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Drug: Dexamethasone
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Total 6433 results found since Jan 2013.
Venous Thromboembolism Risk in Patients With Newly Diagnosed Multiple Myeloma Treated with Carfilzomib or Bortezomib in Combination With Lenalidomide and Dexamethasone
CONCLUSION: In this cohort, KRd was not associated with an increase in VTE risk compared to VRd, contrary to prior literature.PMID:37543510 | DOI:10.1016/j.clml.2023.07.009
Source: Clinical Lymphoma and Myeloma - August 5, 2023 Category: Cancer & Oncology Authors: Alexa J Loncharich Mark A Fiala Michael J Slade Angela Vickroy Margaret Kavanaugh Carmen Wilson Mark A Schroeder Keith Stockerl-Goldstein Ravi Vij Kristen M Sanfilippo Source Type: research
Efficacy and safety of bortezomib plus dexamethasone in patients with refractory primary immune thrombocytopenia: A single-center study
Asian J Surg. 2023 Aug 2:S1015-9584(23)01129-6. doi: 10.1016/j.asjsur.2023.07.123. Online ahead of print.NO ABSTRACTPMID:37541902 | DOI:10.1016/j.asjsur.2023.07.123
Source: Asian Journal of Surgery - August 4, 2023 Category: Surgery Authors: Li-Na Liu Yu-Shan Cui Bai-Jun Fang Source Type: research
CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation
Neuropharmacology. 2023 Aug 2;239:109674. doi: 10.1016/j.neuropharm.2023.109674. Online ahead of print.ABSTRACTThe molecular processes that underlie long-term memory formation involve signaling pathway activation by neurotransmitter release, which induces the expression of immediate early genes, such as Zif268, having a key role in memory formation. In this work, we show that the cannabinoid CB1 receptor signaling is necessary for the effects of dexamethasone on the behavioral response in an inhibitory avoidance task, on dexamethasone-induced ERK phosphorylation, and on dexamethasone-dependent Zif268 expression. Furthermor...
Source: Neuropharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Gina Granja-Galeano Ana Paula Dominguez-Rubio C Daniel Zappia Manuel Wolfson Sara Sanz-Blasco Julieta Aisemberg Maria Zorrilla-Zubilete Natalia Fernandez Ana Franchi Carlos P Fitzsimons Federico Monczor Source Type: research
Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway
CONCLUSIONS: ADSCs restore the pathogenesis of Dex-induced muscle atrophy with an increased number of type I fibres, stronger muscle strength, faster recovery rate and more anti-fatigue ability via ERK1/2 signalling pathway. The inhibition of muscle atrophy-associated genes by ADSCs offered this treatment as an intervention option for muscle-associated diseases. Taken together, our findings suggested that adipose-derived mesenchymal stem cell therapy could be a new treatment option for patient with Dex-induced muscle atrophy.PMID:37542297 | DOI:10.1186/s13287-023-03418-0
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Belle Yu-Hsuan Wang Allen Wei-Ting Hsiao Hoi Ting Shiu Nicodemus Wong Amanda Yu-Fan Wang Chien-Wei Lee Oscar Kuang-Sheng Lee Wayne Yuk-Wai Lee Source Type: research
Efficacy and safety of bortezomib plus dexamethasone in patients with refractory primary immune thrombocytopenia: A single-center study
Asian J Surg. 2023 Aug 2:S1015-9584(23)01129-6. doi: 10.1016/j.asjsur.2023.07.123. Online ahead of print.NO ABSTRACTPMID:37541902 | DOI:10.1016/j.asjsur.2023.07.123
Source: Asian Journal of Surgery - August 4, 2023 Category: Surgery Authors: Li-Na Liu Yu-Shan Cui Bai-Jun Fang Source Type: research
Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway
CONCLUSIONS: ADSCs restore the pathogenesis of Dex-induced muscle atrophy with an increased number of type I fibres, stronger muscle strength, faster recovery rate and more anti-fatigue ability via ERK1/2 signalling pathway. The inhibition of muscle atrophy-associated genes by ADSCs offered this treatment as an intervention option for muscle-associated diseases. Taken together, our findings suggested that adipose-derived mesenchymal stem cell therapy could be a new treatment option for patient with Dex-induced muscle atrophy.PMID:37542297 | PMC:PMC10403871 | DOI:10.1186/s13287-023-03418-0
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Belle Yu-Hsuan Wang Allen Wei-Ting Hsiao Hoi Ting Shiu Nicodemus Wong Amanda Yu-Fan Wang Chien-Wei Lee Oscar Kuang-Sheng Lee Wayne Yuk-Wai Lee Source Type: research
CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation
Neuropharmacology. 2023 Aug 2:109674. doi: 10.1016/j.neuropharm.2023.109674. Online ahead of print.ABSTRACTThe molecular processes that underlie long-term memory formation involve signaling pathway activation by neurotransmitter release, which induces the expression of immediate early genes, such as Zif268, having a key role in memory formation. In this work, we show that the cannabinoid CB1 receptor signaling is necessary for the effects of dexamethasone on the behavioral response in an inhibitory avoidance task, on dexamethasone-induced ERK phosphorylation, and on dexamethasone-dependent Zif268 expression. Furthermore, w...
