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Cancer: Brain Cancers
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Total 19412 results found since Jan 2013.
Targeted therapies for glioblastoma treatment
J Physiol Pharmacol. 2023 Jun;74(3). doi: 10.26402/jpp.2023.3.01. Epub 2023 Aug 30.ABSTRACTGlioblastoma, the most common and aggressive type of brain tumor in adults, poses significant challenges in terms of treatment. Conventional approaches including surgery, chemotherapy, and radiotherapy have yielded limited success, with a median survival of approximately 15 months. However, extensive research into the biology of glioblastoma has identified molecular targets that can be exploited by newly developed drugs, leading to the emergence of precise personalized therapies. Several innovative treatment strategies are currently ...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: A Smolarska I Pruszynska W Wasylko K Godlewska M Markowska A Rybak J Botther P Kucharzewska J Nowakowska J Szeliga M Kubiak M Gorczak M Krol Source Type: research
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy
CONCLUSION: 1. Based on our findings, IV delivery coupled with FUS-BBBO is a more efficient means for delivery to deep targets (i.e. striatal-thalamic region) within a predefined spatial conformation compared to IT administration. 2. FUS-BBBO increases the volume of distribution (Vd) of dye after CED administration, but results in a shorter time of residence. Whether this finding is reproducible with other classes of agents (e.g., cytotoxic agents, antibodies, viral particles, cellular therapies) needs to be studied.PMID:37659767 | DOI:10.1016/j.jconrel.2023.08.060
Source: Cancer Control - September 2, 2023 Category: Cancer & Oncology Authors: Rafael Uribe Cardenas Madeline Laramee Nadia Dahmane Mark Souweidane Brice Martin Source Type: research
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
This study aimed to evaluate the safety and activity of two adenoviral vectors expressing HSV1-TK (Ad-hCMV-TK) and Flt3L (Ad-hCMV-Flt3L) in patients with high-grade glioma.METHODS: In this dose-finding, first-in-human trial, treatment-naive adults aged 18-75 years with newly identified high-grade glioma that was evaluated per immunotherapy response assessment in neuro-oncology criteria, and a Karnofsky Performance Status score of 70 or more, underwent maximal safe resection followed by injections of adenoviral vectors expressing HSV1-TK and Flt3L into the tumour bed. The study was conducted at the University of Michigan Me...
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: Yoshie Umemura Daniel Orringer Larry Junck Maria L Varela Molly E J West Syed M Faisal Andrea Comba Jason Heth Oren Sagher Denise Leung Aaron Mammoser Shawn Hervey-Jumper Daniel Zamler Viveka N Yadav Patrick Dunn Wajd Al-Holou Todd Hollon Michelle M Kim D Source Type: research
Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
CONCLUSIONS: While upfront TKI alone proved highly effective in BM control, this study also demonstrated the outcomes of SRS when implemented concurrently with TKI or as salvage therapy for TKI-uncontrolled BMs. This study also presents a strategy of the precise timing and targeting of SRS to lesions in progression.PMID:37656378 | DOI:10.1007/s11060-023-04425-0
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Joseph Shang-En Hung Yan-Hua Su Ching-Jen Chen Chi-Lu Chiang Chia-I Shen Huai-Che Yang Cheng-Ying Shiau Yung-Hung Luo Hsiu-Mei Wu Yong-Sin Hu Chung-Jung Lin Kang-Du Liu Wen-Yuh Chung Wan-Yuo Guo Cheng-Chia Lee Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Stereotactic radiosurgery and anti-PD-1 + CTLA-4 therapy, anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitors, or conventional chemotherapy for the management of melanoma brain metastases
CONCLUSIONS: This is among the largest series evaluating MBM treated with SRS and various systemic therapy regimens. Our analysis noted significant differences in OS, distant MBM control, and sPFS by systemic therapy. No differences in LC or radiation necrosis risk were noted.PMID:37657227 | DOI:10.1016/j.ejca.2023.113287
