water with high Ca2+ to Mg2+ ratio and industrial effluent-polluted groundwater with a low ratio. Treatment of domestic RO reject water using undivided cell specifically recovered 64% of CaCO3, al...
Source: Chemosphere - May 7, 2024 Category: Chemistry Authors: Manikandan Santhanam Rajeswari Selvaraj Maruthamuthu Sundaram Source Type: research
A two-step electrochemical method for separating Mg(OH) < sub > 2 < /sub > and CaCO < sub > 3 < /sub > : Application to RO reject and polluted groundwater
This study proposes a two-step electrochemical approach that separately recovers Ca2+ as CaCO3 and Mg2+ as Mg(OH)2. The first step uses an undivided cell with 3D electrodes and controlled flow directions to selectively precipitate CaCO3 on the electrode, keeping the cell removal efficiency. The second step employs a two-compartment cell with a cationic exchange membrane to recover Mg(OH)2. This approach was evaluated on RO reject water with high Ca2+ to Mg2+ ratio and industrial effluent-polluted groundwater with a low ratio. Treatment of domestic RO reject water using undivided cell specifically recovered 64% of CaCO3, al...
Source: Chemosphere - May 7, 2024 Category: Chemistry Authors: Manikandan Santhanam Rajeswari Selvaraj Maruthamuthu Sundaram Source Type: research
An Assessment of the Prevalence and Risk Factors of Hypertensive Crisis in Patients Who Visited the Emergency Outpatient Department (EOPD) at Adama Hospital Medical College, Adama, Oromia, Ethiopia: A 6-Month Prospective Study
Conclusions and Recommendations. Hypertensive crises are one of the most prevalent reasons for EOPD admission and are linked to significant consequences. At presentation, most of the study subjects were known hypertension patients. Diabetes mellitus was discovered to be a comorbid condition in one-quarter of them. Although more than half of the patients had improved, the death rate still remained high. Infrastructure and capacity building to provide hospitals with the requisite baseline investigations are among the government's recommendations. Health practitioners are expected to make improvements, such as by educating th...
Source: International Journal of Hypertension - May 7, 2024 Category: Cardiology Authors: Abel Tezera Abebe Yabets Tesfaye Kebede Bekri Delil Mohammed Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: Endocrine Reviews - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Identification and characterization of a TLR4 homologue in Eriocheir sinensis based on structure analysis
Dev Comp Immunol. 2024 May 5:105192. doi: 10.1016/j.dci.2024.105192. Online ahead of print.ABSTRACTToll-like receptor 4 (TLR4) plays an essential role in the activation of innate immunity by recognizing diverse pathogenic components of bacteria. Six Tolls were found in Eriocheir sinensis but have not yet been identified as mammalian TLR4 homolog. For this purpose, we predicted three-dimensional (3D) structures of EsTolls (EsToll1-6) with AlphaFold2. 3D structure of LRRs and TIR most had high accuracy (pLDDT > 70). By structure analysis, 3D structures of EsToll6 had a high overlap with HsTLR4. Moreover, we also predicted...
Source: Developmental and Comparative Immunology - May 7, 2024 Category: Allergy & Immunology Authors: Chenchen Shi Zhixin Jin Yanping Yu Zhuyun Tang Yuguo Zhang Chen Qu Ta-Hui Lin Source Type: research
