Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats.
This study aimed to examine the effect of R. graveolens and rutin on memory in rats.Materials and methods: In this study animals were treated with the hydroalcholic extract of R. graveolens and rutin by IP injection for 10 days. Behavioural and biochemical tests as well as HPLC analysis and antioxidant activity of extract have been evaluated.Results: R. graveolens extract and rutin significantly increased learning and improved spatial memory, as well as secondary latency; moreover, there were significant increases in the serum and brain antioxidant capacity as well as the level of TBARS in serum and brain tissues. Result...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Colletotrichum gloesporioides inhibition using chitosan-Ruta graveolens L essential oil coatings: Studies in vitro and in situ on Carica papaya fruit.
In this study we assessed the efficacy of chitosan (CHI) (2%) emulsion added with Ruta graveolens L. essential oil (REO) at different concentrations (0.5%, 1.0% and 1.5%) to control C. gloesporioides grows both "in situ" and "in vitro" in papaya Maradol (Carica papaya L.). In vitro studies showed a decrease on fungal growth (mycelia diameter) with the increase of REO concentration, while 0.5% of REO induce a reduction of 56.42%, REO at 1.0% and 1.5% induced a reduction of 97%. Microscopic analysis showed irreversible deleterious morphological and ultrastructural alterations as well as changes in conidia morphology, and con...
Source: International Journal of Food Microbiology - May 2, 2020 Category: Food Science Authors: Peralta-Ruiz Y, Grande Tovar C, Sinning-Mangonez A, Bermont D, Pérez Cordero A, Paparella A, Chaves-López C Tags: Int J Food Microbiol Source Type: research
Separation and qualitative study of Ruta graveolens L. essential oil components by prep-GC, GC-QTOF-MS and NMR.
Abstract
In order to solve the problem of inaccuracy of using GC-QTOF-MS combined with NIST14 database in analyzing Ruta graveolens L. essential oil components, systematic isolation and characterization of chemicals from essential oil were carried on. Seventeen compounds which were 3 terpenoids, 8 lipid compounds, 3 alcohol compounds and 3 ketones were separated by preparative GC after dividing the essential oil into 5 groups of fractions by silica gel column. The chemical structures of isolated compounds were identified by GC-QTOF-MS and NMR. Three new in general compounds (50, 53 and 55) were isolated. A...
Source: Natural Product Research - April 26, 2020 Category: Biochemistry Authors: Li Y, Dong G, Bai X, Aimila A, Bai X, Maiwulanjiang M, Aisa HA Tags: Nat Prod Res Source Type: research
Molecules, Vol. 25, Pages 1688: Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films
rnandez
Chaur
The development of new biocompatible materials for application in the replacement of deteriorated tissues (due to accidents and diseases) has gained a lot of attention due to the high demand around the world. Tissue engineering offers multiple options from biocompatible materials with easy resorption. Chitosan (CS) is a biopolymer derived from chitin, the second most abundant polysaccharide in nature, which has been highly used for cell regeneration applications. In this work, CS films and Ruta graveolens essential oil (RGEO) were incorporated to obtain porous and resorbable materials, which did not ge...
Source: Molecules - April 6, 2020 Category: Chemistry Authors: Grande Tovar Castro Valencia Llano Navia Porras Delgado Ospina Valencia Zapata Herminsul Mina Hernandez Chaur Tags: Article Source Type: research
In Vitro Schistosomicidal Activity of the Alkaloid-Rich Fraction from Ruta graveolens L. (Rutaceae) and Its Characterization by UPLC-QTOF-MS.
In this study, we reported the in vitro schistosomicidal activity of the R. graveolens extract (Rg) and its active fraction (Rg-FAE). Also, the characterization of Rg-FAE by UPLC-ESI-QTOF-MS analysis and its in vitro antileishmanial activity against Leishmania braziliensis were also performed. In vitro schistosomicidal assays were assessed against adult worms of S. mansoni, while cell viability against peritoneal macrophages was measured by MTT assay. Rg (100 μg/mL) exhibited noticeable schistosomicidal activity, causing 100% mortality and decreasing motor activity of all adult male and female schistosomes, but with low...
Source: Evidence-based Complementary and Alternative Medicine - December 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Molecules, Vol. 24, Pages 4047: Essential Oil Composition of Ruta graveolens L. Fruits and Hyssopus officinalis Subsp. aristatus (Godr.) Nyman Biomass as a Function of Hydrodistillation Time
Dincheva
The aim of this study was to establish the kinetics regression models for yield and composition of Ruta graveolens fruit and Hyssopus officinalis subsp. aristatus aboveground biomass essential oil (EO), collected at different time intervals during the hydrodistillation process. The hypothesis was that collecting the EO fractions during specific time frames may result in EOs with dissimilar composition that may have differential use by the industry. Furthermore, we calculated the kinetics regression models for the composition of EO, isolated by hydrodistillation in a Clevenger-type apparatus and characterized ...
Source: Molecules - November 7, 2019 Category: Chemistry Authors: Ivanka B. Semerdjieva Marian Burducea Tess Astatkie Valtcho D. Zheljazkov Ivayla Dincheva Tags: Article Source Type: research
Synthesis of methylated anthranilate derivatives using engineered strains of Escherichia coli.
Abstract
Anthranilate derivates are used as flavoring and fragrant agents for a long period time. Recently, these compounds gain an attention due to the new biological functions including antinociceptive and analgesic activities. Three anthranilate derivatives, N-methylanthranilate, methyl anthrannilate, and methyl N-methylanthranilate were synthesized using metabolically engineered stains of Escherichia coli. NMT encoding N-methyltransferase from Ruta graveolens, AMAT encoding anthraniloyl-coenzyme A (CoA):methanol acyltransferase from Vitis labrusca, and PqsA encoding anthranilate Coenzyme A ligase from ...