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Ammoren E Dohm Justyn Y Nakashima Hruday Kalagotla Shirley X Jiang Joseph D Tang Menal Bhandari Youngchul Kim Jasmine A Graham Nikhil I Khushalani Peter A Forsyth Arnold B Etame James K Liu Nam D Tran Michael A Vogelbaum Evan J Wuthrick Hsiang-Hsuan Micha Source Type: research
Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
CONCLUSIONS: While upfront TKI alone proved highly effective in BM control, this study also demonstrated the outcomes of SRS when implemented concurrently with TKI or as salvage therapy for TKI-uncontrolled BMs. This study also presents a strategy of the precise timing and targeting of SRS to lesions in progression.PMID:37656378 | DOI:10.1007/s11060-023-04425-0
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Joseph Shang-En Hung Yan-Hua Su Ching-Jen Chen Chi-Lu Chiang Chia-I Shen Huai-Che Yang Cheng-Ying Shiau Yung-Hung Luo Hsiu-Mei Wu Yong-Sin Hu Chung-Jung Lin Kang-Du Liu Wen-Yuh Chung Wan-Yuo Guo Cheng-Chia Lee Source Type: research
Risk of second primary cancer from proton arc therapy of pediatric brain tumors
This study therefore aimed at evaluating the risk of radiation-induced second primary cancer (SPC) for PAT in pediatric brain tumor patients. Two brain-specific models for SPC induction were applied in five cases to compare volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT) and PAT surrogate plans. The PAT integral dose was reduced by a median of 29% compared to VMAT, and 17% compared to IMPT. For both models, the estimated SPC risks were consistently the lowest for PAT.PMID:37655121 | PMC:PMC10465935 | DOI:10.1016/j.phro.2023.100480
Source: Health Physics - September 1, 2023 Category: Physics Authors: Laura Toussaint Daniel J Indelicato Ludvig P Muren Camilla H Stokkev åg Source Type: research
Multiple functions and dual characteristics of RAB11A in cancers
Biochim Biophys Acta Rev Cancer. 2023 Aug 30:188966. doi: 10.1016/j.bbcan.2023.188966. Online ahead of print.ABSTRACTVesicle trafficking is an unceasing and elaborate cellular process that functions in material transport and information delivery. Recent studies have identified the small GTPase, Ras-related protein in brain 11A (RAB11A), as a key regulator in this process. Aberrant RAB11A expression has been reported in several types of cancers, suggesting the important functions and characteristics of RAB11A in cancer. These discoveries are of great significance because therapeutic strategies based on the physiological and...
Source: Biochimica et Biophysica Acta - September 1, 2023 Category: Biochemistry Authors: Rui-Jian Guo Yu-Fei Cao En-Min Li Li-Yan Xu Source Type: research
Network topology in brain tumor patients with and without structural epilepsy: a prospective MEG study
CONCLUSION: Our data suggest that network topology is altered in brain tumor patients. Histology per se might not, however, tumor-related epilepsy seems to influence the brain's functional network. Longitudinal studies and analysis of possible confounders are required to substantiate these findings.PMID:37655227 | PMC:PMC10467269 | DOI:10.1177/17562864231190298
Source: Adv Data - September 1, 2023 Category: Epidemiology Authors: Barbara Ladisich Stefan Rampp Eugen Trinka Nathan Weisz Christoph Schwartz Theo Kraus Camillo Sherif Franz Marhold Gianpaolo Demarchi Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Sodium fluorescein uptake by the tumor microenvironment in human gliomas and brain metastases
CONCLUSIONS: SF is not just a marker of BBB damage, but its intracellular detection suggests that it selectively accumulates intracellularly. Future efforts should target the mechanisms of its differential uptake by the different TME cell types in depth.PMID:37657099 | DOI:10.3171/2023.7.JNS23873
Source: Journal of Neurosurgery - September 1, 2023 Category: Neurosurgery Authors: Beatrice Musca Camilla Bonaudo Ada Tushe Greta Battaggia Maria G Russo Micol Silic-Benussi Agnese Pedone Alessandro Della Puppa Susanna Mandruzzato Source Type: research
