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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Single Fraction vs. Fractionated Preoperative Radiosurgery for Resected Brain Metastases: a PROPS-BM International Multicenter Cohort Study
CONCLUSIONS: Preoperative MF-SRS was associated with significantly reduced risk of cavity LR in both the unmatched and PSM analyses. There was no difference in ARE, MD, or OS based on fractionation. MF-SRS may be a preferred option for neoadjuvant RT of resected brain metastases. Additional confirmatory studies are needed. A phase III randomized trial of single fraction preoperative vs. postoperative SRS (NRG-BN012) is ongoing (NCT05438212).PMID:37717787 | DOI:10.1016/j.ijrobp.2023.09.012
Source: Health Physics - September 17, 2023 Category: Physics Authors: Roshan S Prabhu Tobi Akinyelu Zachary K Vaslow Jennifer K Matsui Neda Haghighi Tu Dan Mark V Mishra Erin S Murphy Susan Boyles Haley K Perlow Joshua D Palmer Cristian Udovicich Toral R Patel Zabi Wardak Graeme F Woodworth Alexander Ksendzovsky Kailin Yang Source Type: research
The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy
CONCLUSION: The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.PMID:37716368 | DOI:10.1002/acm2.14162
Source: Journal of Applied Clinical Medical Physics - September 16, 2023 Category: Physics Authors: Atefeh Rostami Mostafa Robatjazi Seyed Alireza Javadinia Nematullah Shomoossi Ramin Shahraini Source Type: research
Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer
Acta Biochim Pol. 2023 Sep 16. doi: 10.18388/abp.2020_6501. Online ahead of print.ABSTRACTBrain metastases (BM) are associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). Considering that, LGAS8-AS1-mediated progression of BM was probed in NSCLC. The clinical characteristics of 60 NSCLC patients (30 without BM and 30 with BM) were analyzed. NSCLC patients with BM had higher levels of LGALS8-AS1 than NSCLC patients without BM. Depleting LGALS8-AS1 prevented NSCLC cell proliferation, migration, invasion, and angiogenesis in vitro, and NSCLC tumorigenesis and BM in vivo. LGALS8-AS1 targeted miR-88...
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Jian Zhong Bo Wang Source Type: research
Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3 β/β-catenin signaling in Wistar rats
This study aimed at investigating the effects of chronic treatment with amisulpride (5 mg/kg/day) in the management of 5-fluorouracil (5-FU)-induced cognitive deficits in Wistar rats. Rats received 5 intraperitoneal injections of 5-FU (25 mg/kg every 3 days). 5-FU treatment induced impairments in spatial learning (reduction in object location discrimination ratio) and non-spatial learning (reduction in novel object recognition discrimination ratio). Moreover, 5-FU induced a decrease in the activity of the Wnt/GSK-3β/β-catenin pathway with a decrease in brain-derived neurotrophic factor (BDNF) level in the hippocampus. Th...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Radwa S Raafat Mohamed Z Habib Amany A AbdElfattah Nouran K Olama Sahar M Abdelraouf Nevien Hendawy Khaled A Kamal Salwa A Nawishy Sawsan Aboul-Fotouh Source Type: research
Elevated CRP and TNF- α levels are associated with blunted neural oscillations serving fluid intelligence
DISCUSSION: Elevated inflammatory markers such as CRP and TNF-α were associated with aberrant neural oscillations in regions important for Gf. Linking inflammatory markers with regional neural oscillations may hold promise in identifying mechanisms of cognitive and psychiatric disorders.PMID:37716379 | DOI:10.1016/j.bbi.2023.09.012
Source: Brain, Behavior, and Immunity - September 16, 2023 Category: Neurology Authors: Sarah M Dietz Mikki Schantell Rachel K Spooner Megan E Sandal Amirsalar Mansouri Yasra Arif Hannah J Okelberry Jason A John Ryan Glesinger Pamela E May Elizabeth Heinrichs-Graham Adam J Case Matthew C Zimmerman Tony W Wilson Source Type: research
SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis
CONCLUSIONS: Collectively, our findings identify SRRM4 as a regulator of brain metastasis colonization, and a potential therapeutic target in breast cancer.PMID:37716001 | DOI:10.1093/neuonc/noad175
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Krutika Deshpande Vahan Martirosian Brooke N Nakamura Diganta Das Mukund Iyer Max Reed Ling Shao Daniella Bamshad Noel J Buckley Josh Neman Source Type: research
The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy
CONCLUSION: The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.PMID:37716368 | DOI:10.1002/acm2.14162
Source: Journal of Applied Clinical Medical Physics - September 16, 2023 Category: Physics Authors: Atefeh Rostami Mostafa Robatjazi Seyed Alireza Javadinia Nematullah Shomoossi Ramin Shahraini Source Type: research
Elevated CRP and TNF- α levels are associated with blunted neural oscillations serving fluid intelligence
DISCUSSION: Elevated inflammatory markers such as CRP and TNF-α were associated with aberrant neural oscillations in regions important for Gf. Linking inflammatory markers with regional neural oscillations may hold promise in identifying mechanisms of cognitive and psychiatric disorders.PMID:37716379 | DOI:10.1016/j.bbi.2023.09.012
Source: Brain, Behavior, and Immunity - September 16, 2023 Category: Neurology Authors: Sarah M Dietz Mikki Schantell Rachel K Spooner Megan E Sandal Amirsalar Mansouri Yasra Arif Hannah J Okelberry Jason A John Ryan Glesinger Pamela E May Elizabeth Heinrichs-Graham Adam J Case Matthew C Zimmerman Tony W Wilson Source Type: research
Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
Stereotactic Radiosurgery Results in Non-Small-Cell Lung Cancer Patients with Brain Metastases in the Era of Modern Systemic Treatment Agents
CONCLUSION: Using current systemic agents with radiotherapy for brain metastasis significantly affected post-radiotherapy intracranial progression-free survival.PMID:37712866 | DOI:10.5152/ThoracResPract.2023.23025
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Feyza Ya şar Daşgın Tar ı Kargıoğlu Aliye Arslan Ali Kerim Aksakal Binnur Dadak Fatma Bet ül Ayrak Ezgi G ökçe İpek Pinar Aral Gonca Alt ınışık İnan Y ılmaz Tezcan Source Type: research
Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer's Disease Models
Anal Chem. 2023 Sep 15. doi: 10.1021/acs.analchem.3c02358. Online ahead of print.ABSTRACTBioluminescence imaging has changed the daily practice of preclinical research on cancer and other diseases over the last few decades; however, it has rarely been applied in preclinical research on Alzheimer's disease (AD). In this Article, we demonstrated that bioluminescence imaging could be used to report the levels of amyloid beta (Aβ) species in vivo. We hypothesized that AkaLumine, a newly discovered substrate for luciferase, could bind to Aβ aggregates and plaques. We further speculated that the Aβ aggregates/fibrils/plaques ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Jing Yang Weihua Ding Biyue Zhu Sherri Zhen Shi Kuang Jun Yang Can Zhang Peng Wang Fan Yang Liuyue Yang Wei Yin Rudolph E Tanzi Shiqian Shen Chongzhao Ran Source Type: research