Source: Neuropharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Gina Granja-Galeano Ana Paula Dominguez Rubio C Daniel Zappia Manuel Wolfson Sara Sanz Blasco Julieta Aisemberg Maria Zorrilla Zubilete Natalia Fernandez Ana Franchi Carlos P Fitzsimons Federico Monczor Source Type: research
Ionically bridged dexamethasone sodium phosphate-zinc-PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis
Arch Pharm Res. 2023 Aug 3. doi: 10.1007/s12272-023-01456-z. Online ahead of print.ABSTRACTColon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lact...
Source: Archives of Pharmacal Research - August 3, 2023 Category: Drugs & Pharmacology Authors: Aruzhan Saparbayeva Juho Lee Shwe Phyu Hlaing Jihyun Kim Dongmin Kwak Hyunwoo Kim Eun Hee Lee Seonghwan Hwang Min-Soo Kim Hyung Ryong Moon Yunjin Jung Jin-Wook Yoo Source Type: research
Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation
Toxicol Appl Pharmacol. 2023 Aug 1:116649. doi: 10.1016/j.taap.2023.116649. Online ahead of print.ABSTRACTSteroid-induced avascular necrosis of femoral head (SANFH) is a common disorder worldwide with high disability. Overdose of glucocorticoid (GC) is the most common non-traumatic cause of SANFH. Up until now, there are limited therapeutic strategies for curing SANFH, and the mechanisms underlying SANFH progression remain unclear. Nevertheless, Osteogenic dysfunction is considered to be one of the crucial pathobiological mechanisms in the development of SANFH, which involves mouse bone marrow mesenchymal stem cells (BMSCs...
Source: Toxicology and Applied Pharmacology - August 3, 2023 Category: Toxicology Authors: Qian Liu Yuyang Wu Sisi Li Somy Yoon Jiaxin Zhang Xiaoyi Wang Luoshuang Hu Chenying Su Chunwu Zhang Yungang Wu Source Type: research
Ionically bridged dexamethasone sodium phosphate-zinc-PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis
Arch Pharm Res. 2023 Aug 3. doi: 10.1007/s12272-023-01456-z. Online ahead of print.ABSTRACTColon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lact...
Source: Archives of Pharmacal Research - August 3, 2023 Category: Drugs & Pharmacology Authors: Aruzhan Saparbayeva Juho Lee Shwe Phyu Hlaing Jihyun Kim Dongmin Kwak Hyunwoo Kim Eun Hee Lee Seonghwan Hwang Min-Soo Kim Hyung Ryong Moon Yunjin Jung Jin-Wook Yoo Source Type: research
Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production
Chem Biodivers. 2023 Aug 2:e202301037. doi: 10.1002/cbdv.202301037. Online ahead of print.ABSTRACTFour undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5-17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)-gaylussacin (1), 6''-O-galloylgaylussacin sodium salt (2), 6''-O-galloylgaylussacin (3), 4'-O-[β-D-glucopyranosyl-(1→6)-glucopyranosyl]oxy-2'-hydroxy-6'-methoxydihydrochalcone (4), gaylussacin (5), pinosi...
Source: Chemistry and Biodiversity - August 2, 2023 Category: Biochemistry Authors: Phan Van Kiem Bui Hai Ninh Bui Huu Tai Nguyen Xuan Nhiem Pham Hai Yen Nguyen Huy Hoang Do Thi Trang Duong Thi Dung Nguyen Van Tuyen Le Tuan Anh Source Type: research
Ovine CRH stimulation and 8 mg dexamethasone suppression tests in 323 patients with ACTH-dependent Cushing's syndrome
CONCLUSIONS: CRH is a valuable tool to correctly diagnose the etiology of ACTH-dependent CS. Its current world-wide unavailability impedes optimal management of these patients.PMID:37531629 | DOI:10.1210/clinem/dgad454
Source: The Journal of Clinical Endocrinology and Metabolism - August 2, 2023 Category: Endocrinology Authors: Henrik Elenius Raven McGlotten Lynnette K Nieman Source Type: research
Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production
Chem Biodivers. 2023 Aug 2:e202301037. doi: 10.1002/cbdv.202301037. Online ahead of print.ABSTRACTFour undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5-17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)-gaylussacin (1), 6''-O-galloylgaylussacin sodium salt (2), 6''-O-galloylgaylussacin (3), 4'-O-[β-D-glucopyranosyl-(1→6)-glucopyranosyl]oxy-2'-hydroxy-6'-methoxydihydrochalcone (4), gaylussacin (5), pinosi...
Source: Chemistry and Biodiversity - August 2, 2023 Category: Biochemistry Authors: Phan Van Kiem Bui Hai Ninh Bui Huu Tai Nguyen Xuan Nhiem Pham Hai Yen Nguyen Huy Hoang Do Thi Trang Duong Thi Dung Nguyen Van Tuyen Le Tuan Anh Source Type: research
Ovine CRH stimulation and 8 mg dexamethasone suppression tests in 323 patients with ACTH-dependent Cushing's syndrome
CONCLUSIONS: CRH is a valuable tool to correctly diagnose the etiology of ACTH-dependent CS. Its current world-wide unavailability impedes optimal management of these patients.PMID:37531629 | DOI:10.1210/clinem/dgad454
Source: The Journal of Clinical Endocrinology and Metabolism - August 2, 2023 Category: Endocrinology Authors: Henrik Elenius Raven McGlotten Lynnette K Nieman Source Type: research
