Extremophiles and their expanding biotechnological applications
Arch Microbiol. 2024 May 7;206(6):247. doi: 10.1007/s00203-024-03981-x.ABSTRACTMicrobial life is not restricted to any particular setting. Over the past several decades, it has been evident that microbial populations can exist in a wide range of environments, including those with extremes in temperature, pressure, salinity, and pH. Bacteria and Archaea are the two most reported types of microbes that can sustain in extreme environments, such as hot springs, ice caves, acid drainage, and salt marshes. Some can even grow in toxic waste, organic solvents, and heavy metals. These microbes are called extremophiles. There exist ...
Source: Archives of Microbiology - May 7, 2024 Category: Microbiology Authors: Manvi Rawat Mansi Chauhan Anita Pandey Source Type: research
Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF- κB-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells
Arch Microbiol. 2024 May 7;206(6):249. doi: 10.1007/s00203-024-03971-z.ABSTRACTEscherichia coli (E. coli) can induce severe clinical bovine mastitis, which is to blame for large losses experienced by dairy farms. Macrophage polarization into various states is in response to pathogen infections. Lycopene, a naturally occurring hydrocarbon carotenoid, relieved inflammation by controlling M1/M2 status of macrophages. Thus, we wanted to explore the effect of lycopene on polarization states of macrophages in E. coli-induced mastitis. Macrophages were cultivated with lycopene for 24, before E. coli inoculation for 6 h. Lycopene ...
Source: Archives of Microbiology - May 7, 2024 Category: Microbiology Authors: Cuicui Zhuang Ruoqing Zhang Jiangang Bai Xinying Zhang Jinhui Zhao Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Identification and characterization of a TLR4 homologue in Eriocheir sinensis based on structure analysis
Dev Comp Immunol. 2024 May 5:105192. doi: 10.1016/j.dci.2024.105192. Online ahead of print.ABSTRACTToll-like receptor 4 (TLR4) plays an essential role in the activation of innate immunity by recognizing diverse pathogenic components of bacteria. Six Tolls were found in Eriocheir sinensis but have not yet been identified as mammalian TLR4 homolog. For this purpose, we predicted three-dimensional (3D) structures of EsTolls (EsToll1-6) with AlphaFold2. 3D structure of LRRs and TIR most had high accuracy (pLDDT > 70). By structure analysis, 3D structures of EsToll6 had a high overlap with HsTLR4. Moreover, we also predicted...
Source: Developmental and Comparative Immunology - May 7, 2024 Category: Allergy & Immunology Authors: Chenchen Shi Zhixin Jin Yanping Yu Zhuyun Tang Yuguo Zhang Chen Qu Ta-Hui Lin Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: Endocrine Reviews - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
An Assessment of the Prevalence and Risk Factors of Hypertensive Crisis in Patients Who Visited the Emergency Outpatient Department (EOPD) at Adama Hospital Medical College, Adama, Oromia, Ethiopia: A 6-Month Prospective Study
Conclusions and Recommendations. Hypertensive crises are one of the most prevalent reasons for EOPD admission and are linked to significant consequences. At presentation, most of the study subjects were known hypertension patients. Diabetes mellitus was discovered to be a comorbid condition in one-quarter of them. Although more than half of the patients had improved, the death rate still remained high. Infrastructure and capacity building to provide hospitals with the requisite baseline investigations are among the government's recommendations. Health practitioners are expected to make improvements, such as by educating th...
Source: International Journal of Hypertension - May 7, 2024 Category: Cardiology Authors: Abel Tezera Abebe Yabets Tesfaye Kebede Bekri Delil Mohammed Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
An Assessment of the Prevalence and Risk Factors of Hypertensive Crisis in Patients Who Visited the Emergency Outpatient Department (EOPD) at Adama Hospital Medical College, Adama, Oromia, Ethiopia: A 6-Month Prospective Study
Conclusions and Recommendations. Hypertensive crises are one of the most prevalent reasons for EOPD admission and are linked to significant consequences. At presentation, most of the study subjects were known hypertension patients. Diabetes mellitus was discovered to be a comorbid condition in one-quarter of them. Although more than half of the patients had improved, the death rate still remained high. Infrastructure and capacity building to provide hospitals with the requisite baseline investigations are among the government's recommendations. Health practitioners are expected to make improvements, such as by educating th...
Source: International Journal of Hypertension - May 7, 2024 Category: Cardiology Authors: Abel Tezera Abebe Yabets Tesfaye Kebede Bekri Delil Mohammed Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: Endocrine Reviews - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: ENDOCR REV - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors
Endocr Rev. 2024 May 7:bnae015. doi: 10.1210/endrev/bnae015. Online ahead of print.ABSTRACTReceptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes, that synthesize cGMP in response to natriuretic peptides or other ligands. They are evolutionarily conserved from sea urchins to humans and regulate diverse physiologies. Most family members are phosphorylated on four to seven conserved serines or threonines at the beginning of their kinase homology domains. This review describes studies that demonstrate that phosphorylation and dephosphorylation are required for activation and inactivation of these e...
Source: Endocrine Reviews - May 7, 2024 Category: Endocrinology Authors: Lincoln R Potter Source Type: research
