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Drug: Dexamethasone
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Total 6433 results found since Jan 2013.
Oral cortisol and dexamethasone intake: differential physiology and transcriptional responses in the marine juvenile Sparus aurata
This study approached the long-term oral administration of cortisol (F) and dexamethasone (DEX), two synthetic glucocorticoids, compared to a control group (CT) in the juveniles of a marine teleost, the gilthead seabream (Sparus aurata). Physiologically, DEX treatment impaired growth, which appears to be linked to carbohydrate allocation in muscle and liver, hepatic triglycerides depletion, and reduced hematocrit. Hypophyseal gh mRNA expression was 2-fold higher in DEX than in CT or F groups. Similarly, hypothalamic trh and hypophyseal pomcb followed this pattern. Plasma cortisol levels were significantly lower in DEX than...
Source: General and Comparative Endocrinology - August 28, 2023 Category: Endocrinology Authors: A Barany J Fuentes V Valderrama A Broz-Ruiz G Mart ínez-Rodríguez J M Mancera Source Type: research
Exercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Production
CONCLUSION: Our results indicate that long-term administration of dexamethasone is associated with an increase in cardiac 4-HNE levels, which is hindered by the addition of exercise training.PMID:37624527 | DOI:10.1007/s10557-023-07506-4
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Umit Hayta Senay Akin Irem Gungor Inci Tugce Colluoglu Umit Guray Yesim Akin Haydar A Demirel Source Type: research
Prevalence and clinical features of armadillo repeat-containing 5 mutations carriers in a single center cohort of patients with bilateral adrenal incidentalomas
CONCLUSIONS: In MACS+ BAI patients, germline ARMC5 gene pathogenic variants are frequent. Further studies are needed to elucidate the pathophysiological role of somatic ARMC5 pathogenic variants on adrenal tumor development in otherwise wild-type (WT) patients.PMID:37625448 | DOI:10.1093/ejendo/lvad088
Source: European Journal of Endocrinology - August 25, 2023 Category: Endocrinology Authors: Morelli Valentina Elli Francesca Marta Frigerio Sofia Vena Walter Palmieri Serena Lucca Camilla Maffini Maria Antonia Contarino Andrea Bagnaresi Francesca Mantovani Giovanna Arosio Maura Source Type: research
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Eur J Pharmacol. 2023 Aug 22:175991. doi: 10.1016/j.ejphar.2023.175991. Online ahead of print.ABSTRACTThe use of repurposing drugs that may have neoplastic and anticancer effects increases the efficiency and decrease resistance to chemotherapy drugs through a biochemical and mechanical transduction mechanisms through modulation of fibroblast/fibrosis remodeling in tumor microenvironment (TME). Interestingly, fibroblast/fibrosis remodeling plays a vital role in mediating cancer metastasis and drug resistance after immune chemotherapy. The most essential hypothesis for induction of chemo-immunotherapy resistance is via activ...
Source: European Journal of Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Mahboubeh Tajaldini Amirhoushang Poorkhani Taghi Amiriani Amirhossein Amiriani Hossein Javid Parham Aref Farahnazsadat Ahmadi Somayeh Sadani Vahid Khori Source Type: research
Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection
In this study, we describe a lethal model of CCHFV infection using a mouse-adapted strain of CCHFV (MA-CCHFV) in adult wild-type male mice. Infected mice developed high viral loads, tissue pathology, inflammatory immune responses before ultimately succumbing to the infection. We used the model to evaluate the protective efficacy of nucleoside analogs monulpiravir, favipiravir, ribavirin, the antibiotic tigecycline and the corticosteroids dexamethasone and methylprednisolone against lethal CCHFV infection. Tigecycline, monulpiravir and the corticosteroids failed to protect mice from lethal MA-CCHFV infection. In contrast, f...
Source: Antiviral Research - August 23, 2023 Category: Virology Authors: Thomas Tipih Kimberly Meade-White Deepashri Rao Trenton Bushmaker Mathew Lewis Carl Shaia Heinz Feldmann David W Hawman Source Type: research
Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma
Haematologica. 2023 Aug 24. doi: 10.3324/haematol.2022.282624. Online ahead of print.ABSTRACTTo improve patient outcomes in the otherwise incurable hematologic malignancy of multiple myeloma (MM), a key paradigm includes initial treatment to establish disease control rapidly followed by maintenance therapy to ensure durability of response with manageable toxicity. However, patient prognosis becomes worse after relapse, and the disease burden and drug toxicities are generally more challenging with subsequent lines of therapy. It is therefore particularly important that patients with newly diagnosed multiple myeloma (NDMM) r...
Source: Haematologica - August 23, 2023 Category: Hematology Authors: Paul G Richardson Brian G Durie Laura Rosi ñol Maria-Victoria Mateos Angela Dispenzieri Philippe Moreau Shaji Kumar Noopur Raje Nikhil Munshi Jacob P Laubach Peter O'Gorman Elizabeth O'Donnell Peter Voorhees Thierry Facon Joan Blad é Sagar Lonial Aurore Source Type: research
Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
CONCLUSIONS: Administration of JP combined with MPA restores tumor-induced cachexia conditions. In addition, the profound effect of JP combined with MPA on tumor-induced cachexia may be due to its inhibition of muscle proteolysis (E3 ubiquitinase system).PMID:37612478 | DOI:10.1007/s11655-023-3702-4
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Qi Li Zhao-di Kong Huan Wang Hong-Hui Gu Zhong Chen Shi-Guang Li Yi-Qi Chen Yu Cai Zhen-Jiang Yang Source Type: research
Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma
Haematologica. 2023 Aug 24. doi: 10.3324/haematol.2022.282624. Online ahead of print.ABSTRACTTo improve patient outcomes in the otherwise incurable hematologic malignancy of multiple myeloma (MM), a key paradigm includes initial treatment to establish disease control rapidly followed by maintenance therapy to ensure durability of response with manageable toxicity. However, patient prognosis becomes worse after relapse, and the disease burden and drug toxicities are generally more challenging with subsequent lines of therapy. It is therefore particularly important that patients with newly diagnosed multiple myeloma (NDMM) r...
Source: Haematologica - August 23, 2023 Category: Hematology Authors: Paul G Richardson Brian G Durie Laura Rosi ñol Maria-Victoria Mateos Angela Dispenzieri Philippe Moreau Shaji Kumar Noopur Raje Nikhil Munshi Jacob P Laubach Peter O'Gorman Elizabeth O'Donnell Peter Voorhees Thierry Facon Joan Blad é Sagar Lonial Aurore Source Type: research
Quantification of transcriptome changes to investigate the role of glucocorticoid receptor-RNA binding during dexamethasone treatment
The objective of our study was to further characterize the relationship between GR function and RNA binding by measuring changes in the glucocorticoid-driven transcriptome in the presence of a GR mutant that exhibited reduced RNA affinity.DATA DESCRIPTION: GR was activated in three cell lines containing GR constructs (GR-HaloTag). One of the cell lines contained a wild-type GR-HaloTag. Another contained GR-HaloTag with a mutation that reduced RNA affinity and slightly reduced DNA affinity. The third cell line contained GR-HaloTag with a mutation that only slightly reduced DNA affinity. All three cell lines were treated wit...
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Nickolaus C Lammer Mary A Allen Robert T Batey Deborah S Wuttke Source Type: research