Source: Journal of Microbiology and Biotechnology - June 3, 2019 Category: Biotechnology Authors: Lee HL, Kim SY, Kim EJ, Han DY, Kim BG, Ahn JH Tags: J Microbiol Biotechnol Source Type: research
In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids.
Abstract
The aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L.) were produced and characterized for their morphology, mean particle size, zeta potential, and encapsulation efficiency. A final topical formulation was obtained by dispersing chitosan/TPP...
Source: AAPS PharmSciTech - December 17, 2018 Category: Drugs & Pharmacology Authors: Cefali LC, Ataide JA, Eberlin S, da Silva Gonçalves FC, Fernandes AR, Marto J, Ribeiro HM, Foglio MA, Mazzola PG, Souto EB Tags: AAPS PharmSciTech Source Type: research
Molecules, Vol. 23, Pages 2693: Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors
oura Veiga
Eight alkaloids (1–8) were isolated from Ruta graveolens, and their herbicide activities were evaluated through in vitro, semivivo, and in vivo assays. The most relevant results were observed for Compounds 5 and 6–8 at 150 μM, which decreased dry biomass by 20% and 23%, respectively. These are significant results since they presented similar values with the positive control, commercial herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Based on the performed assays, Compound 5 (graveoline) is classified as an electron-transport inhibitor during the light phase of...
Source: Molecules - October 19, 2018 Category: Chemistry Authors: Ol ívia Moreira Sampaio Lucas Campos Curcino Vieira Barbara Sayuri Bellete Beatriz King-Diaz Blas Lotina-Hennsen Maria F átima das Graças Fernandes da Silva Thiago Andr é Moura Veiga Tags: Article Source Type: research
Therapeutic Management of Peritoneal Ascitic Sarcomatosis By Ruta graveolens: A Study In Experimental Mice
ConclusionOur observations revealed that loco-regional Ruta administration resulted in the anti-neoplastic effect on peritoneal sarcoma related ascites and the alteration of vital regulatory molecules which depicted the therapeutic utility of Ruta in the management of peritoneal malignant ascites.Graphical AbstractThe graphical Abstract depicts the experimental findings in brief: An average increase in life-span of the Ruta treated mice in comparison to the control group due to enhanced innate immunity and rate of tumour cell apoptosis coupled with decreased rate of tumour cell proliferation and neoplastic activity. (Sourc...
Source: Pathology Research and Practice - July 11, 2018 Category: Pathology Source Type: research
Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice.
CONCLUSION: Our observations revealed that loco-regional Ruta administration resulted in the anti-neoplastic effect on peritoneal sarcoma related ascites and the alteration of vital regulatory molecules which depicted the therapeutic utility of Ruta in the management of peritoneal malignant ascites.
PMID: 30025594 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 11, 2018 Category: Pathology Authors: Law S, Sanyal S, Chatterjee R, Law A, Law A, Chattopadhyay S Tags: Pathol Res Pract Source Type: research
Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via mek-erk1/2 pathway.
In conclusion, we report that RGWE is able to significantly impair vessels network formation without affecting cell viability, preventing ERK1/2 activation and, in turn, down-regulating VEGF and nestin expression. These findings point to RGWE as a potential therapeutic tool capable to interfere with pathologic angiogenesis.
PMID: 29366810 [PubMed - as supplied by publisher] (Source: Experimental Cell Research)
Source: Experimental Cell Research - January 20, 2018 Category: Cytology Authors: Gentile M, Russo R, Pastorino O, Cioffi S, Barbieri F, Illingworth EA, Grieco M, Chambery A, Colucci-D'Amato L Tags: Exp Cell Res Source Type: research
"Not tonight zebrafish": the effects of Ruta graveolens on reproduction.
CONCLUSION: RE has endocrine disrupting potential in fish, which has important implications for studying the effects of unintentional pharmaceutical exposure. Moreover, the results demonstrate that drug exposure may affect more than just the overall level of behaviour, emphasizing the relevance of examining the effects of individual exposure. We reinforce the use of zebrafish as a model organism in physiology and behaviour, and raise concerns about the toxic effects of RE in non-target organisms such as aquatic vertebrates, which may ultimately affect human health.
PMID: 29295655 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 5, 2018 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Auxin-cytokinin synergism in vitro for producing genetically stable plants of Ruta graveolens using shoot tip meristems
Publication date: Available online 27 September 2017 Source:Saudi Journal of Biological Sciences Author(s): Mohammad Faisal, Naseem Ahmad, Mohammad Anis, Abdulrahman A. Alatar, Ahmad A. Qahtan An efficient micropropagation protocol was developed for Ruta graveolens Linn. using shoot tip meristems derived from a 4-month-old field grown plant. In vitro shoot regeneration and proliferation was accomplished on Murashige and Skoogs (MS) semi-solid medium in addition to different doses of cytokinins viz.6- benzyl adenine (BA), Kinetin (Kin) or 2-isopetynyl adenine (2iP), singly or in combination with auxins viz. indole-3-...
Source: Saudi Journal of Biological Sciences - September 28, 2017 Category: Biology Source Type: research
Efficacy and Tolerability of Phytomedicines in Multiple Sclerosis Patients: A Review
AbstractMultiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that can cause cognition, mobility, and sensory impairments. It is considered one of the most common non-traumatic causes of disability in the world. The aim of the present article was to review the clinical evidence related to medicinal plants in the management of MS symptoms. Electronic databases, including the Cochrane Library, Pubmed, and Scopus, were searched for entries from 1966 to February 2017. Only clinical studies were included in this review. Different medicinal plants have positive effects o...
Source: CNS Drugs - September 25, 2017 Category: Neurology Source Type: research
