Filtered By:
Cancer: Brain Cancers
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 19412 results found since Jan 2013.
A Dual-Aware deep learning framework for identification of glioma isocitrate dehydrogenase genotype using magnetic resonance amide proton transfer modalities
CONCLUSION: The proposed deep learning algorithm model constructed based on the image characteristics of the APT modality is effective for glioma IDH genotyping and identification task and may potentially replace the commonly used T1CE modality to avoid contrast agent injection and achieve non- invasive IDH genotyping.PMID:37712275 | PMC:PMC10505564 | DOI:10.12122/j.issn.1673-4254.2023.08.15
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Chu Y Qu T Zhong S Liang Z Wen Y Zhang Source Type: research
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
World Psychiatry. 2023 Oct;22(3):366-387. doi: 10.1002/wps.21110.ABSTRACTPopulations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more com...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Michael Berk Ole K öhler-Forsberg Megan Turner Brenda W J H Penninx Anna Wrobel Joseph Firth Amy Loughman Nicola J Reavley John J McGrath Natalie C Momen Oleguer Plana-Ripoll Adrienne O'Neil Dan Siskind Lana J Williams Andre F Carvalho Lianne Schmaal Ada Source Type: research
Tumoral and peritumoral vascularization of brain tumours: a study comparing an intraoperative ultrasensitive Doppler and a preoperative first-pass perfusion MRI
CONCLUSION: There was a good correlation between a tumor FMBV obtained by a USD intraoperatively and rCCBV on a preoperative MRI validating the reliability of USD for intraoperative analyses of tumor microvascularization in gliomas.PMID:37714376 | DOI:10.1016/j.neuchi.2023.101493
Source: Neuro-Chirurgie - September 15, 2023 Category: Neurosurgery Authors: Camille Courtin Guillaume Lacoin Jean-Pierre Remenieras C écilia Denis Rousselot Paul-Armand Dujardin Ilyess Zemmoura Jean-Philippe Cottier Source Type: research
Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
CONCLUSION: Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.PMID:37710179 | PMC:PMC10503112 | DOI:10.1186/s12575-023-00217-y
Source: Biological Procedures Online - September 14, 2023 Category: Molecular Biology Authors: Min Wu Shihao Wu Yuetong Chen Liangchao Sun Jundong Zhou Source Type: research
Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges and Safe Clinical Trials of Orphan Gene Therapy Products
Curr Gene Ther. 2023 Sep 11. doi: 10.2174/1566523223666230911120922. Online ahead of print.ABSTRACTThe success of gene therapy attempts is controversial and inconclusive. Currently, it is popular among the public, the scientific community, and manufacturers of Gene Therapy Medical Products. In the absence of any remedy or treatment options available for untreatable inborn metabolic orphan or genetic diseases, cancer, or brain diseases, gene therapy treatment by genoceuticals and T-cells for gene editing and recovery remains the preferred choice as the last hope. A new concept of "Genoceutical Gene Therapy" by using orphan ...
Source: Current Gene Therapy - September 13, 2023 Category: Genetics & Stem Cells Authors: Rakesh Sharma Source Type: research
The Prognostic and Functional Impact of Sprouty 2 Expression in Non-small Cell Lung Cancer
CONCLUSION: Spry2 expression was lower in tumor tissues than in normal lung parenchyma. Increased expression of Spry2 is associated with poor prognosis. There were no significant associations between epidermal growth factor receptor, anaplastic lymphoma kinase, or c-ros oncogene 1 rearrangement and Spry2 expression. Despite the absence of KRAS mutational analysis, the clinical and epidemiological features of patients suggested that KRAS mutation might be an underlying determinant factor of the functional role of Spry2 in non-small cell lung cancer.PMID:37700432 | DOI:10.1097/COC.0000000000001044
Source: Clinical Lung Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Yusuf Acikgoz Fatma Unal Yildirim Selin Akturk Esen Gokhan Ucar Yakup Ergun Oznur Bal Mutlu Dogan Dogan Uncu Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges and Safe Clinical Trials of Orphan Gene Therapy Products
Curr Gene Ther. 2023 Sep 11. doi: 10.2174/1566523223666230911120922. Online ahead of print.ABSTRACTThe success of gene therapy attempts is controversial and inconclusive. Currently, it is popular among the public, the scientific community, and manufacturers of Gene Therapy Medical Products. In the absence of any remedy or treatment options available for untreatable inborn metabolic orphan or genetic diseases, cancer, or brain diseases, gene therapy treatment by genoceuticals and T-cells for gene editing and recovery remains the preferred choice as the last hope. A new concept of "Genoceutical Gene Therapy" by using orphan ...
Source: Current Gene Therapy - September 13, 2023 Category: Genetics & Stem Cells Authors: Rakesh Sharma Source Type: research
Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer's disease
Biomed Pharmacother. 2023 Sep 11;167:115450. doi: 10.1016/j.biopha.2023.115450. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) plays a critical role in determining the effectiveness of systemic treatments for brain diseases. Over the years, several innovative approaches in BBB opening and drug delivery have been developed and progressed into clinical testing phases, including focused ultrasound (FUS) with circulating microbubbles, mannitol-facilitated delivery of anti-neoplastic drugs, receptor-mediated transcytosis (RMT) by antibody-drug conjugates (ADCs), and viral vectors for gene therapy. We provided a com...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Gefei Song Pierce Plumlee Ju Young Ahn Stephen Tc Wong Hong Zhao Source Type: research
