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Cancer: Gastric (Stomach) Cancer
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Clinical significance of expression level of ZNF471 in gastric cancer
CONCLUSION: ZNF471 functions as a tumor suppressor during the pathogenesis of GC. Thus, it is a promising biomarker for diagnosis and therapy of GC.PMID:37693683 | PMC:PMC10492033
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Siyuan Li Diyang Chen Huamin Zhang Yong Yang Jianguo Huai Linna Huang Kai Fan Tongyuan Lin Baijing Ding Source Type: research
Effect of indocyanine green near-infrared light imaging technique guided lymph node dissection on short-term clinical efficacy of minimally invasive radical gastric cancer surgery: a meta-analysis
ConclusionThe utilization of indocyanine green near-infrared light imaging technology in the context of minimally invasive radical gastric cancer surgery demonstrates notable efficacy in mitigating the occurrence of postoperative complications surpassing Clavien-Dindo grade II, while concurrently augmenting both the overall quantity of lymph node dissections and the identification of positive lymph nodes, all the while ensuring the preservation of surgical safety. Furthermore, the implementation of this technique proves particularly advantageous in the realm of robotic-assisted radical gastric cancer surgery, thus bearing ...
Source: Frontiers in Oncology - September 11, 2023 Category: Cancer & Oncology Source Type: research
The effect of digital acupressure on chemotherapy-induced nausea in Indonesian patients with stages III-IV breast cancer
In conclusion, acupressure effectively decreased the frequency and severity of nausea in breast cancer patients undergoing neoadjuvant chemotherapy. Acupressure could be implemented as an adjunct intervention in addition to antiemetic therapy for the prevention of CIN in breast cancer patients.PMID:37688948 | DOI:10.1016/j.jaim.2023.100794
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Beni Wicaksono Feriana Ira Hadian Achmad Dafir Firdaus Zulvikar Syambani Ulhaq Source Type: research
Hub genes in adenocarcinoma of the esophagogastric junction based on weighted gene co-expression network analysis and immunohistochemistry
CONCLUSION: Weighted gene co-expression network analysis and immunohistochemistry identified CD93 as a hub gene that might be critical for AEG biology.PMID:37689006 | DOI:10.1016/j.tranon.2023.101781
Source: Translational Oncology - September 9, 2023 Category: Cancer & Oncology Authors: Zhiyong Lai Zhongyuan Bai Shuzhe Yang Rui Zhang Yanfeng Xi Jun Xu Source Type: research
Preoperative conversion therapy achieved pathological complete remission (PCR) in unresectable gastric cancer
Asian J Surg. 2023 Sep 7:S1015-9584(23)01404-5. doi: 10.1016/j.asjsur.2023.09.002. Online ahead of print.NO ABSTRACTPMID:37689521 | DOI:10.1016/j.asjsur.2023.09.002
Source: Asian Journal of Surgery - September 9, 2023 Category: Surgery Authors: Renwang Hu Can Liu Dan Li Source Type: research
A Novel Mutation of < em > MSH2 < /em > Gene in a Patient with Lynch Syndrome Presenting with Thirteen Metachronous Malignancies
J Clin Med. 2023 Aug 24;12(17):5502. doi: 10.3390/jcm12175502.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), accounts for 2-3% of all colorectal cancers. This autosomal dominant disorder is associated with a predisposition to endometrial, stomach, small bowel, pancreatic, biliary tract, ovary, urinary tract, brain, and skin tumors. Lynch syndrome is caused by the mutation of the MLH1, MSH2 (EPCAM), MSH6, and PMS2 genes. In this article, a case study of a 70-year-old female patient with Lynch syndrome is presented. Over a span of 30 years, the patient underwent multiple surgica...
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Ugne Silinskaite Edita Gavelien ė Rokas Stulpinas Ramunas Janavicius Tomas Poskus Source Type: research
Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance
Pathol Res Pract. 2023 Aug 10;250:154761. doi: 10.1016/j.prp.2023.154761. Online ahead of print.ABSTRACTThe high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer ...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Aida Kazemi Masomeh Goodarzi Kosar Daneshipour Hoda Sarabadani Zahra Shahpar Bahareh Salmanian Hajiagha Hadis Kheradjoo Saman Mohammadzadehsaliani Source Type: research
Competing endogenous RNA network characterization of lymph node metastases in Leuran gastric cancer subtypes
In this study, we divided all TCGA gastric cancer patients into the whole, intestinal and diffuse cohorts for further analysis, and constructed competitive endogenous RNA network and evaluated immune cells using CIBERSORTx. The support vector machines recursive feature elimination (SVM-RFE) was used for screening significant signatures and the support vector machines (SVM) for establishing model predicting the lymph node metastasis. The performance of SVM model was good in the intestinal and diffuse cohort, while the model in the whole cohort was relatively poor. Some important co-expression patterns between immune cells a...
Source: Cell Research - September 9, 2023 Category: Cytology Authors: Tianyu Liang Minjun Cheng Ling Lu Renyang Liu Source Type: research
Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance
Pathol Res Pract. 2023 Aug 10;250:154761. doi: 10.1016/j.prp.2023.154761. Online ahead of print.ABSTRACTThe high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer ...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Aida Kazemi Masomeh Goodarzi Kosar Daneshipour Hoda Sarabadani Zahra Shahpar Bahareh Salmanian Hajiagha Hadis Kheradjoo Saman Mohammadzadehsaliani Source Type: research
Long-Term Outcomes of Pylorus-Preserving Gastrectomy for Early Gastric Cancer
DISCUSSION: PPG had advantages with regard to long-term outcomes over DG in terms of weight maintenance and the prevention of rapid gastric emptying. PPG might be efficient in patients with early gastric cancer.PMID:37688476 | DOI:10.1177/00031348231200671
Source: The American Surgeon - September 9, 2023 Category: Surgery Authors: Yurina Saito Tsuyoshi Takahashi Toshirou Nishida Kohei Murakami Shunji Endo Kazuhiro Nishikawa Yutaka Kimura Masaaki Motoori Koji Tanaka Yasuhiro Miyazaki Tomoki Makino Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Hidetoshi Eguchi Yuichiro Doki Source Type: research
Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer
In this study, neural precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) was identified to be conjugated to LSD1 at K63 by ubiquitin-conjugating enzyme E2 M (UBE2M), and this neddylated LSD1 could promote LSD1 ubiquitination and degradation, leading to a decrease of GC cell stemness and chemoresistance. Herein, our findings revealed a novel mechanism of LSD1 neddylation and its contribution to decreasing GC cell stemness and chemoresistance. Taken together, our findings may whistle about the future application of neddylation inhibitors.PMID:37689288 | DOI:10.1016/j.ijbiomac.2023.126801
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Yan-Jia Guo Jing-Ru Pang Yu Zhang Zhong-Rui Li Xiao-Lin Zi Hong-Min Liu Ning Wang Li-Juan Zhao Ya Gao Bo Wang Piet Herdewijn Cheng-Yun Jin Ying Liu Yi-Chao Zheng Source Type: research
Hub genes in adenocarcinoma of the esophagogastric junction based on weighted gene co-expression network analysis and immunohistochemistry
CONCLUSION: Weighted gene co-expression network analysis and immunohistochemistry identified CD93 as a hub gene that might be critical for AEG biology.PMID:37689006 | DOI:10.1016/j.tranon.2023.101781
Source: Translational Oncology - September 9, 2023 Category: Cancer & Oncology Authors: Zhiyong Lai Zhongyuan Bai Shuzhe Yang Rui Zhang Yanfeng Xi Jun Xu Source Type: research
