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Cancer: Lung Cancer
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Total 37399 results found since Jan 2013.
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Technology in Cancer Research and Treatment - September 20, 2023 Category: Cancer & Oncology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells
Mol Biol Cell. 2023 Sep 20:mbcE23050152. doi: 10.1091/mbc.E23-05-0152. Online ahead of print.ABSTRACTAlthough the RAS oncogene has been extensively studied, new aspects concerning its role and regulation in normal biology and cancer continue to be discovered. Recently, others and we have shown that the mechanistic Target of Rapamycin Complex 2 (mTORC2) is a Ras effector in Dictyostelium and mammalian cells. mTORC2 plays evolutionarily conserved roles in cell survival and migration and has been linked to tumorigenesis. Since RAS is often mutated in lung cancer, we investigated whether a Ras-mTORC2 pathway contributes to enh...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Alyssa N Werner Avani I Kumar Pascale G Charest Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells
Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants ...
Source: BMC Complementary and Alternative Medicine - September 20, 2023 Category: Complementary Medicine Authors: Edmilson Willian Propheta dos Santos, Rauan Cruz de Sousa, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Flaviano Melo Ottoni, Raquel Geralda Isid ório, Waldecy de Lucca Junior, Ricardo José Alves, Ricardo Scher and Cristiane Bani Corrêa Tags: Research Source Type: research
Clinical utility of inflammatory and nutritious index as therapeutic prediction of nivolumab plus ipilimumab in advanced NSCLC
CONCLUSION: The NLR, PLR, SII, PNI, ALI, and GPS were significantly associated with the outcome of Nivo-Ipi treatment in patients with NSCLC. The PNI was the most suitable marker regardless of histological type. The SII and PNI were the most promising markers for patients with and without PD-L1 expression, respectively.PMID:37725914 | DOI:10.1159/000534169
Source: Oncology - September 19, 2023 Category: Cancer & Oncology Authors: Ou Yamaguchi Kyoichi Kaira Hisao Imai Atsuto Mouri Ayako Shiono Yu Miura Kosuke Hashimoto Kunihiko Kobayashi Hiroshi Kagamu Source Type: research
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research
Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection
CONCLUSIONS: These observations indicate that the distinct biological processes of uscfDNA and that FE peaks, fragmentomics, end-motifs, and G-Quad signatures are uscfDNA features with promising biomarker potential. These findings further justify its exploration as a distinct class of biomarker to augment pre-existing liquid biopsy approaches.PMID:37725931 | DOI:10.1093/clinchem/hvad131
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Jordan Cheng Neeti Swarup Feng Li Misagh Kordi Chien-Chung Lin Szu-Chun Yang Wei-Lun Huang Mohammad Aziz Yong Kim David Chia Yu-Min Yeh Fang Wei David Zheng Liying Zhang Matteo Pellegrini Wu-Chou Su David T W Wong Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
CIN2, Abdominal Pain, Lung Cancer Screening, Postpartum Hemorrhage, Faltering Growth
Am Fam Physician. 2023 Sep;108(3):235.NO ABSTRACTPMID:37725451
Source: Pain Physician - September 19, 2023 Category: Anesthesiology Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis
CONCLUSION: SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis. These findings not only advance our understanding of the molecular mechanisms driving TKI resistance, but also offer novel alternative strategies for the treatment of lung cancer.PMID:37725242 | DOI:10.1007/s00432-023-05416-4
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Fang Huang Jian Cui Jingxuan Wan Xue Yuan Yuanzhe Zhu Xiangxiang Wu Wei Zuo Tiantian Zhao Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Cancer Research - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/ β-catenin pathway
In this study, immunohistochemistry was used to analyze the expression of aldolase, fructose-bisphosphate C (ALDOC) protein in tumor tissues and adjacent non-malignant tissues from 79 NSCLC patients. Our findings revealed that ALDOC was overexpressed in NSCLC tissues. ALDOC expression was associated with lymph node metastasis, lymphatic metastasis and pathological stage. In addition, Kaplan-Meier analysis showed that higher ALDOC levels were indicative of a poorer prognosis. Additionally, we observed elevated ALDOC mRNA levels in NSCLC cell lines relative to normal cells. To investigate the functional roles of ALDOC, we in...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Bin Shang Fengjuan Lu Shujuan Jiang Mengmeng Xing Xinyu Mao Guanghai Yang Hao Zhang Source Type: research
Impact of liver metastases status on survival outcomes of first-line immunotherapy in extensive stage small cell lung cancer: a systematic review and meta-analysis
CONCLUSIONS: First-line immunotherapy plus chemotherapy significantly improved PFS and OS in ES-SCLC patients without liver metastases compared to chemotherapy alone. However, patients with liver metastases did not experience comparable benefits.PMID:37724893 | DOI:10.18632/aging.205035
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Yan Lin Wei Jiang Cui-Yun Su Xin-Bin Pan Source Type: research
