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Cancer: Lung Cancer
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Total 37399 results found since Jan 2013.
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Genitourinary Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research
Distinct Features of Plasma Ultrashort Single-Stranded Cell-Free DNA as Biomarkers for Lung Cancer Detection
CONCLUSIONS: These observations indicate that the distinct biological processes of uscfDNA and that FE peaks, fragmentomics, end-motifs, and G-Quad signatures are uscfDNA features with promising biomarker potential. These findings further justify its exploration as a distinct class of biomarker to augment pre-existing liquid biopsy approaches.PMID:37725931 | DOI:10.1093/clinchem/hvad131
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Jordan Cheng Neeti Swarup Feng Li Misagh Kordi Chien-Chung Lin Szu-Chun Yang Wei-Lun Huang Mohammad Aziz Yong Kim David Chia Yu-Min Yeh Fang Wei David Zheng Liying Zhang Matteo Pellegrini Wu-Chou Su David T W Wong Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
Lobar or sublobar resection for early-stage second primary lung cancer ≤ 3 cm in size: a SEER population-based study
CONCLUSION: The OS of sublobar resection was not significantly different from that of lobar resection for early-stage SPLC. For SPLC with a 2-3 cm tumor size, lobar resection is more advantageous than sublobar resection.PMID:37725243 | DOI:10.1007/s00432-023-05396-5
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Ke Zhao Chunqiu Xia Minghan Qiu Zhen Yang Tingkai Cui Teng Song Shuping Li Hanwei Mei Yang Zheng Huaqing Wang Source Type: research
SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis
CONCLUSION: SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis. These findings not only advance our understanding of the molecular mechanisms driving TKI resistance, but also offer novel alternative strategies for the treatment of lung cancer.PMID:37725242 | DOI:10.1007/s00432-023-05416-4
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Fang Huang Jian Cui Jingxuan Wan Xue Yuan Yuanzhe Zhu Xiangxiang Wu Wei Zuo Tiantian Zhao Source Type: research
Development and validation of the CAIL prognostic score in non-small cell lung cancer patients with malignant pleural effusion
CONCLUSIONS: For NSCLC patients with MPE, the validated CAIL prognostic score integrates clinical characteristics and therapeutic modalities to predict survival.PMID:37723659 | DOI:10.1111/crj.13700
Source: Clinical Lung Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Tianyuan Li Panwen Tian Qin Huang Hao Zeng Qi Wei Yalun Li Source Type: research
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Colorectal Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research
Nomogram based on clinical characteristics and radiological features for the preoperative prediction of spread through air spaces in patients with clinical stage IA non-small cell lung cancer: a multicenter study
CONCLUSION: The nomogram created in this study, based on clinical characteristics and radiological features, has a high diagnostic efficiency for predicting the STAS status in patients with clinical stage IA NSCLC and may support the creation of personalized treatment strategies before surgery.PMID:37724737 | DOI:10.4274/dir.2023.232404
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 19, 2023 Category: Radiology Authors: Yun Wang Deng Lyu Di Zhang Lei Hu Junhong Wu Wenting Tu Yi Xiao Li Fan Shiyuan Liu Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
CIN2, Abdominal Pain, Lung Cancer Screening, Postpartum Hemorrhage, Faltering Growth
Am Fam Physician. 2023 Sep;108(3):235.NO ABSTRACTPMID:37725451
Source: American Family Physician - September 19, 2023 Category: Primary Care Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Clinical Cancer Research - September 19, 2023 Category: Cancer & Oncology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
Clinical utility of inflammatory and nutritious index as therapeutic prediction of nivolumab plus ipilimumab in advanced NSCLC
CONCLUSION: The NLR, PLR, SII, PNI, ALI, and GPS were significantly associated with the outcome of Nivo-Ipi treatment in patients with NSCLC. The PNI was the most suitable marker regardless of histological type. The SII and PNI were the most promising markers for patients with and without PD-L1 expression, respectively.PMID:37725914 | DOI:10.1159/000534169
Source: Oncology - September 19, 2023 Category: Cancer & Oncology Authors: Ou Yamaguchi Kyoichi Kaira Hisao Imai Atsuto Mouri Ayako Shiono Yu Miura Kosuke Hashimoto Kunihiko Kobayashi Hiroshi Kagamu Source Type: research
Nomogram based on clinical characteristics and radiological features for the preoperative prediction of spread through air spaces in patients with clinical stage IA non-small cell lung cancer: a multicenter study
CONCLUSION: The nomogram created in this study, based on clinical characteristics and radiological features, has a high diagnostic efficiency for predicting the STAS status in patients with clinical stage IA NSCLC and may support the creation of personalized treatment strategies before surgery.PMID:37724737 | DOI:10.4274/dir.2023.232404
Source: Diagnostic and Interventional Radiology - September 19, 2023 Category: Radiology Authors: Yun Wang Deng Lyu Di Zhang Lei Hu Junhong Wu Wenting Tu Yi Xiao Li Fan Shiyuan Liu Source Type: research
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
CONCLUSIONS AND CLINICAL RELEVANCE: We characterized an extensive proteomic landscape of BrMs and gliomas. These findings have promising implications for the development of targeted therapies for BrMs and gliomas.PMID:37726528 | DOI:10.1002/prca.202300010
Source: Clinical Breast Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Shuang Yang Chengbin Zhou Lei Zhang Yueting Xiong Yongtao Zheng Liuguan Bian Xiaohui Liu Source Type: research
